DL-Norephedrine hydrochloride 盐酸苯丙醇胺溶液,

CAS 154-41-6 MFCD00013019

化学结构图

154-41-6
SMILES: C[C@@H](N)[C@@H](O)c1ccccc1.Cl

化学属性

Mol. FormulaC6H5CH(OH)CH(NH2)CH3· HCl
Mol. Weight187.67
Melting Point194-196 °C(lit.)
Density1.071

别名和识别编码

Chemical Name100ppm DL-Norephedrine Hydrochloride
Synonym DL-2-氨基-1-苯基-1-丙醇盐酸盐 (+-)-2-Amino-1-phenyl-1-propanol hydrochloride 盐酸苯丙醇胺 DL-NOREPHEDRINE HYDROCHLORIDE Propadrine hydrochloride α-(1-氨基乙基)苯甲醇盐酸盐 [R*,S*]-[+/-]-ALPHA-[AMINOETHYL]BENZENEMETHANOL HYDROCHLORIDE DL-ERYTHRO-2-AMINO-1-PHENYL-1-PROPANOL HYDROCHLORIDE (+/-)-PHENYLPROPANOLAMINE HYDROCHLORIDE Obestat dl-2-amino-1-phenyl-1-propanol hydrochloride A-HYDROXY-B-AMINOPROPYLBENZENEHYDROCHLORIDE Monydrin IP 58064 盐酸DL-降麻黄碱 DL-1-PHENYL-2-A DL-PHENYLPROPANOLAMINE HYDROCHLORIDE 2-AMINO-1-PHENYL-1-PROPANOL HYDROCHLORIDE NOREPHEDRINE HCL DL-1-PHENYL-2-AMINO-1-PROPANOLYDROCHLORIDE PHENYLPROPANOLAMINE HYDROCHLORIDE 2-AMINO-1-HYDROXY-1-PHENYLPROPANE HYDROCHLORIDE (+/-)-NOREPHEDRINE HYDROCHLORIDE DL-PHENYLPROPANOLAMINE HCL (+-)-Phenylpropanolamine hydrochloride 盐酸苯丙醇胺,α-(1-氨基乙基)苯甲醇盐酸盐 Benzenemethanol, alpha-(1-aminoethyl)-, hydrochloride, (R*,S*)-, (+-) NOREPHEDRINE HYDROCHLORIDE (+/-)-Phenylpropanolamine hydrochloride; DL-2-Amino-1-phenyl-1-propanol hydrochloride DL-去甲麻黄素 盐酸盐 去甲麻黄素 ALPHA-(1-AMINOETHYL)BENZYL ALCOHOL HYDROCHLORIDE DL-1-Phenyl-2-amino-1-propanol monohydrochloride DL-苯丙醇胺盐酸盐 alpha-Hydroxy-beta-aminopropylbenzene hydrochloride Mucorama PHENYLPROPANOLAMINE HCL [+/-]-NOREPHEDRINE HYDROCHLORIDE dl-Norephedrine hydrochloride PHENYLPROPANOLAMINI HYDROCHLORIDUM (±)-苯丙醇胺 盐酸盐 DL-苯丙醇胺 盐酸盐 DL-赤型-2-氨基-1-苯基-1-丙醇 盐酸盐 赤型-2-氨基-1-苯基-1-丙醇 盐酸盐 右旋盐酸去甲麻黄碱
MDL NumberMFCD00013019
Beilstein Registry Number3914299
EC Number205-826-7
PubChem Substance ID9065
CAS Number154-41-6
Chemical Name Translation盐酸苯丙醇胺溶液,
Merck Number13,7391
Wiswesser Line NotationZY1&YQR &GH -R
InChIInChI=1S/C9H13NO.ClH/c1-7(10)9(11)8-5-3-2-4-6-8;/h2-7,9,11H,10H2,1H3;1H
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分类

  • {SA} Alkaloid, Amino Alcohols, Building Blocks, Chemical Synthesis, Nutrition Research, Organic Building Blocks, Oxygen Compounds, Phytochemicals by Chemical Classification
  • {SNA} Alkaloid, Bioactive Small Molecules, Catecholamine, Cell Biology, Cell Signaling and Neuroscience, Cofactor, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Metabolomics, N, Neurobiology, Neuroscience, Nutrition Research, Pharmacologicals, Phytochemicals by Chemical Classification, Stimulants
  • {SNA} Alkaloid, Catecholamine,

产品应用

  • 本品为鼻减充血剂，减食欲剂。

相关文献及参考

  • Merck:13,7391 Beilstein: 13,II,371
  • Merck:13,7391

安全信息

GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
RTECSDN4200000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Hazard Codes Xn
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S22 Do not breathe dust 不要吸入粉尘；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
UN Number 2811 UN 2811
Restrict 易制毒化学品 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1490 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 86,280,1946

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 275 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 71,62,1941

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 6400 ug/kg
SEX/DURATION            : female 16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   PRGLBA Prostaglandins.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1972-  Volume(issue)/page/year: 2,295,1972

其他信息

  • 下游产品:安心酮
  • 方法一:美国专利2151517叙述的方法是：取10.7公斤苯甲醛与11.0公斤亚硫酸氢钠的50升水溶液强力振摇，直至加成产物完全生成。同时，取8.25公斤硝基乙烷溶于4.5公斤苛性苏打的20升水溶液中，将所得热溶液在强力搅拌下加至苯甲亚硫酸氢钠的稠液中，混合振摇半小时后放置过夜，从浮于上层的油状苯基硝基丙醇中，用11.0公斤亚硫酸氢钠的50升水溶液除少量未反应的苯甲醛。所得苯基硝基丙醇为无公油状物。重17.1-17.7公斤，沸点150-165℃（0.665千帕）。将基氢化并转化为盐酸盐，即为盐酸苯丙醇胺。
  • 盐酸苯丙醇胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 157570050 盐酸苯丙醇胺 DL-Norephedrine hydrochloride 99+% 5 GR 164元 2010/06/21 157575000 盐酸苯丙醇胺 DL-Norephedrine hydrochloride 99+% 500 GR 974元 2010/06/21 157571000 盐酸苯丙醇胺 DL-Norephedrine hydrochloride 99+% 100 GR 371元
  • Acros Organics:盐酸DL-降麻黄碱 DL-Norephedrinehydrochloride,99+%(154-41-6)
  • 溶于水和醇，不溶于醚、氯仿和苯。
  • MSDS 信息:(+/-)-Phenylpropanolamine hydrochloride(154-41-6).msds
  • 用途一:本品为鼻减充血剂，减食欲剂。
  • MOL 文件:154-41-6.mol
  • 上游原料:亚硫酸氢钠 --> 硝基乙烷 --> 苛性苏打
  • Sigma Aldrich:154-41-6(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. N - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Chemical Classification - Nutrition Research
  4. Alkaloid - Phytochemicals by Chemical Classification
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Alkaloids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals Found in Plants
  4. Aliphatic Compounds 脂肪烃化合物
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Nutrition Research
  4. Biochemicals Found in Plants
  5. Aliphatic Compounds 脂肪烃化合物
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Pathways
  5. Metabolites and Cofactors on the Metabolic Pathways Chart
  6. Cholesterol

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