Diethyl Pyrocarbonate 焦碳酸二乙酯

CAS 1609-47-8 MFCD00009106

化学结构图

1609-47-8
SMILES: CCOC(=O)OC(=O)OCC

化学属性

Mol. FormulaC6H10O5
Mol. Weight162.14
Refractive indexn20/D 1.398(lit.)
Boiling Point93-94°C at 18 mmHg
Density1.101
Flash Point69°(156°F)
TSCAYes
SolubilitySoluble in chloroform, ethanol (50% w/w), esters, ketones, and hydrocarbons.Slowly soluble in water with hydrolytic decomposition yielding ethanol and CO2.
Stability对湿度敏感
Appearance 无色透明液体, 密度 1.101,沸点 93-94 ℃ , 折射率 1.396-1.4 ,闪点 69 ℃
Melting Point<25 °C

别名和识别编码

Chemical NameDiethyl pyrocarbonate
Synonym Diethyl pyrocarbonate {LY} Diethyl pyrocarbonate Diethylpyrocarbonate Ethoxyformic Anhydride Oxydiformate, Diethyl Pyrocarbonate, Diethyl Pyrocarbonic Acid Diethyl Ester {} {LY} Diethyl pyrocarbonate {} {} {LY} Diethyl pyrocarbonate {} {} {} {LY} Diethyl pyrocarbonate {} {} {} {} {LY} Diethyl pyrocarbonate {} {} {} {} {} {LY} Diethyl pyrocarbonate {} {} {} {} {} {} {LY} Diethyl pyrocarbonate {} {} {} {} {} {} {} {LY} Diethyl pyrocarbonate {} {} {} {} {} {} {} {} {LY} Diethyl pyrocarbonate {} {} {} {} {} {} {} {} {} {LY} Diethyl pyrocarbonate {} {} {} {} {} {} {} {} {} {} {LY} Diethyl pyrocarbonate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Diethyl pyrocarbonate {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Diethyl pyrocarbonate {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Diethyl pyrocarbonate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Diethyl p
CAS Number1609-47-8
PubChem Substance ID3051
EC Number216-542-8
Beilstein Registry Number637031
MDL NumberMFCD00009106
Merck Number14,7998
Chemical Name Translation焦碳酸二乙酯
Wiswesser Line Notation2OVOVO2
LabNetwork Molecule IDLN00193064
InChIInChI=1S/C6H10O5/c1-3-9-5(7)11-6(8)10-4-2/h3-4H2,1-2H3
Canonical SMILESCCOC(OC(OCC)=O)=O
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分类

  • {SNA} Building Blocks, Carbonates, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks
  • {SNA} Biochemicals,
  • {SNA} Alternative Energy,
  • {SNA} Alternative Energy, Building Blocks, Carbonates, Carbonyl Compounds, Chemical Synthesis,
  • {SNA} Biochemicals, Biochemicals and Reagents, Carboxypeptidase P, Core Bioreagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates,
  • {SNA
  • {SNA} Alternative Energy, Building Blocks, Carbonates, Carbonyl Compounds, Chemical Synthesis, Electrolytes, Organic Building Blocks, Organic Solvents, 材料科学
  • {SNA} Biochemicals,

产品应用

  • 蛋白质组氨酸和酪氨酸的修饰试剂。也是RNA酶的化学修饰剂,它和RNA酶的活性基团组氨酸的咪唑环反应而抑制RNA酶活性。

相关文献及参考

  • , Sambrook, J., et al. Molecular Cloning: A Laboratory Manual 2nd ed., Plainview, NY , (1989), 7.3-7.4
  • In the presence of the hindered base lithium dicyclohexylamide (from Dicyclohexyl­amine, A15671), ɑ -ethoxycarbonylation of ketones occurs to give ß -keto esters: Synthesis, 1014 (1984).
  • Merck:14,7998 Beilstein: 3,IV,18
  • Merck:14,7998

