Acetylthiocholine iodide 2-乙酰硫基-N,N,N-三甲基乙铵碘化物

CAS 1866-15-5 MFCD00011819

化学结构图

1866-15-5
SMILES: CC(=O)SCC[N+](C)(C)C.[I-]

化学属性

Mol. FormulaC7H16INOS
Mol. Weight289.18
Melting Point205-210 °C
TSCAYes
Density1.422
SolubilitySoluble in water,
Appearance powder
Stability对湿度,光线和热敏感

别名和识别编码

Chemical NameAcetylthiocholine iodide
Synonym Acetylthiocholine (iodide) {LY} Acetylthiocholine (iodide) {} {LY} Acetylthiocholine (iodide) {} {} {LY} Acetylthiocholine (iodide) {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {} {} {}
CAS Number1866-15-5
PubChem Substance ID87561810
EC Number217-474-1
Beilstein Registry Number3916578
MDL NumberMFCD00011819
Reaxys-RN3916578
Chemical Name Translation2-乙酰硫基-N,N,N-三甲基乙铵碘化物
InChIKeyNTBLZMAMTZXLBP-UHFFFAOYSA-M
Wiswesser Line Notation1VS2K1&1&1 &I
LabNetwork Molecule IDLN00193842
Canonical SMILESO=C(SCC[N+](C)(C)C)C.[I-]
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分类

  • {SNA} Acetylcholinesterase, Enzyme Substrates, Substrates by Enzyme, 生化试剂, 酶、抑制剂和底物
  • A-AM, Acetylcholinesterase, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Enzyme Substrates, Enzymes, Inhibitors, and Substrates, Substrates by Enzyme
  • {SNA} A-AM, Agonists, Analytical and Industrial Enzymes, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cholinergics, Cholinesterase Substrates, Cholinesterase and Organophosphate Detection Reagents, Enzymes, Inhibitors, and Substrates, Ion Channels,
  • {SNA} Agonists,

产品应用

  • A nAChR agonist and substrate of acetylcholinesterase

相关文献及参考

  • Froede, H.C. J. Biol. Chem. 259 , 11010, (1984)
  • Beilstein: 4,IV,1585

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H301+H311
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H315 Causes skin irritation 会刺激皮肤
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes 6.1 T
RTECSFZ9865000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P302+P352+P312+P361+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P332+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
UN Number 2811 UN 2811 6.1/PG 3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Risk Statements
  • R21 Harmful in contact with skin 与皮肤接触有害
  • R25 Toxic if swallowed 吞咽有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C {LY} 2-8°C Light Sensitive & Hygroscopic Store at room temperature {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Packing GroupIII
Hazard Class6.1
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#02898

其他信息

  • TCI Shanghai:碘化硫代乙酰胆碱 Acetylthiocholine Iodide,>;98.0%(T)(1866-15-5)
  • 用途二:乙酰胆碱酯酶的底物,烟碱性乙酰胆碱受体激动剂。常用于色度法测定乙酰胆碱酯酶的活性。
  • 碘代硫代乙酰胆碱价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 K0148003 碘化乙酰硫代胆碱(+4℃) 25g 3390元 2011/08/23 SA575102 碘化硫代乙酰胆碱(-20℃) 1g 394元 2011/08/23 69000885 碘化乙酰硫代胆碱(+4℃) 1g 200元
  • Alfa Aesar:S-乙酰基硫代碘化胆碱,98% S-Acetylthiocholine iodide, 98%(1866-15-5)
  • 可燃性危险特性:可燃; 加热分解释放有毒硫氧化物,氮氧化物和碘化物烟雾
  • 类别:有毒物品
  • Acetylthiocholine iodide is an AChE (acetylcholinesterase) substrate and AChR (nicotinic acetylcholine receptor)agonist.
  • 毒性分级:中毒
  • 用途一:测定乙酰胆碱酯酶的底物 无公害蔬菜检测技术,生化生测(也称酶抑制法、快速农药残毒测定方法),目前此方法主要从家蝇或其他动物组织中提取乙酰胆碱酯酶,乙酰胆碱酯酶与蔬菜样本提取液混合,以碘化乙酰硫代胆碱(ATchI)为底物,二硫双硝基苯甲酸(DTNB)为显色剂,一段时间后比色,根据吸光值,计算乙酰胆碱受抑制程度。
  • color:white
  • 上游原料:氢氧化钠 --> 盐酸 --> 乙酸乙酯 --> 乙醚 --> 二氯甲烷 --> 氧氯化硫 --> 乙酐 --> 丙酮 --> 碳酸氢钠 --> 碘甲烷 --> 硫脲 --> N,N-二甲基乙醇胺 --> 2-甲胺乙硫醇盐酸盐 --> 硫代乙酸钾
  • 敏感性:Light Sensitive & Hygroscopic
  • 存储注意事项:光敏感
  • MOL 文件:1866-15-5.mol
  • 急性毒性:静脉-小鼠 LD50:1.800 毫克/公斤
  • 储运特性:库房通风低温干燥
  • 检测方法:TITR
  • F:3-8-10
  • Acros Organics:S-乙酰硫代碘化胆碱 S-Acetylthiocholine iodide, 98%(1866-15-5)
  • 溶于水,水中溶解度:0.1 g/mL
  • Sigma Aldrich:1866-15-5(sigmaaldrich)
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水

系列性分类


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