• 原料直供
• 试剂商城
• 直接询价

分类

• {uni_hamburg}
• {SNA} Bioactive Small Molecules, Carbodiimides, Chemical Synthesis, Coupling, D-DIF, Synthetic Reagents, 细胞生物学
• {SNA} Bioactive Small Molecules, Carbodiimides, Chemical Biology, Chemical Synthesis, Coupling,
• {SNA} Carbodiimides, Chemical Synthesis, Coupling,
• {SNA} ChemDose, Chemical Synthesis, Specialty Synthesis
• {SNA} Carbodiimides, Chemical Synthesis, Coupling, Synthetic Reagents
• {SNA} Bioactive Small Molecules, Carbodiimides, Cell Biology, Chemical Biology, Chemical Synthesis, Coupling, D-DIF,

产品应用

• 脱氢偶联试剂，修饰小牛心线粒体脱氢转移酶；抑制F1F0-ATPase和其它的质子转移酶。 多肽合成试剂。

相关文献及参考

• In peptide coupling reactions, various auxiliary reagents have been used to suppress racemization. See, e.g., N-Hydroxysuccinimide, A10312, N-Hydroxyphthalimide, A13862, and endo-N-Hydroxy-5-
• In the pre
• For ester or thioester formation from an acid and an alcohol, the rate is greatly increased by addition of 4-(Dimethyl­amino)­pyridine, A13016: Angew. Chem. Int. Ed., 17, 522 (1978). For t-butyl esters, see: Org. Prep. Proced. Int., 20, 180 (1988); Org. Synth. Coll., 7, 93 (1990). The same combination has been found useful in macrolactonization reactions: J. Org. Chem., 50, 2394 (1985); and in formation of propynoic esters under mild conditions: Tetrahedron Lett., 30, 4575 (1989).
• In the presence of H2SO4 or AlCl3, Friedel-Crafts cyclohexylation of arenes has been reported
• Promotes a variety of acylation reactions between carboxylic acids and nucleophiles; the dicyclohexylurea by-product is almost insoluble in most solvents:
• DCC has also been used in dehydrations, e.g. carboxylic acids to anhydrides: J. Am. Chem. Soc., 85, 1997 (1963); J. Org. Chem., 54, 1922 (1989); primary amides: J. Org. Chem., 26, 3356 (1961), and aldoximes: Synth. C
• DCC has also been used in dehydrations, e.g. carboxylic acids to anhydrides: J. Am. Chem. Soc., 85, 1997 (1963); J. Org. Chem., 54, 1922 (1989); primary amides: J. Org. Chem., 26, 3356 (1961), and aldoximes: Synth. Commun., 3, 101 (1973); 12, 25 (1982) to nitriles; dialkylacetic acids to ketenes (where stable): Synthesis, 568 (1989). The combination with Dimethyl­ sulfoxide, A13280, is used in the Pfitzner-Moffatt oxidation of alcohols to carbonyl compounds under mild conditions: J. Am. Chem. Soc., 85, 3027 (1963); 87, 5661, 5670 (1965); Org. Synth. Coll., 5, 242 (1973); review: Synthesis, 857 (1990).
• Neises, B. et al.: Org. Synth., 7, 93 (1990); Liang, G.-B. et al.: Tetrahed. Lett., 37, 6627 (1996);
• Merck:14,3096
• Merck:1

