Histamine Dihydrochloride 组胺二盐酸盐

CAS 56-92-8 MFCD00012703

化学结构图

56-92-8
SMILES: Cl.Cl.NCCc1cnc[nH]1

化学属性

Mol. FormulaC5H11Cl2N3
Mol. Weight184.07
Density1.14
Melting Point249-252°C
TSCAYes
Solubility可溶
Appearance 类白色结晶或白色结晶性粉末。熔点 249-252℃，可溶于水。 powder

别名和识别编码

Chemical NameHistamine dihydrochloride, 99%, reference material
CAS Number56-92-8
Alfabeta NameIMIDAZOLEETHANAMINEDIHYDROCHLORIDE H14---
MDL NumberMFCD00012703
Synonym Histamine (dihydrochloride) {LY} Histamine (dihydrochloride) Histamine Dihydrochloride Histamine Hydrochloride Peremin {} {LY} Histamine (dihydrochloride) {} {} {LY} Histamine (dihydrochloride) {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {}
EC Number200-298-4
Beilstein Registry Number3624116
Reaxys-RN3624116
PubChem Substance ID5818
Merck Number4719
Chemical Name Translation组胺二盐酸盐
Wiswesser Line NotationT5M CNJ D2Z &GH 2
LabNetwork Molecule IDLN00001627
InChIInChI=1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
Canonical SMILESNCCC1=CN=CN1.Cl.Cl
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分类

  • {SNA} Agonists, Amino Acid, Amino Acid Library, Bioactive Small Molecule Alphabetical Index, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, H, Histaminergics, Membrane Protein Biology Tools, Metabolic Libraries, Mistaminergics - Agonists, Neuroscience, Neurotransmission, Neurotransmitters, 代谢组学, 代谢通路, 代谢通路图中的代谢产物和辅酶分子, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
  • {SNA} Bioactive Small Molecule Alphabetical Index, Enzyme Substrates, H, Histamine-N-Methyltransferase,

产品应用

  • 多巴胺(dopamine)直接前体的天然异构体，酪氨酸羟化酶的产物

相关文献及参考

  • Fu, L.W., et al., Endogenous histamine stimulates ischemically sensitive abdominal visceral afferents through H1 receptors. Am. J. Physiol. 273(6 Pt 2) , 2726, (1997) 摘要
  • Merck:14,4719 Beilstein:25,315
  • Merck:14,4719
  • Merck 14 ,4719
  • Dale, H.H., et al.: J. Physiol., 41, 318 (1910); Oosting, E., et al.: Clin. Exp. Allergy, 20, 349 (1990); Hill, S.J., et al.: Pharmacol. Rev., 49, 253 (1997);

安全信息

Warnings IRRITANT
Signal word Danger
GHS Symbol
WGK Germany2
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R42/43
Precautionary statements
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P317
  • P333+P317
  • P337+P317
  • P342+P316
  • P362+P364
  • P403 Store in a well-ventilated place. 储存在通风良好的地方。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard Codes Xn Xn,Xi Xi
Hazard statements
  • H303 May be harmfully swallowed 吞食可能有害
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECSMS1575000
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moist
UN Number 3335 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1550 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   ACPMAP Actualites Pharmacologiques.  (Paris, France)  No.1-33, 1949-81. For
   publisher information, see JNPHAG.  Volume(issue)/page/year: 24,51,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 184 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 97,1117,1977

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >28 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - corneal damage
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JIDIAQ Journal of Infectious Diseases.  (Univ. of Chicago Press, Journals
   Div., POB 37005, Chicago, IL 60637)  V.1-    1904- Volume(issue)/page/year:
   42,473,1928

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2400 mg/kg
SEX/DURATION            : female 1-6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 6,179,1963

其他信息

  • Alfa Aesar:二盐酸组胺,98+% Histamine dihydrochloride, 98+%(56-92-8)
  • Acros Organics:组胺二盐酸盐 Histamine dihydrochloride, 99%(56-92-8)
  • MSDS 信息:2-(4-Imidazolyl)ethylamine dihydrochloride(56-92-8).msds
  • MOL 文件:56-92-8.mol
  • TCI Shanghai:组胺二盐酸盐 Histamine Dihydrochloride,>;99.0%(T)(56-92-8)
  • 检测方法:T,NMR
  • F:1-8-9
  • 图谱信息:组胺二盐酸盐(56-92-8)核磁图( 1 HNMR) 组胺二盐酸盐(56-92-8)红外图谱(IR2) 组胺二盐酸盐(56-92-8)核磁图( 13 CNMR) 组胺二盐酸盐(56-92-8)质谱(MS) 组胺二盐酸盐(56-92-8)红外图谱(IR1)
  • 组胺二盐酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 62013932 二盐酸组胺 5g 138元 2011/04/16 H0146 组胺二盐酸盐 Histamine Dihydrochloride 1G 130元 2011/04/16 H0146 组胺二盐酸盐 Histamine Dihydrochloride 25G 1220元
  • Hazard Note:Irritant
  • color:white to off-white
  • 用途一:生化试剂，用作测定组胺酶的底物。作为医药中间体用于药物制造等用途。
  • Sigma Aldrich:56-92-8(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Libraries - Metabolomics
  4. Amino Acid Library - Metabolic Libraries
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Homopiperidines 同哌啶
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Imidazoles 咪唑
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitters - Neurotransmission
  7. Histaminergics - Neurotransmitters
  8. Agonists - Histaminergics
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Substrates - Enzymes, Inhibitors, and Substrates
  5. Substrates by Enzyme - Enzyme Substrates
  6. Histamine-N-Methyltransferase - Substrates by Enzyme
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Substrates - Enzymes, Inhibitors, and Substrates
  5. Substrates by Enzyme - Enzyme Substrates
  6. Histamine-N-Methyltransferase - Substrates by Enzyme
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Imidazoles 咪唑
  5. C3 to C8 - Imidazoles
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Albumins and Transport Proteins
  4. Albumin
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Libraries
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Metabolomics
  5. Metabolic Libraries
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Pathways
  5. Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Glutathione Peroxidase
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Metabolomics
  5. Metabolic Pathways
  6. Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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