1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridinehydrochloride 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐

CAS 23007-85-4 MFCD00012790

化学结构图

23007-85-4
SMILES: Cl.CN1CC=C(CC1)C1C=CC=CC=1

化学属性

Mol. FormulaC12H15N.HCl
Mol. Weight209.72
Melting Point249.0 to 254.0 deg-C

别名和识别编码

Chemical Name1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridinehydrochloride
CAS Number23007-85-4
Synonym 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine Hydrochloride 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine hydrochloride 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 MPTP Hydrochloride MPTP hydrochloride NSC 139654 Hydrochloride
MDL NumberMFCD00012790
PubChem Substance ID253660522
Beilstein Registry Number3707312
Reaxys-RN3707312
Chemical Name Translation1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐
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分类

  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Dopaminergics, M, Neuroscience, Neurotransmission, Neurotra
  • Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Dopaminergics, M,

产品应用

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

相关文献及参考

  • [2]. Hsu K S, et al. Potentiation of MPTP by 4-Phenylpyridine on the Neuromuscular Blockade in Mouse Phrenic Nerve-Diaphragm. Neuropharmacology, 1993, 32, No. 9, 877-83.
  • [3]. Sun XL, et al. Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models. J Neuroinflammation. 2016 Jul 8;13(1):180.
  • Burns, R.S., et al., A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N -methyl-4-phenyl-1,2,3,6-tetrah
  • Burns, R.S., et al.: Proc. Natl. Acad.Sci. USA, 80, 4546 (1983),
  • Davis, G.C., et al., Chronic Parkinsonism secondary to intravenous injection of meperidine analogues. Psychiatry Res. 1 , 249-254, (1979) 摘要
  • Gainetdinov, R.R., et al., Increased MPTP neurotoxicity in vescular monoamine transporter 2 heterozygote knockout mice. J. Neurochem. 70 , 1973-1978, (1998)
  • Langston, J.W., et al., Chro

安全信息

RTECSUT8358950
GHS Symbol
Precautionary statements
  • P301+P310
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P301+P310+P330
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P405 Store locked up. 上锁保管。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P301+P312
  • P330 Rinse mouth. 漱口
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H301+H311+H331
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes
WGK Germany3
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置;
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
UN Number 3077
Hazard Class6.1
Storage condition <0°C
Packing GroupIII
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 53800 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 247,531,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 72 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
   Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.41-    1956-  Volume(issue)/page/year: 105,470,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 35 mg/kg
SEX/DURATION            : female 12-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - other hydrolases
REFERENCE :
   LIFSAK Life Sciences.  (Pergamon Press Inc., Maxwell House, Fairview Park,
   Elmsford, NY 10523) V.1-8, 1962-69; V.14-    1974- Volume(issue)/page/year:
   48,217,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 25 mg/kg
SEX/DURATION            : female 17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange
REFERENCE :
   JONRA9 Journal of Neurochemistry.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036) V.1-    1956-  Volume(issue)/page/year: 55,1427,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 40 mg/kg
SEX/DURATION            : female 15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 67,63,1991

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