N,N-Dimethylformamide Dimethyl Acetal N,N-二甲基甲酰胺甲缩醛

CAS 4637-24-5 MFCD00008482

化学结构图

4637-24-5
SMILES: COC(OC)N(C)C

化学属性

Mol. FormulaC5H13NO2
Mol. Weight119.16
Refractive index1.3950 to 1.3980
Boiling Point104.3°C at 760 mmHg
Density0.897 g/mL at 25 °C(lit.)
Flash Point5°C
TSCAYes
Melting Point-85°C
Solubility水解
Danger-Level甲类

别名和识别编码

Chemical NameN,N-Dimethylformamide Dimethyl Acetal
Synonym 1,1-Dimethoxy-N,N-dimethylmethanamine {LY} 1,1-Dimethoxy-N,N-dimethylmethanamine {} {LY} 1,1-Dimethoxy-N,N-dimethylmethanamine {} {} {LY} 1,1-Dimethoxy-N,N-dimethylmethanamine {} {} {} {LY} 1,1-Dimethoxy-N,N-dimethylmethanamine {} {} {} {} {LY} 1,1-Dimethoxy-N,N-dimethylmethanamine {} {} {} {} {} {LY} 1,1-Dimethoxy-N,N-dimethylmethanamine {} {} {} {} {} {} {LY} 1,1-Dimethoxy-N,N-dimethylmethanamine {} {} {} {} {} {} {} {LY} 1,1-Dimethoxy-N,N-dimethylmethanamine {} {} {} {} {} {} {} {} {LY} 1,1-Dimethoxy-N,N-dimethylmethanamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,1-Dimethoxy-N,N-dimethylmethanamine {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} 1,1-Dimethoxy-N,N-dimethylmethanamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,1-Dimethoxy-N,N-dimethylmethanamine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,1-Dimethoxy-N,N-dimethylmethanamine {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {}
CAS Number4637-24-5
PubChem Substance ID78373
EC Number225-063-3
Beilstein Registry Number506020
MDL NumberMFCD00008482
Reaxys-RN506020
Alfabeta NameDIMETHYLFORMAMIDEDIMETHYLACETAL
Chemical Name TranslationN,N-二甲基甲酰胺甲缩醛
InChIKeyZSXGLVDWWRXATF-UHFFFAOYSA-N
LabNetwork Molecule IDLN00184078
InChIInChI=1S/C5H13NO2/c1-6(2)5(7-3)8-4/h5H,1-4H3
Canonical SMILESCN(C)C(OC)OC
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分类

  • {SNA} C-C Bond Formation, Chemical Synthesis, Others, Synthetic Reagents
  • {SNA} Chemical Reagents,
  • {SNA} Acetals/Ketals/Ortho Esters, Alkylation Reagents, Amides, Amines, Analytical Reagents, Analytical/Chromatography, Building Blocks, C-C Bond Formation, Chemical Synthesis, DMF-Dialkylacetals, Derivatization Reagents, Derivatization Reagents GC, GC Derivatization Reagents, by Application, Organic Building Blocks, Others, Oxygen Compounds, Reagents for Alkylation & Esterification, Steroids, Synthetic Reagents
  • {SNA} Acetals/Ketals/Ortho Esters, Alkylation Reagents, Amides,
  • {SNA}

产品应用

  • 酯化作用。喹诺酮类等药物缩合剂

相关文献及参考

  • 1. Tetrahedron 50 , 2255, (1994)
  • 2. Synth. Commun. 24 , 1617, (1994)
  • 3. Aldrichimica Acta 18 , 59, (1985)
  • Synth. Commun. 36 , 3141, (2006)
  • Fieser 3 ,115 / Fieser 4 ,184 / Fieser 5 ,254 / Fieser 6 ,221 / Fieser 8 ,191 / Fieser 9 ,182 / Fieser 11 ,198 / Fieser 13 ,120
  • Aldrich MSDS 1 , 771:A / Corp MSDS 1 (1), 1375:D / FT-IR 1 (1), 328:D / FT-IR 2 (1), 519:A / FT-NMR 1 (1), 528:C / IR-Spectra (3), 193:G / IR-Spectra (2), 174:F / NMR-Reference 2 (1), 285:C / RegBook 1 (1), 357:E / Sigma FT-IR 1 (2), 501:B / Structure Index 1 , 49:A:7 / Vapor Phase 3 , 418:D

