Thimerosal 硫柳汞钠

CAS 54-64-8 MFCD00013062

化学结构图

54-64-8
SMILES: [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O

化学属性

Mol. FormulaC9H9HgNaO2S
Mol. Weight405
Melting Point232-233
Solubility1 G/ML (20 ºC)
Stability对光敏感
Flash Point250 °C
Appearance 为乳白至微黄色结晶性粉末;稍有特殊臭,微有引湿性。遇光易变质。1%水溶液pH6—8。易溶于水、乙醇,不溶于乙醚和苯。

别名和识别编码

Chemical NameThimerosal
Synonym Elicide 乙汞硫水杨酸钠盐 2-(ETHYLMERCURIOMERCAPTO)BENZONIC ACID SODIUM SALT ((o-carboxyphenyl)thio)ethylmercurysodiumsalt MERTHIOLA 乙基噻吩酸钠盐/硫柳汞钠/硫柳汞 Mercurothiolate Thiomersalate 硫柳汞钠 Merzonin Merfamin Merthiolate sodium; Ethylmercurithiosalicylic acid sodium salt THIOMERSAL Mercury, ethyl(2-mercaptobenzoate-S)-, sodium salt ETHYL[SOD 硫柳汞,硫柳汞酸钠,乙汞硫水杨酸钠盐;Mercury-([o-carboxyphenyl]thio)ethyl钠盐;乙基噻吩酸钠盐;乙汞硫柳酸钠 SODIUM ETHYLMERCURITHIOSALICYLATE MERTHIOLATE THIMEROSAL SOLUTION 硫柳汞酸钠 Ethyl (sodium o-mercaptobenzoato)mercury MERCURY-[(O-CARBOXYPHENYL)THIO]ETHYL SODIUM SALT Merzonin sodium Thimerosal 硫柳汞,硫柳汞酸钠,乙 ((o-carboxyphenyl)thio)ethyl-mercursodiumsalt Mercury-([o-carboxyphenyl]thio)ethyl 钠盐 乙基噻吩酸 钠盐 乙汞硫柳酸钠 乙汞硫水杨酸 钠盐 ETHYLMERCURITHIOSALICYLIC ACID SODIUM SALT 乙汞硫水杨酸钠盐/硫柳汞钠 o-(Ethylmercurithio)benzoic acid sodium salt Sodium ethylmercuric ETHYL MERCURITHIOSALICYLIC ACID NA Ethyl(2-mercaptobenzoato-S)mercury sodium salt Ethylmerkurit ((o-Carboxyphenyl)thio)ethylmercury sodium salt Sodium merthiolate Mercurate(1-), ethyl(2-mercaptobenzoate(2-)-O,S)-, sodium salt {Chem Ethylmercurithiosalicylic acid sodium salt Mertorgan Merthiolate sodium 乙汞硫柳酸鈉 Thiomersal 硫柳汞; 硫柳汞酸钠; 乙汞硫水杨酸钠盐; Mercury-([o-carboxyphenyl]thio)ethyl钠盐;乙基噻吩酸钠盐; 乙汞硫柳酸钠 ethyl(2-mercaptobenzoate(2-)-o,s)-mercurate(1-sodiumsalt 2-(ETHYLMERCURIOMERCAPTO)BENZOIC ACID SODIUM SALT Sodium
CAS Number54-64-8
PubChem Substance ID24900257
EC Number200-210-4
Beilstein Registry Number8169555
MDL NumberMFCD00013062
Chemical Name Translation硫柳汞钠
Merck Number13,9389
Wiswesser Line NotationQVR BS-HG-2 &-NA-
LabNetwork Molecule IDLN01111949
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分类

  • Analytical Standards, Analytical/Chromatography, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application, Bactericides, Chromatography, Environmental Standards, Pesticides, Pesticides & Metabolites, Preservatives and Disinfectants
  • {SNA} Analytical Reagents, Analytical/Chromatography, Antibiotics,
  • {SNA} Analytical Standards,
  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards S - T, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • {SA} Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application,
  • {SNA} Analytical Standards,

