2-((Hydroxyimino)Methyl)-1-Methylpyridin-1-Ium Chloride 1-甲基吡啶-2-醛肟氯鎓盐

CAS 51-15-0 MFCD00011981

化学结构图

51-15-0
SMILES: C[n+]1ccccc1/C=N/O.[Cl-]

化学属性

Mol. FormulaC7H9ClN2O
Mol. Weight173
Melting Point230 °C(lit.)
TSCANo
Solubility65.5 G/100 ML (25 ºC)
Appearance 黄白色结晶性粉末。熔点235-238℃（分解）。在25℃水中溶解度为640mg/ml。

别名和识别编码

Chemical Name2-((Hydroxyimino)Methyl)-1-Methylpyridin-1-Ium Chloride
CAS Number51-15-0
Synonym 1-Methylpyridinium-2-aldoxime Chloride 1-methyl-2-formylpyridiniumchlorideoxime Pyridinium, 2-((hydroxyimino)methyl)-1-methyl-, chloride 1-methyl-2-aldoximinopyridiniumchloride 1-Methyl-2-formylpyridinium chloride oxime 2-(Hydroxyiminomethyl)-1-methylpyridinium chloride PYRIDINE-2-CARBOXALDOXIME METHOCHLORIDE 2-[(Hydroxyimino)methyl]-1-methylpyridiniumchloride 2-Formy 2-PAM chloride 2-PYRIDINEALDOXIME METHOCHLORIDE 1-methyl-2-pyridiniumaldoximechloride {Chemicalb N-Methylpyridinium chloride 2-aldoxime 2-吡啶醛 2-吡啶醛肟 甲氯, 97% 2-Pam 2-Pyridine-aldoxime chloride PYRIDINE-2-CARBALDOXIME METHOCHLORIDE 2-Formyl-1-methyl-pyridinium Chloride Oxime Protopam Chloride 1-Methyl-2-aldoximinopyridinium chloride 2-Formyl-1-methylpyridinium chloride oxime 1-Methyl-2-pyridinium aldoxime chloride Pyridinium aldoxime methochloride 2-PAM 氯化物 氯解磷定 PYRIDINE-2 {C 2-PAM chloride; Pralidoxime chloride Protopam chloride 2-pyridinealdoximemethylchloride 吡啶-2-甲醛肟甲氯化物 n-methylpyridiniumchloride2-al Pralidoxime chloride 2-吡啶醛肟甲氯 {h 2-[(Hydroxyimino)methyl]-1-methyl-pyridinium Chloride 2-formyl-1-methylpyridiniumchlorideoxime 1-METHYLPYRIDINIUM-2-ALDOXIME CHLORIDE 2-Pyridinealdoxime Metho Pyridine-2-aldoxime methochloride 2-PAM 2-(hydroxyiminomethyl 消磷灵 吡啶-2-甲醛肟氯甲烷盐 N-METHYLPYRIDINIUM-2-ALDOXIME CHLORIDE PAM CHLORIDE 氯解磷定
MDL NumberMFCD00011981
PubChem Substance ID135445761
EC Number200-080-9
Merck Number7703
Beilstein Registry Number4163981
Reaxys-RN4163981
Chemical Name Translation1-甲基吡啶-2-醛肟氯鎓盐
Wiswesser Line NotationT6KJ A1 B1UNQ &G
InChIKeyHIGSLXSBYYMVKI-UHFFFAOYSA-N
InChIInChI=1S/C7H8N2O.ClH/c1-9-5-3-2-4-7(9)6-8-10;/h2-6H,1H3;1H
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分类

  • {SNA} Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Substrate Analogs
  • Neurochemicals
  • {SNA} Analytical and Industrial Enzymes, Biochemicals and Reagents, Cholinesterase and Organophosphate Detection Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Oxime-Based Reactivators of Cholinesterase, Substrate Analogs, 酶、抑制剂和底物
  • Pharmaceuticals
  • {SNA} Analytical and Industrial Enzymes, Biochemicals and Reagents, C
  • Intermediates & Fine Chemicals
  • {SNA} Analytical and Industrial Enzymes, Cholinesterase and Organophosphate Detection Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Oxime-Based Reactivators of Cholinesterase, Substrate Analogs, 生化试剂,