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes Xn F,Xn F;Xn
Precautionary statements
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P332+P313
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P301+P312+P330
  • P337+P313
  • P302+P352+P332+P313+P362+P364
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P303+P361+P353
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P370+P378
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P403+P235
  • P305+P351+P338+P337+P313
  • P241+P242+P243
  • P233 Keep container tightly closed. ?保持容器密闭。
Signal word Danger Warning
UN Number UN1993 3271 UN 3271 3/PG 2 1993
Risk Statements
  • R11 Highly flammable 非常易燃
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R20 Harmful by inhalation 吸入有害
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R10 Flammable 易燃
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
  • S33 Take precautionary measures against static discharges 对静电采取预防措施；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Storage condition 2-8°C {LY} 2-8°C Flammables area Moisture Sensitive Store at room temperature {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Packing GroupII
Warnings IRRITANT
Hazard Class3

其他信息

  • F:21
  • Sigma Aldrich:4637-24-5(sigmaaldrich)
  • 水中分解，溶于很多有机溶剂。
  • TCI Shanghai:N,N-二甲基甲酰胺二甲缩醛[用于酯化] N,N-Dimethylformamide Dimethyl Acetal [for Esterification] (0.5ml*10)(4637-24-5)
  • MSDS 信息:N-Dimethoxymethyl-N,N-dimethylamine(4637-24-5).msds
  • Alfa Aesar:N,N-二甲基甲酰胺二甲基乙缩醛,97% N,N-Dimethylformamide dimethyl acetal, 97%(4637-24-5)
  • 存储注意事项:湿度敏感
  • 用途一:有机合成、医药合成中间体，甲脒合成的前体。1，2，3-三酮类和吲哚的制备，喹诺酮类药物缩合剂。可用于合成氧氟沙星，米力农，别嘌呤等药物。
  • 下游产品:1-甲基-5-三氟甲基-1H-吡唑-4-胺 --> 1-叔丁基-5-三氟甲基-1H-吡唑-4-胺 --> 6-吲哚甲酸 --> 2-氨基-4-甲基嘧啶-5-甲酸 --> 1-甲基-5-三氟甲基-1H-吡唑-4-羧酸 --> 3-溴色酮,97% --> 3-硝基-4-吡啶醛 --> 1-甲基-5-三氟甲基-1H-吡唑-4-腈 --> 1-苯基-5-三氟甲基-1H-吡唑-4-腈 --> 1-叔丁基-5-三氟甲基-1H-吡唑-4-腈 --> (1-甲基-5-三氟甲基-1H-吡唑-4-基)甲胺 --> 1-甲基-5-三氟甲基-1H-吡唑-4-酰氯 --> (1-叔丁基-5-三氟甲基-1H-吡唑-4-基)甲胺 --> (1-甲基-5-三氟甲基-1H-吡唑-4-基)甲醇 --> 1-苯基-5-三氟甲基-1H-吡唑-4-酰胺 --> (1-苯基-5-三氟甲基-1H-吡唑-4-基)甲醇 --> 吲哚-7-甲醛 --> (1-叔丁基-5-三氟甲基-1H-吡唑-4-基)甲醇 --> 1-甲基-5-三氟甲基-1H-吡唑-4-酰胺 --> 1-苯基-5-三氟甲基吡唑-4-酰氯 --> 吲哚-6-甲醛 --> (1-苯基-5-三氟甲基-1H-吡唑-4-基)甲胺 --> 3-硝基苯并呋喃-5-醇 --> 1-苯基-5-三氟甲基-1H-吡唑-4-羧酸乙酯 --> 吲哚-6-甲醇 --> 1-叔丁基-5-三氟甲基-1H-吡唑-4-羧酸乙酯 --> 4-(3-吡啶基)-2-氨基嘧啶 --> 4-(氨基甲基)-1-甲基吡唑 --> 1-苯基-5-三氟甲基-1H-吡唑-4-羧酸 --> 5-羟基吲哚 --> 5-甲基-1-苯基-1H-吡唑-4-羧酸 --> 7-羟基吲哚 --> (5-甲基-1-苯基-1H-吡唑-4-基)甲醇 --> 5-甲基-1-苯基-1H-吡唑-4-甲酸乙酯 --> 1-(3-吡啶基)-3-(二甲氨基)-2-丙烯-1-酮
  • MOL 文件:4637-24-5.mol
  • N,N-二甲基甲酰胺二甲基缩醛价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 LA1535001 N,N-二甲基甲酰胺二甲缩醛;1,1-二甲氧基三甲胺; N,N-二甲基二甲氧基甲胺 25g 379元 2011/04/16 D1332 N,N-二甲基甲酰胺二甲缩醛[用于酯化] N,N-Dimethylformamide Dimethyl Acetal [for Esterification] (0.5ml*10) 1SET 790元 2011/04/16 D1293 N,N-二甲基甲酰胺二甲缩醛 N,N-Dimethylformamide Dimethyl Acetal 100ML 1080元
  • 检测方法:GC,NMR
  • 敏感性:Moisture Sensitive
  • 用途二:酯化作用。喹诺酮类等药物缩合剂
  • Acros Organics:N,N-二甲基甲酰胺二甲缩醛 N,N-Dimethylformamide dimethyl acetal, ca 97%(4637-24-5)
  • 海关编码:29225000

