Halothane 1-溴-1-氯-2,2,2-三氟乙烷
CAS 151-67-7 MFCD00009602
化学结构图
SMILES: FC(F)(F)C(Cl)Br
化学属性
| Mol. Formula | C2HBrClF3 |
|---|---|
| Mol. Weight | 197.39 |
| Refractive index | 1.3691 |
| Boiling Point | 49-50° |
| Vapor Pressure | 4.5 psi ( 20 °C) |
| Density | 1.872 |
| TSCA | No |
| Flash Point | 49-50°C |
| Appearance | 无色透明易流动挥发性液体。沸点50.2℃，相对密度1.86（20/4℃），折光率1.3691。可与有机溶剂互溶，微溶于水。有不愉快的芳香气，味甜，有灼感。性质稳定，不燃烧爆炸。 |
别名和识别编码
| Chemical Name | 1-Bromo-1-Chloro-2,2,2-Trifluoroethane |
|---|---|
| Synonym | (±)-Halothane 1,1,1-Trifluoro-2-Chloro-2-Bromoethane 1,1,1-Trifluoro-2-bromo-2-chloroethane 1,1,1-Trifluoro-2-chloro-2-bromoethane 1,1,1-trifluoro-2-chloro-2-bromoethane 1,1,1-三氟-2-氯-2-溴乙烷 1-BROMO-1-CHLORO-2,2,2-TRIFLUOROETHANE 1-Bromo-1-chloro-2,2,2-trifluoroethane 1-bromo-1-chloro-2,2,2-trifluoro-ethan 1-bromo-1-chloro-2,2,2-trifluoroethane 2,2,2-Trifluoro-1-chloro-1-bromoethane 2,2,2-trifluoro-1-bromo-1-chloroethane 2-BROMO-2-CHLORO-1,1,1-TRIFLUOROETHANE 2-Brom-2-chlor-1,1,1-trifluorethan 2-Bromo-2-chloro-1,1,1-trifluoroethane 2-Chloro-2-bromo-1,1,1-trifluoroethane 2-bromo-2-chloro-1,1,1-trifluoro-ethan 2-bromo-2-chloro-1,1,1-trifluoro-ethane 2-bromo-2-chloro-1,1,1-trifluoroethane Alotano {PubCh |
| MDL Number | MFCD00009602 |
| CAS Number | 151-67-7 |
| PubChem Substance ID | 3562 |
| EC Number | 205-796-5 |
| Beilstein Registry Number | 1736947 |
| Merck Number | 14,4603 |
| Chemical Name Translation | 1-溴-1-氯-2,2,2-三氟乙烷 |
| Wiswesser Line Notation | GYEXFFF |
| LabNetwork Molecule ID | LN00194921 |
| InChI | InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H |
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分类
- {uni_hamburg} no charge; racemate; 1fragment
- {SNA} B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Core Bioreagents, Enzyme Inhibitors, Neurobiology, Neuroscience, Pharmacologicals, Research Essentials, Sedative/Hypnotics
相关文献及参考
- Short: III/38B Title: Refractive Indices of Organic Liquids Author: Wohlfarth, Ch.; Wohlfarth, B. Editor: Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/38B Year: 1996 Keyword: organic compounds; refractive index; liquids ISBN: 3-540-60596-7 ISBN: 978-3-540-60596-6 Internet Resource: DOI:10.1007/b85533 RefComment: VII, 4210 pages, Hardcover Abstract: Volume III/38 Optical Constants provides critically evaluated data on refractive indices of inorganic and organic liquids and their wavelength dependence (dispension). Part A contains the inorganic, organometallic, and organononmetallic liquids, and the binary liquid mixtures (about 900 pure substances and their mixtures). Part B contains data of more than 7600 organic liquids.