产品应用

  • This compound binds to inactivated acetylcholinesterases and is used to combat poisoning from organophosphates and nerve agents

相关文献及参考

  • Lajmanovich, R., et al.: Toxicol. Env. Chem., 90, 1145 (2008),
  • Eyer, P., et al.: Brit. J. Clin. Pharmacol., 66, 450 (2008),

安全信息

WGK Germany1
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P302+P352+P332+P313+P362+P364
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P332+P313
  • P305+P351+P338+P337+P313
  • P302+P350
  • P337+P313
  • P305+P351+P338
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H303 May be harmfully swallowed 吞食可能有害
RTECSUU4200000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
Hazard Codes Xn
Storage condition 0-6°C 
{h

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 14,5,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 14 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Lungs, Thorax, or Respiration - bronchiolar constriction
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volume(issue)/page/year: -,449,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 96 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   16,40,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 8,431,1985

其他信息

  • 上游原料:乙醇溶液 --> 2-甲基吡啶 --> 亚硝酸乙酯
  • TCI Shanghai:1-甲基吡啶-2-醛肟氯盐 1-Methylpyridinium-2-aldoxime Chloride,>;97.0%(T)(51-15-0)
  • 2-吡啶醛肟甲氯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0819 1-甲基吡啶-2-醛肟氯盐 1-Methylpyridinium-2-aldoxime Chloride 25G 652元 2010/06/21 157670050 2-吡啶醛肟甲氯 2-Pyridinealdoxime methochloride 99% 5 GR 495元 2010/05/25 B23890 2-吡啶醛肟 甲氯, 97% Pyridine-2-carboxaldoxime methochloride, 97% 25g 1596元
  • Alfa Aesar:2-吡啶醛肟甲氯,97% Pyridine-2-carboxaldoxime methochloride, 97%(51-15-0)
  • MOL 文件:51-15-0.mol
  • 下游产品:2-吡啶乙肪醛甲碘化物
  • 2-吡啶醛肟甲氯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 M0819 1-甲基吡啶-2-醛肟氯盐 1-Methylpyridinium-2-aldoxime Chloride 25G 1010元 2010/06/21 157670050 2-吡啶醛肟甲氯 2-Pyridinealdoxime methochloride 99% 5 GR 495元 2010/05/25 B23890 2-吡啶醛肟 甲氯, 97% Pyridine-2-carboxaldoxime methochloride, 97% 25g 1596元
  • 用途一:用于有机磷中毒的解毒剂。
  • Sigma Aldrich:51-15-0(sigmaaldrich)
  • 方法一:2-甲基吡啶与氯甲烷反应得2-甲基吡啶氯甲烷盐，使基与亚硝酸乙酯进行亚硝化反应得到氯解磷定钠盐，然后在乙醇溶液中用浓盐酸中和至pH=3-4，滤去氯化钠，滤液减压浓缩回收乙醇，得氯解磷定粗品，经蒸馏水溶解、活性炭脱色、重结晶得成品。
  • 图谱信息:2-吡啶醛肟甲氯(51-15-0)核磁图( 13 CNMR) 2-吡啶醛肟甲氯(51-15-0)红外图谱(IR2) 2-吡啶醛肟甲氯(51-15-0)核磁图( 1 HNMR) 2-吡啶醛肟甲氯(51-15-0)红外图谱(IR1) 2-吡啶醛肟甲氯(51-15-0)质谱(MS)
  • Acros Organics:2-吡啶醛肟甲氯 2-Pyridinealdoxime methochloride, 99%(51-15-0)

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Substrate Analogs - Enzyme Inhibitors by Type
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Substrate Analogs - Enzyme Inhibitors by Type
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Pyridinium Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyridines 吡啶

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