N-Cbz-L-Phenylalanine N-苄氧羰基-L-苯丙氨酸

CAS 1161-13-3 MFCD00020418

化学结构图

1161-13-3
SMILES: O=C(N[C@@H](Cc1ccccc1)C(=O)O)OCc1ccccc1

化学属性

Mol. FormulaC17H17NO4
Mol. Weight299.32
Melting Point85-87°C
TSCANo
Density1.248
Appearance 白色结晶。熔点85-88℃。
Refractive index5.3 ° (C=4, AcOH)
Boiling Point511.5°C at 760 mmHg

别名和识别编码

Chemical NameN-Cbz-L-Phenylalanine
Synonym Z-Phe-OH {LY} Z-Phe-OH {} {LY} Z-Phe-OH {} {} {LY} Z-Phe-OH {} {} {} {LY} Z-Phe-OH {} {} {} {} {LY} Z-Phe-OH {} {} {} {} {} {LY} Z-Phe-OH {} {} {} {} {} {} {LY} Z-Phe-OH {} {} {} {} {} {} {} {LY} Z-Phe-OH {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Z-Phe-OH {} {} {} {} {} {} {} {} {} {LY} Z-Phe-OH {} {} {} {} {} {} {} {} {} {} {LY} Z-Phe-OH {} {} {} {} {} {} {} {} {} {} {} {LY} Z-Phe-OH {} {} {} {} {} {} {} {} {} {} {} {} {LY} Z-Phe-OH {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Z-Phe-OH {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Z-Phe-OH {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Z-Phe-OH {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Z-Phe-OH {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Z-Phe-OH {} {} {} {} {} {} {} {} {} {} {} {}
Beilstein Registry Number2222826
PubChem Substance ID70878
CAS Number1161-13-3
EC Number214-599-3
MDL NumberMFCD00020418
Reaxys-RN2222826
Chemical Name TranslationN-苄氧羰基-L-苯丙氨酸
InChIKeyRRONHWAVOYADJL-HNNXBMFYSA-N
LabNetwork Molecule IDLN00009398
InChIInChI=1S/C17H17NO4/c19-16(20)15(11-13-7-3-1-4-8-13)18-17(21)22-12-14-9-5-2-6-10-14/h1-10,15H,11-12H2,(H,18,21)(H,19,20)/t15-/m0/s1
Canonical SMILESO=C([C@H](CC1=CC=CC=C1)NC(OCC2=CC=CC=C2)=O)O
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分类

  • {SNA} Amino Acid Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Phenylalanine
  • {SA} Amino Acid Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Phenylalanine
  • {SNA} Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Phenylalanine

产品应用

  • 用于生化试剂，雷米普利，增压素等多肽合成。

相关文献及参考

  • Beilstein: 14,IV,1596

安全信息

WGK Germany3
RTECSAY4343000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Signal word Warning
GHS Symbol
Safety Statements
Risk Statements
  • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
Storage condition 2-8°C {LY} 2-8°C Store at RT. Store at room temperature {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 251 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 67,1726,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 68,696,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 280 mg/kg
SEX/DURATION            : female 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 68,696,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 280 mg/kg
SEX/DURATION            : female 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 68,696,1979

其他信息

  • 用途二:用于生化试剂，雷米普利，增压素等多肽合成。
  • 类别:有毒物质
  • 毒性分级:中毒
  • 储运特性:库房低温通风干燥
  • Sigma Aldrich:1161-13-3(sigmaaldrich)
  • 可燃性危险特性:热分解排出有毒氮氧化物烟雾
  • N-苄氧羰基-L-苯丙氨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xp620056 N-苄氧羰基-L-苯丙氨酸 100g 3500元 2011/04/16 C0660 N-苄氧羰基-L-苯丙氨酸 N-Carbobenzoxy-L-phenylalanine 5G 239元 2011/04/16 C0660 N-苄氧羰基-L-苯丙氨酸 N-Carbobenzoxy-L-phenylalanine 25G 727元
  • MOL 文件:1161-13-3.mol
  • 比旋光度:5 ° (c=5,acetic acid)
  • 图谱信息:N-苄氧羰基-L-苯丙氨酸(1161-13-3)Raman光谱 N-苄氧羰基-L-苯丙氨酸(1161-13-3)红外图谱(IR2) N-苄氧羰基-L-苯丙氨酸(1161-13-3)质谱(MS) N-苄氧羰基-L-苯丙氨酸(1161-13-3)核磁图( 1 HNMR) N-苄氧羰基-L-苯丙氨酸(1161-13-3)红外图谱(IR1)
  • MSDS 信息:Z-Phe-OH(1161-13-3).msds
  • 用途一:用于蛋白质及多肽等的合成中，广泛应用于医药、生物化学、食品、化妆品等多种产品合成中
  • 灭火剂:水, 二氧化碳, 干粉, 泡沫
  • Alfa Aesar:N-苄氧羰基-L-苯基丙氨酸,99% N-Benzyloxycarbonyl-L-phenylalanine, 99%(1161-13-3)
  • 急性毒性:叶鞘-小鼠 LD50: 250 毫克/公斤
  • Acros Organics:N-羰苄氧基-L-苯丙氨酸 N-Carbobenzyloxy-L-phenylalanine, 99+%(1161-13-3)
  • TCI Shanghai:N-苄氧羰基-L-苯基丙氨酸 N-Carbobenzoxy-L-phenylalanine,>;98.0%(LC)(T)(1161-13-3)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Amino Acid Derivatives 氨基酸及其衍生物
  5. Phenylalanine - Amino Acid Derivatives
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Amino Acid Derivatives 氨基酸及其衍生物
  5. Phenylalanine - Amino Acid Derivatives
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Amino Acids 氨基酸
  4. Modified Amino Acids - Amino Acids
  5. Cbz-amino Acids
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Protected & Labeled Amino Acids

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