1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione hemiethane-1,2-diamine salt 1,3-二甲基-3,7-二氢-1H-嘌呤-2,6-二酮-1,2-乙二胺盐(2:1)
CAS 317-34-0 MFCD00013221
化学结构图
SMILES: Cn1c(=O)c2[nH]cnc2n(C)c1=O.Cn1c(=O)c2[nH]cnc2n(C)c1=O.NCCN
化学属性
| Mol. Formula | C16H24N10O4 |
|---|---|
| Mol. Weight | 420 |
| Appearance | 白色或淡黄色颗粒或粉末。熔点269-274℃。易溶于水，不溶于乙醇或乙醚。露置空气中逐渐吸收二氧化碳气体而分解或茶碱。微有近臭，味苦。 powder |
| Solubility | H2O: 3.7 mg/mL solutions should be freshly prepared. |
| Melting Point | 269-270°C |
| Density | 1.514 |
别名和识别编码
| Chemical Name | 1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione hemiethane-1,2-diamine salt |
|---|---|
| Synonym | Aminophylline dihydrochloride hyderate 1h-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-,compd.with1,2-ethanediamine( aminocadol 茶碱胺 carena aminophyllin 氨茶碱 (Theophylline)2 · Ethylenediamine 茶碱乙烯二胺 (Theophylline)2 · Ethylenediamine 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, cmpd. with 1,2-ethanediamine (2:1) Theophylline hemi(ethylenediamine) complex Theophylline hemiethylenediamine complex 3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dionecompd.with1,2-ethanediamine(2 cardophyllin 1h-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-,compdwith1,2-ethanediamine(2 cariomin aminodur cardiomin 无水氨茶硷 Amminofillina cardiofilina THEOPHYLLINE ETHYLENEDIAMINE THEOPHYLLINE COMPOUND WITH ETHYLENEDIAMINE AMINOPHYLLINE cardophylin Theophylline hemi(ethylenediamine) complex 1h-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-,compd.with1,2-ethanediamine 乙二胺茶碱 ammophyllin 1,3-二甲基-3,7-二氢-1H-嘌呤-2,6-二酮-1,2-乙二胺盐 aminofilina 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, cmpd. with 1,2-ethanediamine (2:1) Theophylline hemiethylenediamine complex aminocardol 氨茶碱，水合 |
| CAS Number | 317-34-0 |
| PubChem Substance ID | 9433 |
| EC Number | 206-264-5 |
| MDL Number | MFCD00013221 |
| Chemical Name Translation | 1,3-二甲基-3,7-二氢-1H-嘌呤-2,6-二酮-1,2-乙二胺盐(2:1) |
| Merck Number | 465 |
| Reaxys-RN | 5783720 |
| LabNetwork Molecule ID | LN01740182 |
| InChI | InChI=1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2 |
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信息真实价格透明
资金保障
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分类
- {SNA} A-AM, Bioactive Small Molecule Alphabetical Index, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Phosphodiesterase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- A-AM, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Phosphodiesterase Inhibitors
- {SNA} A-AM, Bioactive Small Molecules, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Phosphodiesterase Inhibitors, 细胞生物学
- {SNA} A-AM, Bioactive Small Molecules, Cell Biology,
产品应用
- 非选择性磷酸酯酶抑制剂（phosphodiesterase ，PDE），抗癫痫药。
相关文献及参考
- [2]. E Tai, et al. Response of blood gas tensions to aminophylline and isoprenaline in patients with asthma. Thorax. 1967 Nov;22(6):543-9.
- [3]. Daly JW, et al. Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63.
- Chanda, et al., Antiepileptic drugs and methylxanthines: clinical significance. Pol. J. Pharmacol. 50 , 80-82, (1998) 摘要
- Merck: 14,465
- Thakker, et al. Analytical Profiles of Drug Substances 2nd ed.,, (1982) 2 , 1-44
- [1]. Ming-Chih Yu, et al. Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/keta
- [1]. Ming-Chih Yu, et al. Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia. ur J Pharmacol. 2010 Feb 10;627(1-3):269-75.
安全信息
GHS Symbol
- H301 Toxic if swallowed 吞食有毒
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P310
- P301+P310+P330
- P302+P350
- P302+P352+P333+P313+P362+P364
- P308+P311
- P308+P313
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- R34 Causes burns 会导致灼伤
- R42/43
- R22 Harmful if swallowed 吞咽有害
其他信息
- 上游原料:茶碱 --> 混合机
- 方法一:本品为茶碱与乙二胺的复盐。将茶碱投入混合机，搅拌冷却，用压缩空气喷入新蒸馏过的乙二胺和蒸馏水的混和液，喷毕，继续搅拌10分钟，得氨茶碱。
- 用途一:主要用于支气管哮喘和哮喘型慢性支气管炎，也可用于急性心功能不全、心脏性哮喘及胆绞痛等
- 易溶于水，不溶于乙醇或乙醚,露置空气中逐渐吸收二氧化碳气体而分解或茶碱,微有近臭，味苦。
- 用途二:本品作用、用途与茶碱相同。分子中乙二胺在存在增强了扩张支气管和冠状血管作用。
- MSDS 信息:Theophylline-ethylenediamine-addition compound (2:1)(317-34-0).msds
- F:10-23
- color:white to off-white
- 用途三:非选择性磷酸酯酶抑制剂（phosphodiesterase ，PDE），抗癫痫药。
- MOL 文件:317-34-0.mol
- Sigma Aldrich:317-34-0(sigmaaldrich)
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