Auramine O 金胺 O

CAS 2465-27-2 MFCD00012484

化学结构图

2465-27-2
SMILES: CN(C)c1ccc(C(=N)c2ccc(N(C)C)cc2)cc1.Cl

化学属性

Mol. FormulaC17H22ClN3
Mol. Weight303.83
Density1.01
Melting Point>250 °C
TSCAYes
Appearance 黄色均匀粉末。溶于冷水，易溶于热水呈亮黄色，煮沸即分解。溶于乙醇呈黄色。染料粉末于浓硫酸中呈无色，稀释后转浅黄色；于浓硝酸中呈橙色；于氢氧化钠溶液中成白色沉淀。

别名和识别编码

Chemical NameAuramine O
Synonym Auramine O {LY} Auramine O {} {LY} Auramine O {} {} {LY} Auramine O {} {} {} {LY} Auramine O {} {} {} {} {LY} Auramine O {} {} {} {} {} {LY} Auramine O {} {} {} {} {} {} {LY} Auramine O {} {} {} {} {} {} {} {LY} Auramine O {} {} {} {} {} {} {} {} {LY} Auramine O {} {} {} {} {} {} {} {} {} {LY} Auramine O {} {} {} {} {} {} {} {} {} {} {LY} Auramine O {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Auramine O {} {} {} {} {} {} {} {} {} {} {} {} {LY} Auramine O {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Auramine O {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Auramine O {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Auramine O {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Auramine O {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Auramine O {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number2465-27-2
EC Number219-567-2
Beilstein Registry Number4030061
MDL NumberMFCD00012484
PubChem Substance ID17170
Reaxys-RN4030061
Chemical Name Translation金胺 O
Wiswesser Line Notation1N1&R DYUM&R DN1&1 &GH
LabNetwork Molecule IDLN00195140
InChIInChI=1S/C17H21N3.ClH/c1-19(2)15-9-5-13(6-10-15)17(18)14-7-11-16(12-8-14)20(3)4;/h5-12,18H,1-4H3;1H
Canonical SMILESN=C(C1=CC=C(N(C)C)C=C1)C2=CC=C(N(C)C)C=C2.[H]Cl
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分类

  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 2fragments; ionic
  • {SNA} Biochemicals and Reagents, Fluorescent Labels, Fluorescent Probes, Labels, Particles and Stains, Other Fluorescent Labels
  • {SNA} A, Biochemicals and Reagents, Certified Stains & Dyes, Fluorescent Labels, Fluorescent Probes, Labels, Particles and Stains, Hematology and Histology, Other Fluorescent Labels, Stains & Dyes, A to Z, Stains and Dyes, 细胞生物学
  • {Chemicalbook} 染料: 阳离子染料: 一般碱性染料
  • {SNA} A,
  • {SNA} Fluorescent L
  • {SNA} A, Certified Stains & Dyes, Fluorescent Labels, Other Fluorescent Labels, Stains & Dyes, A to Z, Stains and Dyes, 生化试剂, 细胞生物学, 荧光探针，标记，粒子

产品应用

  • 主要应用于结核杆菌等抗酸性菌的荧光染色。抗酸性菌用荧光染料Auramine O(金胺O)染色后，用含有紫外光源的荧光显微镜检查，将会发出闪亮的橘黄颜色。这种方法可用较低倍镜检，因此能更快速找出抗酸性菌。

相关文献及参考

  • Short: II/3
  • Short: EINECS
  • Beilstein:14(3)227

安全信息

Signal word Danger Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R24 Toxic in contact with skin 与皮肤接触有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P350
  • P305+P351+P338
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P337+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
  • H302 Harmful if swallowed 吞食有害
  • H311 Toxic in contact with skin 皮肤接触中毒
RTECSBY3675000
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes 6.1 T
UN Number 2811 UN 2811 6.1/PG 3
Packing GroupIII
Storage condition RT, sealed storage, away from moisture and light {LY} RT, sealed storage, away from moisture and light {} {LY} RT, sealed storage, away from moisture and light {} {} {LY} RT, sealed storage, away from moisture and light {} {} {} {LY} RT, sealed storage, away from moisture and light {} {} {} {} {LY} RT, sealed storage, away from moisture and light {} {} {} {} {} {LY} RT, sealed storage, away from moisture and light {} {} {} {} {} {} {LY} RT, sealed storage, away from moisture and light {} {} {} {} {} {} {} {LY} RT, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {LY} RT, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {LY} RT, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {}
Hazard Class6.1 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 32760 mg/kg/39W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-0588-0730

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 440 mg/kg/21W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   16,87,1962

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 40 gm/kg/87W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/p

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 40 gm/kg/87W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2X

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - domestic
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CWLTM* Chemical Warfare Laboratories Technical Memorandum.  (U.S. Army
   Chemical Center, Edgewood Arsenal, MD 21010)  Volume(issue)/page/year:
   #47-6,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CRDLP* U.S. Army Chemical Research & Development Laboratory, Special
   Publication.  (Edgewood Arsenal, MD 21010)  Volume(issue)/page/year:
   4-59,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 480 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CRDLP* U.S. Army Chemical Research & Development Laboratory, Special
   Publication.  (Edgewood Arsenal, MD 21010)  Volume(issue)/page/year:
   4-59,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CWLTM* Chemical Warfare Laboratories Technical Memorandum.  (U.S. Army
   Chemical Center, Edgewood Arsenal, MD 21010)  Volume(issue)/page/year:
   #47-6,1959

