Acacetin 5,7-二羟基-2-(4-甲氧基苯基)-4H-1-苯并吡喃-4-酮

CAS 480-44-4 MFCD00016936

化学结构图

480-44-4
SMILES: COC1=CC=C(C=C1)C1=CC(=O)C2=C(C=C(O)C=C2O)O1

化学属性

Mol. FormulaC16H12O5
Mol. Weight284.26
Melting Point260-265 °C
Boiling Point518.6 °C at 760 mmHg

别名和识别编码

Chemical NameAcacetin
CAS Number480-44-4
Synonym Acacetin {LY} Acacetin {} {LY} Acacetin {} {} {LY} Acacetin {} {} {} {LY} Acacetin {} {} {} {} {LY} Acacetin {} {} {} {} {} {LY} Acacetin {} {} {} {} {} {} {LY} Acacetin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acacetin {} {} {} {} {} {} {} {} {LY} Acacetin {} {} {} {} {} {} {} {} {} {LY} Acacetin {} {} {} {} {} {} {} {} {} {} {LY} Acacetin {} {} {} {} {} {} {} {} {} {} {} {LY} Acacetin {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acacetin {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acacetin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acacetin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acacetin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acacetin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acacetin {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00016936
Beilstein Registry Number277879
EC Number207-552-3
PubChem Substance ID354334663
Chemical Name Translation5,7-二羟基-2-(4-甲氧基苯基)-4H-1-苯并吡喃-4-酮
Merck Number13
Wiswesser Line NotationT66 BO EVJ CR DO1& GQ IQ
LabNetwork Molecule IDLN01276215
Reaxys-RN277879
Canonical SMILESO=C1C=C(C2=CC=C(OC)C=C2)OC3=CC(O)=CC(O)=C13
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分类

  • {SNA} Antioxidant, Antioxidants and Cytoprotectants, Cell Signaling and Neuroscience, Cell Stress, Functional Foods, Ginkgo
  • {SNA} Antioxidant, Functional Foods, Ginkgo biloba, Phytochemicals by Plant (Food/Spice/Herb), 一氧化氮和细胞应激, 抗氧化剂和细胞保护剂, 细胞信号转导和神经科学, 细胞应激, 细胞生物学, 营养研究
  • Heterocycles
  • Miscellaneous Reagents
  • {SNA} Antioxidant, Antioxidants and Cytoprotectants, Cell Stress, Functional Foods, Ginkgo biloba, Nitric Oxide and Cell Stress, Phytochemicals by Plant (Food/Spice/Herb), 细胞信号转导和神经科学,

产品应用

  • VEGF expression inhibitor and tumor angiogenesis. A flavonoid with antiaggregatory activity in human blood.

相关文献及参考

  • Liu, L. et al.: Biochem. Bioph. Res. Co. 413, 299 (2011); Bojic, M. et al.: Nutrition J. 10, 73 (2011)

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSDJ3002000
Signal word
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 933 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 32,210,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 933 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 32,210,1969

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,401,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 mg/kg
SEX/DURATION            : female 1 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 42,467,1990

其他信息

  • F:3-8-10
  • Sigma Aldrich:480-44-4(sigmaaldrich)
  • MOL 文件:480-44-4.mol

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Ginkgo biloba - Phytochemicals by Plant (Food/Spice/Herb)
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Food & Beverage Standards - Chromatography
  5. Food Residue Analysis - Food & Beverage Standards

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