- Short: IV/10A Title: Heats of Mixing and Solution: Binary Liquid Systems of Nonelectrolytes Author: Grolier, J.-P.E.; Wormald, C.J.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H.V. Editor: Kehiaian; H.V. Source: Landolt-Börnstein, New Series Volume: IV/10A Year: 2004 Keyword: Nitrogen Containing; Organic Compounds; Pressure; Vapor; Vapor Pressure ISBN: 3-540-60347-6 ISBN: 978-3-540-60347-4 Internet Resource: DOI: 10.1007/b56530 RefComment: IX, 564 p. 816 illus., Hardcover RefComment: Written for scientists and engineers in the field of physical chemistry, organic chemistry, applied chemistry Abstract: This subvolume containes selected data on heats of mixing (excess enthalpies) of binary liquid mixtures of organic and inorganic nonelectrolytes, including aqueous-organic systems, in broad ranges of temperature, pressure, and composition. All the data are extracted from the original literature published from 1957 to 2003. The printed volume presents tables for 800 representative mixtures. The CD-ROM displays all these data, as well as 2853 additional data files, in PDF format and in a fully documented computer readable standard electronic file (SELF) format. Moreover, the ELBT-program allows
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H318 Causes serious eye damage 严重伤害眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P203
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P264+P265
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P302+P352
- P304+P340
- P305+P351+P338
- P305+P354+P338
- P307+P311
- P308+P313
- P308+P316
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P317
- P318
- P319
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P332+P317
- P337+P313
- P337+P317
- P362+P364
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
- R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
- R20 Harmful by inhalation 吸入有害
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 6 gm/kg TOXIC EFFECTS : Behavioral - excitement Behavioral - antipsychotic REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 24(3),36,1980
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 98 gm/m3/2H TOXIC EFFECTS : Brain and Coverings - other degenerative changes Liver - other changes Kidney, Ureter, Bladder - other changes REFERENCE : TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued. Volume(issue)/page/year: 111,10,1975
TYPE OF TEST
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5680 mg/kg TOXIC EFFECTS : Behavioral - excitement Behavioral - antipsychotic REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupati
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5680 mg/kg TOXIC EFFECTS : Behavioral - excitement Behavioral - antipsychotic REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 24(3),36,1980
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - hamster Fibroblast DOSE/DURATION : 1 pph REFERENCE : ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 43,21,1975
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - mouse Fibroblast DOSE/DURATION : 1000 ppm REFERENCE : ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 12,366,1976
TYPE OF TEST : Unscheduled DNA synthesis ROUTE OF EXPOSURE : Inhalation TEST SYSTEM : Rodent - rat DOSE/DURATION : 1000 ppm/2H (Continuous) REFERENCE : ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 30,401,1969
TYPE OF TEST : DNA inhibition ROUTE OF EXPOSURE
TYPE OF TEST : Cytogenetic analysis
TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Inhalation TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 1 pph/1H REFERENCE : ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 62,305,1985
TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 3450 ppm/24H (Continuous) REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 91,225,1981
{hazaTYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 100 ppm/8H
SEX/DURATION : female 2-22 day(s) after conception
lactating female 30 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
BBREDI Behavioural Brain Research. (Elsevier Science Publishers B.V., POB
211, 1000 AE Amsterdam, Netherlands) V.1- 1980- Volume(issue)/page/year:
36,147,1990TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE
TYPE OF TEST
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE : 3000 ppm/4H
SEX/DURATION : female 9 week(s) pre-mating
female 1-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350
Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year:
51,532,1979TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE : 8000 ppm/12H SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 29,1167,1968
{haz其他信息
- 图谱信息:氟烷(151-67-7)红外图谱(IR1) 氟烷(151-67-7)核磁图( 1 HNMR) 氟烷(151-67-7)核磁图( 13 CNMR) 氟烷(151-67-7)Raman光谱 氟烷(151-67-7)质谱(MS)
- MOL 文件:151-67-7.mol
- Sigma Aldrich:151-67-7(sigmaaldrich)
- 方法一:由三氟三氯乙烷经消除、加成、重排、还原等步骤制得。
- F:8-19
- Alfa Aesar:1-溴-1-氯-2,2,2-三氟乙烷,99% 1-Bromo-1-chloro-2,2,2-trifluoroethane, 99%(151-67-7)
- 上游原料:1,1,2-三氟三氯乙烷
- Hazard Note:Irritant
- 蒸气压:4.5 psi ( 20 °C)
- 用途一:该品为常用的新型全身吸入麻醉药。麻醉作用较乙醚强而迅速，诱导期很短，但镇痛和肌肉松驰作用不强，用量少，无刺激性。可用于小手术或复合麻醉。该品的缺点是抑制心脏和扩张血管，能使血压下降，脑血管扩张导致颅内压升高和对呼吸中枢有抑制作用。
- 下游产品:塑料光纤 --> 1,1-二氟乙烯(偏氟乙烯)
- 氟烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/05/25 L10179 1-溴-1-氯-2,2,2-三氟乙烷, 99% 1-Bromo-1-chloro-2,2,2-trifluoroethane, 99% 25g 385元 2010/05/25 L10179 1-溴-1-氯-2,2,2-三氟乙烷, 99% 1-Bromo-1-chloro-2,2,2-trifluoroethane, 99% 100g 1050元
- 敏感性:Light Sensitive
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