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 7500 ug/kg
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 9,941,1982

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 2 mg/plate
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 2,1317,1981

TYPE OF TEST            : Morphological transformation
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 4914 mg/kg
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-0588-0730

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 30 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 20 umol/L/5H (Continuous)
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher in

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 3 umol/L
REFERENCE :
   SinJF# Personal Communication from J.F. Sina, Merck Institute for
   Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
   Volume(issue)/page/year: 26OCT1982

其他信息

  • MOL 文件:2465-27-2.mol
  • 储运特性:库房通风低温干燥；与氧化剂， 食品原料分开存放
  • 色指数:41000
  • 可燃性危险特性:明火可燃; 受热分解释出有毒氮氧化物气体
  • 类别:有毒物质
  • 用途三:主要应用于结核杆菌等抗酸性菌的荧光染色。抗酸性菌用荧光染料Auramine O(金胺O)染色后，用含有紫外光源的荧光显微镜检查，将会发出闪亮的橘黄颜色。这种方法可用较低倍镜检，因此能更快速找出抗酸性菌。
  • 毒性分级:高毒
  • Acros Organics:金胺/生化染色剂/碱性嫩黄0 Auramine O, biological stain, pure(2465-27-2)
  • TCI Shanghai:金胺 Auramine,>;80.0%(LC)(T)(2465-27-2)
  • Sigma Aldrich:2465-27-2(sigmaaldrich)
  • 方法一:方法 1：熔烧法 以 N，N-二甲基苯胺为主要原料，首先与甲醛缩合得二芳基甲烷，经蒸馏、结晶精制后，用尿素、硫磺、氯化铵氨化后经过滤、干燥即得成品。。 氨化反应实际为硫化、亚氨化和成盐三步反应一步完成，即将 4，4 ' -二甲氨基二苯甲烷、硫磺、尿素和氯化铵按比例加入氨化釜，升温至 (200±5)℃，反应 4h，出料即得。 方法 2：溶剂法 新近研制的溶剂法以乙二醇为溶剂，使反应温度降低，收率大幅度提高。反应过程如下：。 于反应釜中投入乙二醇 300g、硫磺 58g，于 (140±5)℃通入氨气，反应 4h 后加入氯化铵 80g，继续通氨气反应 16h，总通氨气量约 102g。反应结束，冷却，结晶，过滤，烘干，得产品约 155g。
  • 灭火剂:二氧化碳、砂土、泡沫、雾状水
  • 急性毒性:口服- 小鼠 LD50: 480 毫克/ 公斤; 腹腔- 大鼠 LD50:135 毫克/ 公斤
  • 用途一:碱性嫩黄 O 可用于蚕丝、棉、腈纶、羊毛等的染色，也用于直接印花，使用时，溶解温度不宜超过 60℃。由于其日晒牢度等太差，因此在纺织品上已较少使用。可用于皮革、纸张、涂料等的着色。
  • 上游原料:N,N-二甲基苯胺 --> 对氨基苯磺酸 --> 二苯甲胺
  • 溶于冷水，易溶于热水呈亮黄色，溶于乙醇呈黄色，其水溶液温度超过70℃时会分解为四甲基苯甲酮，其水溶液加入浓硫酸呈无色，稀释后呈淡黄色。水中溶解度:10 g/l (20°C)。溶于DMF、丙酮 。
  • 方法二:由N,N-二甲基苯胺与甲醛进行缩合，经蒸馏、结晶精制后，用硫磺、尿素与氯化铵进行氨化，而后过滤、干燥即得成品。原料消耗(kg/t)N,N-二甲基苯胺（98%） 110甲醛（37%） 460尿素 700硫磺（99%） 350氯化铵 630对氨基苯磺酸（100%） 8精盐 7500
  • 金胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 71004180 金胺 O 5g 168元 2011/04/16 A0334 金胺 Auramine 25G 204元 2010/06/21 227520500 金胺 Auramine O , pure, biological stain 50 GR 1013元
  • 用途二:用于乙酸纤维、媒染棉，但牢度低，色泽鲜艳，可用来拼制绿色或红色等。也可用于皮革、纸、麻和粘胶的染色。碱性本可用于油、脂肪、油漆等的着色。还可制备色淀，用于油墨。
  • 图谱信息:金胺(2465-27-2)核磁图( 13 CNMR) 金胺(2465-27-2)质谱(MS) 金胺(2465-27-2)核磁图( 1 HNMR) 金胺(2465-27-2)红外图谱(IR2) 金胺(2465-27-2)红外图谱(IR1)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Specialty Gases 特种气体
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Fluorescent Probes, Labels, Particles and Stains - Biochemicals and Reagents
  4. Fluorescent Labels - Fluorescent Probes, Labels, Particles and Stains
  5. Other Fluorescent Labels - Fluorescent Labels
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Fluorescent Probes, Labels, Particles and Stains
  4. Fluorescent Labels
  5. Fluorescein and Derivatives
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Luminescent Compounds/Detection
  4. Fluorescent Probes, Labels, Particles and Stains
  5. Fluorescent Labels
  6. Fluorescein and Derivatives

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