Domiphen bromide 度米芬

CAS 538-71-6 MFCD00011769

化学结构图

538-71-6
SMILES: CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1.[Br-]

化学属性

Mol. FormulaC22H40BrNO
Mol. Weight414.46
Melting Point117-119°C
TSCAYes
Appearance 白色或微黄色片状结晶;无臭或微带特臭,味苦;振摇水溶液,则发生泡沫。本品在乙醇或氯仿中极易溶解,在水中易溶,在丙酮中略溶,在乙醚中几乎不溶。
Density0.863
Stability易吸潮

别名和识别编码

Chemical NameDomiphen bromide
MDL NumberMFCD00011769
CAS Number538-71-6
Synonym Domiphen (bromide) {Chemicalbook} (DODECYLDIMETHYL-2-PHENOXYETHYL)-AMMONIUM BROMIDE (Dodecyldimethyl-2-phenoxyethyl)ammonium bromide 1-Dodecanaminium, N,N-dimethyl-N-(2-phenoxyethyl)-, bromide Ammonium bromide, dodecyldimethyl(2-phenoxyethyl)- Ammonium, dodecyldimethyl(2-phenoxyethyl)-, bromide Bradasol Bradonit Bradoral Bradosol Bradosol bromide DOMIPHEN DOMIPHEN BROMIDE DOMOPHEN BROMIDE Dodecyldimethyl(2-phenoxyethyl)ammonium bromide Domiphen Domiphen bromide Fungitex Fungitex R LABOTEST-BB LT00847867 NSC-39415 Oradol PDDB Phenododecinium bromide beta-Phenoxyethyldimethyldodecylammonium bromide beta-phenoxyethyldimethyldodecylammoniumbromide
EC Number208-702-0
Merck Number14,3415
Beilstein Registry Number3922742
PubChem Substance ID10866
Chemical Name Translation度米芬
Wiswesser Line Notation12K2OR &E &3/9
LabNetwork Molecule IDLN00224234
InChIInChI=1S/C22H40NO.BrH/c1-4-5-6-7-8-9-10-11-12-16-19-23(2,3)20-21-24-22-17-14-13-15-18-22;/h13-15,17-18H,4-12,16,19-21H2,1-3H3;1H/q+1;/p-1
Canonical SMILESCCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1.[Br-]
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分类

  • {SNA} Ammonium Salts, Chemical Synthesis, Phase Transfer Catalysts, Synthetic Reagents

产品应用

  • 可用于口腔、咽喉感染的辅助治疗及皮肤、创伤感染。

相关文献及参考

  • Merck:14,3415

安全信息

RTECSBQ2030000
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Storage condition 2-8°C, sealed storage, away from moisture {ALF} Hygroscopic RT
WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
UN Number UN 2811 6.1/PG 3 2811
Packing GroupIII
Hazard Class6.1
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 31 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 6,307,1947

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co.,
   1956-59  Volume(issue)/page/year: 1,222,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 6,307,1947

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 11 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,351,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Details

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

其他信息

  • Alfa Aesar:溴化十二烷基-二甲基-2-苯氧基-乙基胺,97% Domiphen bromide, 97%(538-71-6)
  • MSDS 信息:(Dodecyldimethyl-2-phenoxyethyl)ammonium bromide(538-71-6).msds
  • 度米芬价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/05/25 L12930 溴化十二烷基-二甲基-2-苯氧基-乙基胺, 97% Domiphen bromide, 97% 25g 332元 2010/05/25 L12930 溴化十二烷基-二甲基-2-苯氧基-乙基胺, 97% Domiphen bromide, 97% 100g 949元
  • MOL 文件:538-71-6.mol
  • 用途一:可用于口腔、咽喉感染的辅助治疗及皮肤、创伤感染。
  • 无臭或微带特臭,味微苦而带皂味,极易溶于乙醇和氯仿,溶于水,在乙醚中几乎不溶。以溴代十二烷与苯氧乙基二甲胺为原料制得。常用溴化度米芬。为阳离子表面活性广谱杀菌剂,其作用在碱性中增强。
  • 图谱信息:度米芬(538-71-6)红外图谱(IR2) 度米芬(538-71-6)核磁图( 1 HNMR) 度米芬(538-71-6)红外图谱(IR1) 度米芬(538-71-6)核磁图( 13 CNMR)
  • 敏感性:Hygroscopic
  • Sigma Aldrich:538-71-6(sigmaaldrich)

系列性分类


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