安全信息

GHS Symbol

其他信息

• 图谱信息:二环己基碳二亚胺(538-75-0)Raman光谱 二环己基碳二亚胺(538-75-0)核磁图( 13 CNMR) 二环己基碳二亚胺(538-75-0)红外图谱(IR1) 二环己基碳二亚胺(538-75-0)红外图谱(IR2) 二环己基碳二亚胺(538-75-0)红外图谱(IR3)
• Acros Organics:二环己基碳二亚胺/DCC N,N'-Dicyclohexylcarbodiimide, 0.1M sol.in DCM, peptide synthesis grade(538-75-0)
• {
• 上游原料:吡啶 --> 尿素 --> 二硫化碳 --> 环己胺 --> 十二氢二苯胺 --> N,N-二环己脲 --> 二环己基硫脲 --> N,N'-二环己基硫脲
• 用途四:脱氢偶联试剂，修饰小牛心线粒体脱氢转移酶；抑制F
• 溶于苯、乙醇、乙醚等大多数有机溶剂
• 用途二:用作生化试剂和有机合成脱水缩合剂
• 存储注意事项:湿度敏感
• 下游产品:S-3-氨基奎宁环胺盐酸盐 --> 依那普利 --> 2-氰基吡啶-4-醛 --> Β-丙氨酸叔丁酯盐酸盐 --> 萘酚AS-BI磷酸盐 --> 甲巯丙脯酸 --> 3-(2- 甲氧基 -5- 甲基苯基 )-3- 苯基丙酸 --> 1-(2-异氰基乙基)-4-甲基哌嗪 --> 叔丁基甲基马来酸酯 --> 异丁酸酐 --> 赖诺普利 --> 2-吗啉异烟酰醛 --> (6R,7R)-7-[[(2-氨基-4-噻唑基)-[(1-羧基-1-甲基乙氧基)亚氨基]乙酰基]氨基]-2-羧基-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-3-甲基吡啶鎓内盐 --> 7-二乙基氨基-3-噻吩甲酰基香豆素 --> 头孢丙烯 --> 4-异氰基苯酮 --> 多西他赛 --> 腺苷环磷酸酯 --> 血管紧张素II --> 头孢地嗪 --> 贝前列素 --> 醋酸奥曲肽 --> 群多普利 --> 焦磷酸四苄酯 --> 帕罗西汀 --> 盐酸贝奈克酯 --> 伊布利特 --> 拉坦前列腺素
• 用途三:用于阿米卡星及氨基酸的合成脱水，是一种很好的低温生化脱水剂，也用于酸、酐、醛、酮等的合成。在日本，用于谷胱甘肽的脱水剂，占总消费的90%。该品作为脱水缩合剂时，可在常温下经短时间反应即成，反应后产物为二环己基脲。由于该产物在有机溶剂中溶解度很小，所以反应产物易于分离；同时，由于该品很难溶于水，因此即使是在水溶液中，反应仍然可以进行下去。该品还用于肽、核酸的合成，使用本品可以在室温下很容易由具有游离羧基的化合物和具有游离氨基的化合物合成肽，并且收率很高。用于生产增血压素、环磷酸腺苷。
• Alfa Aesar:N,N'-二环己基碳二亚胺,99% N,N'-Dicyclohexylcarbodiimide, 99%(538-75-0)
• TCI Shanghai:N,N'-二环己基碳二亚胺[用于肽合成] N,N'-Dicyclohexylcarbodiimide [for Peptide Synthesis],>;98.0%(GC)(538-75-0)
• Sigma Aldrich:538-75-0(sigmaaldrich)
• 二环己基碳二亚胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw020080 N,N’-二环己基碳二亚胺 100g 135元 2011/08/23 30056326 N，N-二环己基碳酰亚胺 100g 65元 2011/08/23 30056328 N，N-二环己基碳酰亚胺 500g 260元
• 检测方法:GC,NMR
• 方法一:1.二环己基硫脲法工业上由环己胺与二硫化碳反应生成N,N'-二环己基硫脲，经脱硫化氢而得。2.二环己胺尿素法也可由N,N'-二环己基脲与五氧化二磷在吡啶中反应而得。
• 敏感性:Moisture Sensitive
• 用途一:主要用于阿米卡星及氨基酸的合成脱水，是一种很好的低温生化脱水剂
• 溶于苯、乙醇、乙醚等大多数有机溶剂，不溶于水，和水反应。对潮湿敏感，皮肤接触可引起过敏。二氯甲烷溶解度：1G / 10ML。