Diethyl maleate 马来酸二乙酯

CAS 141-05-9 MFCD00009191

化学结构图

141-05-9
SMILES: CCOC(=O)C=CC(=O)OCC

化学属性

Mol. FormulaC8H12O4
Mol. Weight172.18
Density1.064
Refractive index1.4390 to 1.4430
Flash Point107°C(lit.)
TSCAYes
Boiling Point225°C at 760 mmHg
Melting Point-10°C
Autoignition Point662 °F
Vapor Density5.93 (vs air)
Vapor Pressure1 mmHg ( 14 °C)
Solubility不溶

别名和识别编码

Chemical NameDiethyl maleate
Synonym Diethyl maleate {LY} Diethyl maleate {} {LY} Diethyl maleate {} {} {LY} Diethyl maleate {} {} {} {LY} Diethyl maleate {} {} {} {} {LY} Diethyl maleate {} {} {} {} {} {LY} Diethyl maleate {} {} {} {} {} {} {LY} Diethyl maleate {} {} {} {} {} {} {} {LY} Diethyl maleate {} {} {} {} {} {} {} {} {LY} Diethyl maleate {} {} {} {} {} {} {} {} {} {LY} Diethyl maleate {} {} {} {} {} {} {} {} {} {} {LY} Diethyl maleate {} {} {} {} {} {} {} {} {} {} {} {LY} Diethyl maleate {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Diethyl maleate {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Diethyl maleate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Diethyl maleate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Diethyl maleate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Diethyl maleate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Diethyl maleate {} {} {} {} {} {} {} {} {} {
CAS Number141-05-9
EC Number205-451-9
Beilstein Registry Number1100825
MDL NumberMFCD00009191
Merck Number3123
PubChem Substance ID87572130
Reaxys-RN907616
Chemical Name Translation马来酸二乙酯
Wiswesser Line Notation2OV1U1VO2
LabNetwork Molecule IDLN00237957
InChIInChI=1S/C8H12O4/c1-3-11-7(9)5-6-8(10)12-4-2/h5-6H,3-4H2,1-2H3/b6-5-
Canonical SMILESO=C(OCC)/C=C\C(OCC)=O
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分类

  • {uni_hamburg} no charge; ester; 1fragment
  • {SNA} Alphabetical Listings, C-D, Flavors and Fragrances
  • {SNA} Building Blocks, C8 to C9, Carbonyl Compounds, Chemical Synthesis, Esters, Organic Building Blocks
  • {SNA} Alphabetical Listings, C-D, Certified Food Grade Products, Flavors and Fragrances
  • {Chemicalbook} 农药中间体: 杀虫剂中间体: 有机磷类杀虫剂

产品应用

  • 检定氨和钾。气相色谱固定液(最高使用温度40℃,溶剂为苯、氯仿、乙醇)。用于树脂和硝化纤维素的溶剂,增塑剂,有机合成,杀虫剂,高聚物单体,塑料助剂。

相关文献及参考

  • Short: III/47
  • Merck: 14,3123 Beilstein:2,751
  • Short: II/5
  • Merck: 14,3123
  • Short: III/38B

安全信息

Signal word Warning
GHS Symbol
WGK Germany2
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Risk Statements
  • R36 Irritating to eyes 刺激眼睛
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R52/53
Precautionary statements
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
RTECSON1225000
Hazard statements
  • H303+H313
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes Xi
Storage condition 2-8°C {LY} 2-8°C Store at room temperature {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°
UN Number 3334
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 14,443,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 4 mL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 10/29/1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 31,60,1949

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3070 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Gastrointestinal - changes in structure or function of salivary glands
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   52,422,1980

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 225 umol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,193,1988

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 8700 nmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 182,135,1987

