1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (hydrochloride) 1-乙基-3-(3-二甲基氨基丙基)碳酰二亚胺盐酸盐

CAS 25952-53-8 MFCD00012503

化学结构图

25952-53-8
SMILES: CCN=C=NCCCN(C)C.Cl

化学属性

Mol. FormulaC8H18ClN3
Mol. Weight191.70
Melting Point110-115°C
TSCAT
Density0.877
Refractive index1.461
Stability易吸潮
Boiling Point197.7°C at 760 mmHg
pH:A

别名和识别编码

Chemical Name1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (hydrochloride)
CAS Number25952-53-8
Alfabeta NameETHYLIMINOMETHYLENEDIMETHYLPROPANEDIAMINEHYDROCHLORIDE NNN13313(())-----,,
MDL NumberMFCD00012503
Synonym 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (hydrochloride) {LY} 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (hydrochloride) {} {LY} 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (hydrochloride) {} {} {LY} 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (hydrochloride) {} {} {} {LY} 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (hydrochloride) {} {} {} {} {LY} 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (hydrochloride) {} {} {} {} {} {LY} 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (hydrochloride) {} {} {} {} {} {} {LY} 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (hydrochloride) {} {} {} {} {} {} {} {LY} 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (hydrochloride) {} {} {} {} {} {} {} {} {LY} 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (hydrochloride) {} {} {} {} {} {} {} {} {} {LY} 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (hy
PubChem Substance ID2723939
EC Number247-361-2
Beilstein Registry Number5764110
Chemical Name Translation1-乙基-3-(3-二甲基氨基丙基)碳酰二亚胺盐酸盐
Reaxys-RN5764110
InChIKeyFPQQSJJWHUJYPU-UHFFFAOYSA-N
LabNetwork Molecule IDLN00173825
InChIInChI=1S/C8H17N3.ClH/c1-4-9-8-10-6-5-7-11(2)3;/h4-7H2,1-3H3;1H
Canonical SMILESCN(C)CCCN=C=NCC.Cl
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分类

  • {SNA} Crosslinking, Heterobifunctional Cross-Linking Reagents, Protein Modification, Protein Structural Analysis, Proteomics
  • {SNA} Crosslinking, Heterobifunctional Cross-Linking Reagents, Protein Modification, 分子生物学, 蛋白质组学, 蛋白质结构分析
  • Crosslinking, Heterobifunctional Cross-Linking Reagents,

产品应用

  • 用于多肽缩合剂和交联剂，该品是水溶性碳二亚胺，主要用作多肽、蛋白质、核苷酸合成中的脱水剂，可实现快速多肽缩合反应的水溶性碳二亚胺型缩合剂。

相关文献及参考

  • For use in the acylation of phosphoranes, see (Cyanomethyl)­triphenyl­phosphonium chloride, A13096.
  • Drabick, J.J., et al., Covalent polymyxin B conjugate with human immunoglobulin G as an antiendotoxin reagent. Antimicrob. Agents Chemother. 42 , 583-588, (1998) 摘要
  • For use in the synthesis of cyclic derivatives of 3'-amino-3'-deoxyadenosine-5'-di- and triphosphates, see: Angew. Chem. Int. Ed., 33, 1394 (1994).
  • Dhaon, M.K., Synthesis of esters. J. Org. Chem. 47 , 1962, (1982)
  • Merck: 14,10328
  • Often used in conjunction with an additive such as HOBt (1-hydroxybenzotriazole hydrate) to suppress racemization; see, for example: Bull. Chem. Soc. Jpn., 55, 2165 (1982). A two-phase solvent system (dichloromethane-water or isopropyl acetate-water) has been found to give superior results in this type of peptide coupling: J. Org. Chem., 60, 3569 (1995). In a comparative study, submolar quantities HOBt in DMF-water gave good results: Chem. Lett., 1 (1997).
  • Thomas, J.O., et al., Altered arrangement of the DNA in injection-defective lambda bacteriophage. J. Mol. Biol. 123 , 149, (1978) 摘要
  • 'Water-soluble carbodiimide', widely used for peptide coupling (see Appendix 6), with the major advantage that excess reagent and the urea by-product can be easily removed by washing with dilute acid or water: J. Org. Chem., 26, 2525 (1961); J. Am. Chem. Soc., 87, 2492 (1965). For discussion of the mechanism of peptide coupling with this reagent, see: J. Am. Chem. Soc., 103, 7090 (1981).
  • Promotes various other N-acylation reactions such as the formation of N-acylsulfonamides from primary sulfonamides and N-protected amino acids in the presence of DMAP: Synlett,
  • Promotes various other N-acylation reactions such as the formation of N-acylsulfonamides from primary sulfonamides and N-protected amino acids in the presence of DMAP: Synlett, 1141 (1995).

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany3
Hazard Codes C Xi
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSFF2200000
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P332+P313
  • P302+P352+P332+P313+P362+P364
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P302+P350
  • P337+P313
  • P305+P351+P338+P337+P313
Signal word Danger Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R34 Causes burns 会导致灼伤
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture 2-8℃密闭保存。 Moisture Sensitive {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moi
UN Number 2735

其他信息

  • F:3-10-21
  • MOL 文件:7084-11-9.mol
  • 极易吸潮。水中溶解度:>20g/100ml 溶于乙醇。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Life Science 生命科学
  2. Proteomics 蛋白质组学
  3. Protein Structural Analysis - Proteomics
  4. Protein Modification - Protein Structural Analysis
  5. Crosslinking - Protein Modification
  6. Heterobifunctional Cross-Linking Reagents - Crosslinking
  1. Life Science 生命科学
  2. Proteomics 蛋白质组学
  3. Protein Structural Analysis - Proteomics
  4. Protein Sequencing - Protein Structural Analysis
  5. Reagents for Protein Sequencing - Protein Sequencing
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Condensation & Active Esterification
  1. Functional Group 官能团索引
  2. carbodiimide
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Peptide Synthesis
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteomics
  4. Protein Structural Analysis
  5. Protein Modification