产品应用

  • 是一种有效的消毒剂,可用于皮肤、黏膜的消毒,也用于药剂的防腐。制剂有酊剂,霜剂。

相关文献及参考

  • Merck:13,9389 Beilstein: 10,IV,272

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H330 Fatal if inhaled 吸入致命
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H310 Fatal in contact with skin 皮肤接触致命
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H300 Fatal if swallowed 吞食致命
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes 6.1 T+,N T+,N,T
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P302+P350
  • P304+P340
Signal word Danger
RTECSOV8400000
Safety Statements
  • S13 Keep away from food, drink and animal foodstuffs 远离食品、饮料和动物饲料保存;
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
Risk Statements
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有剧毒
  • R33 Danger of cumulative effects 有累积作用的危险
  • R50/53
UN Number 2025
Packing GroupIII
Storage condition 密封避光保存 Store at RT.
Hazard Class6.1(b)
Warnings 危化品目录(2015) 危险化学品
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 104 mg/kg/1Y-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Reproductive - Tumorigenic effects - uterine tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 4,185,1971

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TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 83 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Lungs, Thorax, or Respiration - other changes
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   JTCTDW Journal of Toxicology, Clinical Toxicology.  (Marcel Dekker, 270
   Madison Ave., New York, NY 10016)  V.19-    1982-  Volume(issue)/page/year:
   34,453,1996

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
   New York, Inc., 1971  Volume(issue)/page/year: -,290,1971

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCOC** Pesticide Chemicals Official Compendium, Association of the American
   Pesticide Control Officials, Inc., 1966.  (Topeka, KS)
   Volume(issue)/page/year: -,1130,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 98 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 4,185,1971

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 45 mg/kg
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   20,106,1992

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 900 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 287,47,1993

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 450 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 287,47,1993

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 45 mg/kg
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York,

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 9 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 287,57,1993

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 125 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 287,71,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Ocular
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 65 ug/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   RIGAA3 Rinsho Ganka.  Clinical Ophthalmology.  (Igaku Shoin, 5-24-3 Hongo,
   Bunkyo-ku, Tokyo 113-91, Japan)  V.1-    1947-  Volume(issue)/page/year:
   26,631,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1300 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   AROPAW Archives of Ophthalmology (Chicago).  (AMA, 535 N. Dearborn St.,
   Chicago, IL 60610)  New series: V.1-44(3), 1929-50; V.64-    1960-
   Volume(issue)/page/year: 93,52,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Ocular
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 112 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   AROPAW Archives of Ophthalmology (Chicago).  (AMA, 535 N. Dearborn St.,
   Chicago, IL 60610)  New series: V.1-44(3), 1929-50; V.64-    1960-
   Volume(issue)/page/year: 93,52,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 130 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive -

其他信息

  • 职业标准:TWA 0.01 毫克 (汞)/立方米; STEL 0.03 毫克 (汞)/立方米
  • 上游原料:溴乙烷
  • Acros Organics:乙汞硫水杨酸钠盐/硫柳汞钠 Ethylmercurithiosalicylic acid, sodium salt, 97.0-101.0%(54-64-8)
  • 类别:农药
  • 毒性分级:高毒
  • 用途二:是一种有效的消毒剂,可用于皮肤、黏膜的消毒,也用于药剂的防腐。制剂有酊剂,霜剂。
  • F:8
  • 灭火剂:水, 二氧化碳, 干粉, 砂土
  • 可燃性危险特性:可燃, 火场排出含汞, 氮氧化物, 硫氧化物, 氧化钠辛辣刺激烟雾
  • 图谱信息:硫柳汞钠(54-64-8)红外图谱(IR2) 硫柳汞钠(54-64-8)红外图谱(IR1) 硫柳汞钠(54-64-8)核磁图( 13 CNMR)
  • 储运特性:库房低温, 通风, 干燥; 与食品原料分开存放
  • 有臭味,微有引湿性,遇光易变质。易溶于水、乙醇,不溶于乙醚及苯,在空气中稳定。
  • 急性毒性:口服- 大鼠 LD50 75 毫克/ 公斤; 口服- 小鼠 LD50: 81 毫克/公斤
  • 用途一:是一种有效的消毒剂,可用于皮肤、黏膜的消毒,也用于药剂的防腐。
  • 硫柳汞钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 10013914 硫柳汞钠 25g 130元 2011/08/23 10013916 硫柳汞钠 100g 498元 2011/08/23 10013924 硫柳汞钠 25g 128.7元
  • Sigma Aldrich:54-64-8(sigmaaldrich)
  • MOL 文件:54-64-8.mol

系列性分类


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