Procaine Hydrochloride 4-氨基苯甲酸-2-(二乙氨基)乙酯单盐酸盐

CAS 51-05-8 MFCD00013000

化学结构图

51-05-8
SMILES: CCN(CC)CCOC(=O)c1ccc(N)cc1.Cl

化学属性

Mol. FormulaH2NC6H4CO2CH2CH2N(C2H5)2·HCl
Mol. Weight273
Melting Point154.0 to 157.0 deg-C
TSCAYes
Boiling Point195-196
Solubility可溶
Density1.422
Stability对光和空气敏感

别名和识别编码

Chemical NameProcaine Hydrochloride
Synonym Sevicaine Procaine hydrochloride 4-氨基苯甲酸-2-(二乙氨基)乙酯盐酸 Paracain Anesthesol Neocaine Cetain Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, monohydrochloride Aminocaine 2-(Diethylamino)ethyl 4-aminobenzoate hydrochloride Anestil Diethylaminoethanol 4-aminobenzoate hydrochloride Eugerase Lactocaine 4-Aminobenzoic Acid 2-(Diethylamino)ethyl Ester Hydrochloride; 2-(Diethylamino)ethyl 4-Aminobenzoate Hydrochloride Isocaine-asid Syncaine 2-二乙基氨基乙基 4-氨基苯甲酸酯 盐酸盐, 99%
MDL NumberMFCD00013000
CAS Number51-05-8
EC Number200-077-2
Merck Number7757
PubChem Substance ID5795
Beilstein Registry Number14(4)1138
Reaxys-RN3917802
Chemical Name Translation4-氨基苯甲酸-2-(二乙氨基)乙酯单盐酸盐
Wiswesser Line NotationZR DVO2N2&2 &GH
LabNetwork Molecule IDLN00335077
InChIInChI=1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H
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分类

  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Celgene, Cell Biology, Cell Signaling and Neuroscience, DNA Methyltransferase Inhibitors, Epigenetics, Ion Channels, Molecular Biology, Monovalent Ion Channels, Non-nucleoside analog inhibitors, Other Sodium Channel Modulators, P, Sodium Channel Modulators, Voltage-gated Ion Channels
  • {SNA} Analytical Standards, EP Standards, EP Standards P - R, Pharmacopeia & Metrological Insti
  • {SNA} Additional Standards, Analytical Standards, Anesthetics Standards, Antibiotics Standards, Chemical Structure,
  • {SNA} Analytical Standards,

产品应用

  • A sodium channel blocker and DNA methylation inhibitor

相关文献及参考

  • Merck: 14,7757
  • Merck: 14,7757 Beilstein:14(4)1138

安全信息

Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Packing GroupIII
UN Number 2811
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R25 Toxic if swallowed 吞咽有毒
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Storage condition 充氩保存 Air Sensitive
RTECSDG2275000
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310+P330
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P301+P310
  • P405 Store locked up. 上锁保管。
  • P301+P310+
  • P305+P351+P338+P337+P313
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P302+P352+P332+P313+P362+P364
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H301 Toxic if swallowed 吞食有毒
WGK Germany3
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Signal word Danger
Hazard Codes T 6.1
Hazard Class6.1
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 192 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ANTCAO Antibiotics and Chemotherapy (Washington, DC).  (Washington, DC)
   V.1-12, 1951-62.  For publisher information, see CLMEA3.
   Volume(issue)/page/year: 4,633,1954

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 11 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 9,137,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZENBAX Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie,
   Organische Chemie, Biochemie, Biophysik, Biologie.  (Tuebingen, Fed. Rep.
   Ger.)  V.2B-27B, 1947-1972.  For publisher information, see ZNCBDA.
   Volume(issue)/page/year: 6B,183,1951

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 9,332,1954

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其他信息

  • 无臭,味微苦,随后有麻痹感。本品在水中易溶,略溶于乙醇,微溶于氯仿,不溶于乙醚。
  • Procaine HCl是一种钠离子通道的,NMDA受体以及乙酰胆碱受体抑制剂, IC50分别为60 μM, 0.296 mM何45.5 μM,也是一种,5-HT3抑制剂,KD为1.7 μM。

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