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. C-C Bond Formation - Synthetic Reagents
  4. Others - C-C Bond Formation
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. C-C Bond Formation - Synthetic Reagents
  4. Others - C-C Bond Formation
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Amides - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Acetals/Ketals/Ortho Esters - Oxygen Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Derivatization Reagents 衍生分析试剂
  4. Alkylation Reagents - Derivatization Reagents
  5. DMF-Dialkylacetals - Alkylation Reagents
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Derivatization Reagents 衍生分析试剂
  4. Derivatization Reagents GC - Derivatization Reagents
  5. GC Derivatization Reagents, by Application - Derivatization Reagents GC
  6. Amides - GC Derivatization Reagents, by Application
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Derivatization Reagents 衍生分析试剂
  4. Alkylation Reagents - Derivatization Reagents
  5. General Alkylation Reagents - Alkylation Reagents
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. C-C Bond Formation - Synthetic Reagents
  4. Olefination - C-C Bond Formation
  5. Wittig Reagents - Olefination
  1. Analytical & Chromatography 分析化学与色谱
  2. GC Derivatizing Reagents
  1. Analytical & Chromatography 分析化学与色谱
  2. Derivatization Reagents
  3. Alkylation Reagents
  4. Diazoalkales
  1. Analytical & Chromatography 分析化学与色谱
  2. Derivatization Reagents
  3. Derivatization Reagents GC
  4. GC Derivatization Reagents, by Application
  1. Analytical & Chromatography 分析化学与色谱
  2. Derivatization Reagents
  3. Derivatization Reagents GC
  4. Reagents for Acylation
  1. Analytical & Chromatography 分析化学与色谱
  2. Gas Chromatography (GC) 气相色谱
  3. Derivatization Reagents
  4. GC Derivatization Reagents, by Application
  1. Analytical & Chromatography 分析化学与色谱
  2. Gas Chromatography (GC) 气相色谱
  3. Derivatization Reagents
  4. Reagents for Acylation
  1. Analytical & Chromatography 分析化学与色谱
  2. Derivatization Reagents
  3. Derivatization Reagents GC
  4. GC Derivatization Reagents, by Application
  5. Amides
  1. Analytical & Chromatography 分析化学与色谱
  2. Derivatization Reagents
  3. Derivatization Reagents GC
  4. GC Derivatization Reagents, by Application
  5. Biofuels
  1. Analytical & Chromatography 分析化学与色谱
  2. Gas Chromatography (GC) 气相色谱
  3. Derivatization Reagents
  4. GC Derivatization Reagents, by Application
  5. Amides
  1. Analytical & Chromatography 分析化学与色谱
  2. Gas Chromatography (GC) 气相色谱
  3. Derivatization Reagents
  4. GC Derivatization Reagents, by Application
  5. Biofuels
  1. Functional Group 官能团索引
  2. orthocarboxylic acid derivative
  1. Functional Group 官能团索引
  2. amide acetal