1-(1-Naphthoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride 1-异丙氨基-3-(1-萘氧基)-2-丙醇盐酸盐

CAS 318-98-9 MFCD00012558

化学结构图

318-98-9
SMILES: CC(C)NCC(O)COc1cccc2ccccc12.Cl

化学属性

Mol. FormulaC16H21NO2· HCl
Mol. Weight295.80
Density1.422
Melting Point163-165°
TSCANo
Solubility可溶
Appearance 白色或类白色的结晶性粉末；无臭，味微甜后苦。盐酸普萘洛尔(318-98-9)在水或乙醇中溶解，在氯仿中微溶。 powder
Stability对光敏感

别名和识别编码

Chemical Name1-(1-Naphthoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride
CAS Number318-98-9
Alfabeta NamePROPRANOLOLHYDROCHLORIDE
MDL NumberMFCD00012558
Synonym (±)-1-Isopropylamino-3- (+/- (+/-)-1-ISOPROPYLAMINO-3-(1-NAPHTHYLOXY)-2-PROPANOL HYDROCHLORIDE (+/-)-PROPRANOLOL HY (±)-Propranolol hydrochloride (±)-[2-hydroxy-3-(naphthyloxy)propyl]isopropylammonium chloride (±)-盐酸普萘洛尔,99% 1-(1-Naphthyloxy)-2-hydroxy-3-isopropylaminopropane hydrochloride 1-(Isopropylamino)-3-(1-naphthoxy)-2-propanol hydrochloride 1-(Isopropylamino)-3-(1-naphthyloxy)propan-2-ol hydrochlorid 1-(Isopropylamino)-3-(1-naphthyloxy)propan-2-ol hydrochloride 1-(Isopropylamino)-3-(alpha-naphthoxy)-2-propanol hydrochloride 1-(isopropylamino)-3-(1-naphthyloxy)-2-propanohydrochloride 1-[ISOPROPYLAMINO]-3-[1-NAPHTHYLOXY]-2-PROPANOL HYDROCHLORIDE 1-异丙氨基-3-(1-萘氧基)-2-丙醇盐酸盐 1[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol Hydrochloride 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphth 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride AY 64043 AY-64043 Anaprilin Apsolol Avlocardyl Berkolol Beta Neg Caridolol Caridorol DL-Anapriline DL-PROPRANOLOL HCL 99% DL-PROPRANOLOL HYDROCHLORIDE Docitan Dociton Herzbase I 2065 Ikopal Inderal hydrochloride Inderol Kemi NCS-91523 Obsidan Oposim PROPANOLOL HYDROCH PROPRANOLOL HCL PROPRANOLOL HYDROCHLORIDE Propranolol chloride propranalol hydrochloride propranolol hydrochloride (INNM) {} {Chemicalbo {} {} {Chem {} {} {haz {Chemical
EC Number206-268-7
Beilstein Registry Number4164259
PubChem Substance ID62882
Merck Number14,7840
Chemical Name Translation1-异丙氨基-3-(1-萘氧基)-2-丙醇盐酸盐
Wiswesser Line NotationL66J BO1YQ1MY1&1 &GH
LabNetwork Molecule IDLN00150905
InChIInChI=1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H
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分类

  • {uni_hamburg} no charge; carbocycle; aromatic; large ring; fused rings; 6ring; 10ring; alcohol; ether; racemate; 2fragments; ionic
  • {SA} Amino Alcohols, Building Blocks, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds
  • Pharmaceuticals
  • {SNA} Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, AstraZeneca, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, P, Proteins and Derivatives
  • Amines
  • {SNA} Adrenergics,
  • {SNA} Adrenergics, Adrenergics - Antagonists,

产品应用

  • 校准仪器和装置；评价方法；工作标准；质量保证/质量控制

相关文献及参考

  • [2]. Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73.
  • [3]. Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338.
  • [4]. Munabi NC, et al. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan;5(1):45-55.
  • Bond, et al.: Nature, 213, 721 (1967),
  • Diamond, S., et al.: J. Clin. Pharmacol., 28, 193 (1988),
  • Hansteen, V., et al.: Br. Med. J., 284, 155 (1982),
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
  • Short: III/10b Title: Structure Data of Organic C

安全信息

Warnings IRRITANT
Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S22 Do not breathe dust 不要吸入粉尘；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECSUB7525000
Hazard Codes Xn Xn,Xi
Storage condition 储存温度2-8°C 2-8°C
Packing GroupIII
Hazard Class6.1(b)
UN Number 3249 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 208 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on seizure threshold
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 12(Suppl 6),969,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 417 mg/kg/1Y-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - bronchiolar constriction
REFERENCE :
   PRACAK Practitioner.  (Morgan-Grampian Ltd., 40 Beresford St., Woolwich,
   London SE18 6BQ, UK) V.1-    1868-  Volume(issue)/page/year: 229,663,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,733,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,

TYPE OF TEST            : LD50 - Lethal dose,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : female 8-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   PSCHDL Psychopharmacology (Berlin).  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.47-    1976-
   Volume(issue)/page/year: 79,148,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 48 mg/kg
SEX/DURATION            : female 25-34 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other neonatal measures or effects
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   JOPDAB Journal of Pediatrics.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63141) V.1-    1932-  Volume(issue)/page/year:
   91,808,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 10500 ug/kg
SEX/DURATION            : female 7 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 12,53,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       :

其他信息

  • Sigma Aldrich:3506-09-0(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. P - Bioactive Small Molecules
  1. Analytical & Chromatography 分析化学与色谱
  2. Syringes
  3. GC Manual Syringes - Syringes
  4. Liquid sampling - GC Manual Syringes
  5. Syringe with sample in the needle, 0.5 - 5 µL - Liquid sampling
  6. Hamilton Modified Microliter™ Syringes, 7000 Series - Syringe with sample in the needle, 0.5 - 5 µL
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Amino Alcohols - Oxygen Compounds
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adrenergic Receptor  (肾上腺素能受体)

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