Acetylthiocholine iodide 2-乙酰硫基-N,N,N-三甲基乙铵碘化物

CAS 1866-15-5 MFCD00011819

化学结构图

1866-15-5
SMILES: CC(=O)SCC[N+](C)(C)C.[I-]

化学属性

Mol. FormulaC7H16INOS
Mol. Weight289.18
Melting Point205-210 °C
TSCAYes
Density1.422
SolubilitySoluble in water,
Appearance powder
Stability对湿度,光线和热敏感

别名和识别编码

Chemical NameAcetylthiocholine iodide
Synonym Acetylthiocholine (iodide) {LY} Acetylthiocholine (iodide) {} {LY} Acetylthiocholine (iodide) {} {} {LY} Acetylthiocholine (iodide) {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acetylthiocholine (iodide) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acetylthiochol
CAS Number1866-15-5
PubChem Substance ID87561810
EC Number217-474-1
Beilstein Registry Number3916578
MDL NumberMFCD00011819
Reaxys-RN3916578
Chemical Name Translation2-乙酰硫基-N,N,N-三甲基乙铵碘化物
InChIKeyNTBLZMAMTZXLBP-UHFFFAOYSA-M
Wiswesser Line Notation1VS2K1&1&1 &I
LabNetwork Molecule IDLN00193842
Canonical SMILESO=C(SCC[N+](C)(C)C)C.[I-]
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分类

  • {SNA} Acetylcholinesterase, Enzyme Substrates, Substrates by Enzyme, 生化试剂, 酶、抑制剂和底物
  • A-AM, Acetylcholinesterase, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Enzyme Substrates, Enzymes, Inhibitors, and Substrates, Substrates by Enzyme
  • {SNA} A-AM, Agonists, Analytical and Industrial Enzymes, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cholinergics, Cholinesterase Substrates, Cholinesterase and Organophosphate Detection Reagents, Enzymes, Inhibitors, and Substrates, Ion Channels,
  • {SNA} Agonists,

产品应用

  • A nAChR agonist and substrate of acetylcholinesterase

相关文献及参考

  • Froede, H.C. J. Biol. Chem. 259 , 11010, (1984)
  • Beilstein: 4,IV,1585

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H301+H311
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H315 Causes skin irritation 会刺激皮肤
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes 6.1 T
RTECSFZ9865000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P302+P352+P312+P361+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P332+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
UN Number 2811 UN 2811 6.1/PG 3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R21 Harmful in contact with skin 与皮肤接触有害
  • R25 Toxic if swallowed 吞咽有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C {LY} 2-8°C Light Sensitive & Hygroscopic Store at room temperature {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY}
Packing GroupIII
Hazard Class6.1 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#02898

其他信息

  • TCI Shanghai:碘化硫代乙酰胆碱 Acetylthiocholine Iodide,>;98.0%(T)(1866-15-5)
  • 用途二:乙酰胆碱酯酶的底物，烟碱性乙酰胆碱受体激动剂。常用于色度法测定乙酰胆碱酯酶的活性。
  • 碘代硫代乙酰胆碱价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 K0148003 碘化乙酰硫代胆碱(+4℃) 25g 3390元 2011/08/23 SA575102 碘化硫代乙酰胆碱（-20℃） 1g 394元 2011/08/23 69000885 碘化乙酰硫代胆碱（+4℃） 1g 200元
  • Alfa Aesar:S-乙酰基硫代碘化胆碱,98% S-Acetylthiocholine iodide, 98%(1866-15-5)
  • 可燃性危险特性:可燃; 加热分解释放有毒硫氧化物,氮氧化物和碘化物烟雾
  • 类别:有毒物品
  • Acetylthiocholine iodide is an AChE (acetylcholinesterase) substrate and AChR (nicotinic acetylcholine receptor)agonist.
  • 毒性分级:中毒
  • 用途一:测定乙酰胆碱酯酶的底物 无公害蔬菜检测技术,生化生测（也称酶抑制法、快速农药残毒测定方法）,目前此方法主要从家蝇或其他动物组织中提取乙酰胆碱酯酶，乙酰胆碱酯酶与蔬菜样本提取液混合，以碘化乙酰硫代胆碱（ATchI）为底物，二硫双硝基苯甲酸（DTNB）为显色剂，一段时间后比色，根据吸光值，计算乙酰胆碱受抑制程度。
  • color:white
  • 上游原料:氢氧化钠 --> 盐酸 --> 乙酸乙酯 --> 乙醚 --> 二氯甲烷 --> 氧氯化硫 --> 乙酐 --> 丙酮 --> 碳酸氢钠 --> 碘甲烷 --> 硫脲 --> N,N-二甲基乙醇胺 --> 2-甲胺乙硫醇盐酸盐 --> 硫代乙酸钾
  • 敏感性:Light Sensitive & Hygroscopic
  • 存储注意事项:光敏感
  • MOL 文件:1866-15-5.mol
  • 急性毒性:静脉-小鼠 LD50:1.800 毫克/公斤
  • 储运特性:库房通风低温干燥
  • 检测方法:TITR
  • F:3-8-10
  • Acros Organics:S-乙酰硫代碘化胆碱 S-Acetylthiocholine iodide, 98%(1866-15-5)
  • 溶于水，水中溶解度：0.1 g/mL
  • Sigma Aldrich:1866-15-5(sigmaaldrich)
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. A-AM - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Ligand-Gated Ion Channels - Ion Channels
  6. Nicotinic Acetylcholine Receptor Modulators - Ligand-Gated Ion Channels
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Substrates - Enzymes, Inhibitors, and Substrates
  5. Substrates by Enzyme - Enzyme Substrates
  6. Acetylcholinesterase - Substrates by Enzyme
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Substrates - Enzymes, Inhibitors, and Substrates
  5. Substrates by Enzyme - Enzyme Substrates
  6. Acetylcholinesterase - Substrates by Enzyme
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Quaternary Ammonium Compounds 季铵化合物
  1. Functional Group 官能团索引
  2. quaternary ammonium salt
  1. Functional Group 官能团索引
  2. thiocarboxylic acid ester
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Neuroscience
  5. Ion Channels
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Ion Channels
  5. Ligand-Gated Ion Channels
  6. Ionotropic Glutamate Receptor Modulators

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