Coptisine 盐酸黄连碱
CAS 6020-18-4 MFCD00016676
化学结构图
SMILES: [Cl-].c1c2c(cc3c1OCO3)-c1cc3ccc4c(c3c[n+]1CC2)OCO4
化学属性
| Mol. Formula | C19H14ClNO4 |
|---|---|
| Mol. Weight | 356 |
| Melting Point | >258 |
别名和识别编码
| Chemical Name | Coptisine |
|---|---|
| CAS Number | 6020-18-4 |
| Synonym | 6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium Chloride 7,8,13,13a-Tetradehydro-2,3:9,10-bis(methylenedioxy)berbinium chloride Bis(methylenedioxy)protoberberine chloride 黄连碱 |
| Chemical Name Translation | 盐酸黄连碱 |
| InChIKey | LUXPUVKJHVUJAV-UHFFFAOYSA-M |
| LabNetwork Molecule ID | LN01262692 |
| MDL Number |
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分类
- Amines
- Heterocycles
- Inhibitor
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- 抗菌。 氯化黄连碱, 黄连碱, 6020-18-4
相关文献及参考
- [2]. He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94.
- [3]. Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565.
- [4]. Zhou X, et al. Inhibition activity of a traditional Chinese herbal formula Huang-Lian-Jie-Du-Tang and its major components found in its plasma profile on neuraminidase-1. Sci Rep. 2017 Nov 14;7(1):15549.
- Blaney, W., et al.: Physiol. Entomol., 12, 281 (1987),
- Sethi, M., et al.: J. Pharm. Sci., 72, 538 (1983),
- Yahara, S., et al.: Chem. Pharm. Bull., 33, 527 (1985),
- [1]. Yu D, et al. The IDO inhibitor copti
- [1]. Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302.
安全信息
GHS Symbol
其他信息
- 极略微溶于水, 微溶于乙醇, 溶于碱。
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