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes Xn
RTECSLQ9350000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P312+P330
  • P301+P317
  • P302+P352
  • P304+P312
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Storage condition -20°C {LY} -20°C 2-8°C Moisture Sensitive {} {LY} -20°C {} {} {LY} -20°C {} {} {} {LY} -20°C {} {} {} {} {LY} -20°C {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Packing GroupIII
Hazard Class6.1(b)
UN Number 2810 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1558 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAONAU FAO Nutrition Meetings Report Series.  (Rome, Italy)  No.?-57,
   1948-77.  Discontinued.  Volume(issue)/page/year: 53A,52,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 47 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAONAU FAO Nutrition Meetings Report Series.  (Rome, Italy)  No.?-57,
   1948-77.  Discontinued.  Volume(issue)/page/year: 53A,52,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 850 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAONAU FAO Nutrition Meetings Report Series.  (Rome, Italy)  No.?-57,
   1948-77.  Discontinued.  Volume(issue)/page/year: 51A,67,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAONAU FAO Nutrition Meetings Report Series.  (Rome, Italy)  No.?-57,
   1948-77.  Discontinued.  Volume(issue)/page/year: 53A,52,1974

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 10 ppm/1H
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :

其他信息

  • Diethyl Pyrocarbonate has been shown to inhibit ryanodine binding to ryanodine/Ca2+ receptor channels in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles. This compound could be useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Diethyl Pyrocarbonate also inhibits PAF Acetylhydrolase (platelet-activating factor acetyl hydrolase), and has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
  • 存储注意事项:氮气保护;湿度敏感
  • 有轻微的似果酯香味。难溶于水，遇水分散成CO2及乙醇。与乙醇可混溶。溶于有机溶剂及油脂。
  • Acros Organics:焦碳酸二乙酯 Diethyl pyrocarbonate, pure, 97%(1609-47-8)
  • F:4.4-9-21
  • MSDS 信息:Pyrocarbonic acid diethyl ester(1609-47-8).msds
  • 焦碳酸二乙酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 L1152602 二碳酸二乙酯95％ 25g 790元 2011/08/23 30061486 焦碳酸二乙酯（+4℃） 25ml 865元 2010/06/21 170255000 焦碳酸二乙酯 Diethyl pyrocarbonate 97%, pure 500 GR 10138元
  • 图谱信息:焦碳酸二乙酯(1609-47-8)质谱(MS) 焦碳酸二乙酯(1609-47-8)核磁图( 13 CNMR) 焦碳酸二乙酯(1609-47-8)红外图谱(IR1)
  • 用途一:蛋白质组氨酸和酪氨酸的修饰试剂。也是RNA酶的化学修饰剂,它和RNA酶的活性基团组氨酸的咪唑环反应而抑制RNA酶活性。
  • MOL 文件:1609-47-8.mol
  • 海关编码:29209085
  • 检测方法:NMR
  • 敏感性:Moisture Sensitive
  • Sigma Aldrich:1609-47-8(sigmaaldrich)
  • Alfa Aesar:重碳酸二乙酯,97% Diethyl dicarbonate, 97%(1609-47-8)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carbonates - Carbonyl Compounds
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. R to Z - Enzyme Inhibitors by Enzyme
  7. Ribonuclease A - R to Z
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Amides
  1. Functional Group 官能团索引
  2. carbonic acid monoester
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Dry Powder Media
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Molecular Biology
  4. Gene Expression & Analysis
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Molecular Biology
  4. Molecular Biology Reagents
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Ribonuclease
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Protease Inhibitors
  6. Broad Spectrum Inhibitors of Proteolytic Enzyme Classes
  7. Serine Protease Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Proteolytic Enzymes and Substrates
  5. Protease Inhibitors
  6. Broad Spectrum Inhibitors of Proteolytic Enzyme Classes
  7. Serine Protease Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Signal Transduction Research Tools
  5. Protease Inhibitors
  6. Broad Spectrum Inhibitors of Proteolytic Enzyme Classes
  7. Serine Protease Inhibitors

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