其他信息

  • Alfa Aesar:顺丁烯二酸二乙酯,97% Diethyl maleate, 97%(141-05-9)
  • 用途四:检定氨和钾。气相色谱固定液(最高使用温度40℃,溶剂为苯、氯仿、乙醇)。用于树脂和硝化纤维素的溶剂,增塑剂,有机合成,杀虫剂,高聚物单体,塑料助剂。
  • 用途二:顺丁烯二酸二乙酯又名马来酸二乙酯,在农药上用于制备有机磷杀虫剂马拉硫磷,另外也是医药、香料、水质稳定剂(有机多元羧酸膦
  • 图谱信息:马来酸二乙酯(141-05-9)核磁图( 1 HNMR) 马来酸二乙酯(141-05-9)质谱(MS) 马来酸二乙酯(141-05-9)Raman光谱 马来酸二乙酯(141-05-9)核磁图( 13 CNMR) 马来酸二乙酯(141-05-9)红外图谱(IR1)
  • Acros Organics:马来酸二乙酯 Diethyl maleate, remainder ca.10% diethyl fumarate, ca.90%(141-05-9)
  • 方法二:由顺丁烯二酸酐和乙醇在硫酸存在下酯化制得;也可用阳离子交换树脂为催化剂进行交换转化而得。工业品顺丁烯二酸二乙酯含量≥98%,
  • 方法二:由顺丁烯二酸酐和乙醇在硫酸存在下酯化制得;也可用阳离子交换树脂为催化剂进行交换转化而得。工业品
  • 下游产品:马拉硫磷 --> 5-甲氧基甲基-2,3-吡啶二羧酸 --> 9-芴乙酸 --> 3-(2-氯苯基)丙酸 --> 2,3-二氯丁二酸二乙酯
  • 用途一:用作农药中间体,用于制备有机磷农药马拉硫磷,也可用于生产香料
  • 马来酸二乙酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0010 马来酸二乙酯 Diethyl Maleate 25ML 136元 2014/06/02 M0010 马来酸二乙酯 Diethyl Maleate 500ML 380元 2010/06/21 114440050 马来酸二乙酯 Diethyl maleate ca.90%, remainder ca.10% diethyl fumarate 5 GR 268元
  • 蒸气密度:5.93 (vs air)
  • {Che
  • 方法一:其制备方法主要由顺丁烯二酸酐和乙醇在硫酸存在下酯化制得。 此工艺有常压有苯酯化和负压无苯酯化两种。 (1)常压有苯酯化 将一定量的苯和乙醇加入酯化反应锅,投入顺丁烯二酸酐,在搅拌下滴加浓硫酸,通夹套蒸汽加热,使反应物在75℃左右进行酯化反应。生成的水与苯、乙醇通过三元共沸蒸馏除去,上层的苯、乙醇液回流人反应锅中。约13~14h后,当蒸馏塔顶温度升至68.2℃,分离器下层水液位不再上升时,表明反应锅内水分已经全部蒸出,酯化反应完成。停止回流,继续蒸馏至95~100℃,蒸出苯和乙醇。冷却降温至50℃左右,用5%碳酸钠水溶液进行中和处理,水洗后再真空脱除残余的苯及乙醇,即得到产品顺丁烯二酸二乙酯。 (2)负压无苯酯化 顺丁烯二酸酐和乙醇在硫酸作用下酯化,在一定的真空和温度下将乙醇和反应生成的水呈气态带出,然后通过分馏塔分离出乙醇回流酯化,使反应趋向完全。这种方法能缩短反应周期,提高收率和产品质量,改善操作环境,国内生产厂大都采用此法。 此外,还可用阳离子交换树脂为催化剂进行交换转化,制得顺丁烯二酸二乙酯。
  • 方法二:由顺丁烯二酸酐和乙醇在硫酸存在下酯化制得;也可用阳离子交换树脂为催化剂进行交换转化而得。工业品顺丁烯二酸二乙酯含量≥98%,每
  • MOL 文件:141-05-9.mol
  • MSDS 信息:马来酸二乙酯(141-05-9).msds
  • 方法二:由顺丁烯二酸酐和乙醇在硫酸存在下酯化制得;也可用阳离子交换树脂为催化剂进行交换转化而得。工业品顺丁烯二酸二乙酯含量≥98%,每吨产品消耗顺丁烯二
  • Sigma Aldrich:141-05-9(sigmaaldrich)
  • 在碱性溶液中极易水解。易溶于乙醇、乙醚、烷烃等有机溶剂,微溶于水
  • 上游原料:
  • 上游原料:马来酸酐 --> 苯乙醇 --> 阳离子交换树脂 --> 乙醇95% --> 苯酯

系列性分类


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