(Acetylmethylene)Triphenylphosphorane 1-三苯基膦-2-丙酮

CAS 1439-36-7 MFCD00008774

化学结构图

1439-36-7
SMILES: CC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1

化学属性

Mol. FormulaC21H19OP
Mol. Weight318.35
Melting Point203-205°C
TSCANo
Density1.14
Boiling Point478.5°C at 760 mmHg

别名和识别编码

Chemical Name(Acetylmethylene)Triphenylphosphorane
CAS Number1439-36-7
Synonym 1-(Triphenylphosphoranylidene)propan-2-one {LY} 1-(Triphenylphosphoranylidene)propan-2-one {} {LY} 1-(Triphenylphosphoranylidene)propan-2-one {} {} {LY} 1-(Triphenylphosphoranylidene)propan-2-one {} {} {} {LY} 1-(Triphenylphosphoranylidene)propan-2-one {} {} {} {} {LY} 1-(Triphenylphosphoranylidene)propan-2-one {} {} {} {} {} {LY} 1-(Triphenylphosphoranylidene)propan-2-one {} {} {} {} {} {} {LY} 1-(Triphenylphosphoranylidene)propan-2-one {} {} {} {} {} {} {} {LY} 1-(Triphenylphosphoranylidene)propan-2-one {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} 1-(Triphenylphosphoranylidene)propan-2-one {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-(Triphenylphosphoranylidene)propan-2-one {} {} {} {} {} {} {} {} {} {} {LY} 1-(Triphenylphosphoranylidene)propan-2-one {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-(Triphenylphosphoranylidene)propan-2-one {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-(Triphenylphosphoranylidene)pro
Beilstein Registry Number750077
PubChem Substance ID15038
EC Number215-878-2
MDL NumberMFCD00008774
Reaxys-RN750077
Chemical Name Translation1-三苯基膦-2-丙酮
InChIKeyKAANTNXREIRLCT-UHFFFAOYSA-N
Wiswesser Line Notation1V1UPR&R&R
LabNetwork Molecule IDLN00191697
Canonical SMILESCC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O
InChIInChI=1S/C21H19OP/c1-18(22)17-23(19-11-5-2-6-12-19,20-13-7-3-8-14-20)21-15-9-4-10-16-21/h2-17H,1H3
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分类

  • {SA} C-C Bond Formation, Chemical Synthesis, Olefination, Synthetic Reagents, Wittig Reagents
  • Wittig Reagents
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; ketone; 1fragment
  • {SNA} C-C Bond Formation, Chemical Synthesis, Olefination, Synthetic Reagents, Wittig Reagents

产品应用

  • Wittig Reagent

相关文献及参考

  • Short: III/35E
  • Shearman, G., et al.: J. Mat. Chem., 19, 598 (2009),
  • For C-acylation followed by oxidation of the resulting diacylphosphoranes to give 1,2,3-triketones, see N,O-Bis(trimethyl­silyl)­acetamide, L00183.
  • Beil. 16 ,IV,977
  • Stabilized ylide which converts aldehydes to methyl ɑß-enones (see Appendix 1). Metallation with n-BuLi and alkylation, followed by Wittig reaction with an aldehyde provides a route to ɑß-unsaturated ketones: J. Org. Chem., 38, 4082 (1973); Synth. Commun., 8, 579 (1979):
  • Yang, Z., et al.: Bioorg. Med. Chem., 17, 1071 (2009),

安全信息

RTECSUC3900000
WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 2-8°C {LY} 2-8°C Air Sensitive {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Signal word Warning
GHS Symbol
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 32 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#01327

Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激

其他信息

  • Acros Organics:1-三苯基膦烯-2-丙酮 1-Triphenylphosphoranylidene-2-propanone, 99%(1439-36-7)
  • MOL 文件:1439-36-7.mol
  • 1-三苯基膦-2-丙酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A1439 (乙酰甲烯基)三苯基膦 (Acetylmethylene)triphenylphosphorane 25G 677元 2010/06/21 169971000 1-三苯基膦-2-丙酮 1-Triphenylphosphoranylidene-2-propanone 99% 100 GR 3511元 2010/06/21 169970250 1-三苯基膦-2-丙酮 1-Triphenylphosphoranylidene-2-propanone 99% 25 GR 977元
  • TCI Shanghai:1-三苯基膦-2-丙酮 (Acetylmethylene)triphenylphosphorane,>;98.0%(GC)(1439-36-7)
  • Alfa Aesar:(乙酰亚甲基)三苯基磷烷,99% (Acetylmethylene)triphenylphosphorane, 99%(1439-36-7)
  • Sigma Aldrich:1439-36-7(sigmaaldrich)
  • 敏感性:Air Sensitive
  • 图谱信息:1-三苯基膦-2-丙酮(1439-36-7)红外图谱(IR2) 1-三苯基膦-2-丙酮(1439-36-7)红外图谱(IR1) 1-三苯基膦-2-丙酮(1439-36-7)质谱(MS)

系列性分类


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