(Methoxymethyl)triphenylphosphonium chloride 甲氧基甲基三苯基氯化磷

CAS 4009-98-7 MFCD00011800

化学结构图

4009-98-7
SMILES: COC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Cl-]

化学属性

Mol. FormulaC20H20ClOP
Mol. Weight342.80
Melting Point185-195°C
TSCANo
Density1.422
Solubility分解
Flash Point>250°C
Appearance 白色至类白色晶体，熔点195-197℃，闪点 >;250°C，

别名和识别编码

Chemical Name(Methoxymethyl)triphenylphosphonium Chloride
Beilstein Registry Number3599844
PubChem Substance ID2723798
CAS Number4009-98-7
EC Number223-664-5
MDL NumberMFCD00011800
Reaxys-RN3599844
Synonym (Methoxymethyl)triphenylphosphonium chloride {LY} (Methoxymethyl)triphenylphosphonium chloride {} {LY} (Methoxymethyl)triphenylphosphonium chloride {} {} {LY} (Methoxymethyl)triphenylphosphonium chloride {} {} {} {LY} (Methoxymethyl)triphenylphosphonium chloride {} {} {} {} {} {} {} {} {LY} (Methoxymethyl)triphenylphosphonium chloride {} {} {} {} {} {LY} (Methoxymethyl)triphenylphosphonium chloride {} {} {} {} {} {} {LY} (Methoxymethyl)triphenylphosphonium chloride {} {} {} {} {} {} {} {LY} (Methoxymethyl)triphenylphosphonium chloride {} {} {} {} {} {} {} {} {LY} (Methoxymethyl)triphenylphosphonium chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} (Methoxymethyl)triphenylphosphonium chloride {} {} {} {} {} {} {} {} {} {} {LY} (Methoxymethyl)triphenylphosphonium chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} (Methoxymethyl)triphenylphosphonium chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Chemical Name Translation甲氧基甲基三苯基氯化磷
InChIKeyKEEARDDBDSZNOY-UHFFFAOYSA-N
LabNetwork Molecule IDLN00188377
InChIInChI=1S/C20H20OP.ClH/c1-21-17-22(18-11-5-2-6-12-18,19-13-7-3-8-14-19)20-15-9-4-10-16-20;/h2-16H,17H2,1H3;1H/q+1;/p-1
Canonical SMILESCOC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3.[Cl-]
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分类

  • {SNA} C-C Bond Formation, Chemical Synthesis, Olefination, Synthetic Reagents, Wittig Reagents

产品应用

  • Wittig-试剂的前提物质,用于羰基化合物的甲氧基亚甲基化; 如用在合成类固醇、倍半萜化合物、前列腺索类似物。(Methoxymethyl)triphenylphosphonium chloride

相关文献及参考

  • Beilstein: 16,IV,987
  • Wittig reaction (see Appendix 1) of the derived phosphorane with aldehydes and ketones gives enol ethers, readily hydrolyzed to homologous aldehydes. For an example (adamantanone to adamantanecarboxaldehyde), see: Chem. Ber., 95, 2514 (1962). For use of the reaction in the synthesis of hydroisoquinoline AMPA antagonists, see: J. Med. Chem., 39, 2219 (1996). Reaction with chiral 2,3-epoxyaldehydes provides an enantioselective synthesis of (E)-4-hydroxyalkenes: J. Chem. Soc., Chem. Commun., 232 (1993).
  • Wittig reaction (see Appendix 1) of the derived phosphorane with aldehydes and ketones gives enol ethers, readily hydrolyzed to homologous aldehydes. For an example (adamantanone to adamantanecarboxaldehyde), see: Chem. Ber., 95, 2514 (1962). For use of the reaction in the synthesis of hydroisoquinoline AMPA antagonists, see: J. Med. Chem., 39, 2219 (1996). Reaction with chiral 2,3-epoxyaldehydes provides an enantioselective synthesis of (E)-4-hydroxyalkenes: J. Chem. Soc., Chem. Commun., 232 (1993).

安全信息

Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P312+P330
  • P301+P317
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
WGK Germany3
GHS Symbol
Signal word
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
Hazard Codes Xn Xn,Xi Xi
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C, stored under nitrogen {LY} 2-8°C, stored under nitrogen {} {LY} 2-8°C, stored under nitrogen {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
UN Number UN 1390 4.3/PG 2

其他信息

  • MOL 文件:4009-98-7.mol
  • 海关编码:29310095
  • F:3-10
  • Sigma Aldrich:4009-98-7(sigmaaldrich)
  • (甲氧基甲基)三苯基氯化价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw060026 甲氧甲基三苯基氯化鏻 100g 400元 2011/04/16 M0828 (甲氧甲基)三苯基氯化 (Methoxymethyl)triphenylphosphonium Chloride 500G 3680元 2011/04/16 M0828 (甲氧甲基)三苯基氯化 (Methoxymethyl)triphenylphosphonium Chloride 25G 480元
  • 用途一:Wittig-试剂的前提物质,用于羰基化合物的甲氧基亚甲基化; 如用在合成类固醇、倍半萜化合物、前列腺索类似物。
  • 上游原料:甲苯 --> 三苯基膦 --> 氯甲基甲醚
  • 遇水分解.
  • Acros Organics:甲氧基甲基三苯基氯化磷 (Methoxymethyl)triphenylphosphonium chloride, 98%(4009-98-7)
  • MSDS 信息:(Methoxymethyl)triphenylphosphonium chloride(4009-98-7).msds
  • 敏感性:Hygroscopic
  • Hazard Note:Harmful
  • TCI Shanghai:(甲氧甲基)三苯基氯化 (Methoxymethyl)triphenylphosphonium Chloride,>;97.0%(LC)(T)(4009-98-7)
  • Alfa Aesar:氯化甲氧基甲基三苯基磷盐,98+% (Methoxymethyl)triphenylphosphonium chloride, 98+%(4009-98-7)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Phosphorus Compounds 磷化合物
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. C-C Bond Formation - Synthetic Reagents
  4. Olefination - C-C Bond Formation
  5. Wittig Reagents - Olefination
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. C-C Bond Formation - Synthetic Reagents
  4. Olefination - C-C Bond Formation
  5. Wittig Reagents - Olefination
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. C-C Bond Formation - Synthetic Reagents
  4. Olefination - C-C Bond Formation
  5. Others - Olefination
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Wittig & Horner-Emmons Reaction
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Phosphonium Compounds

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