5-Fluoroisatin 5-氟靛红

CAS 443-69-6 MFCD00022795

化学结构图

443-69-6
SMILES: O=C1Nc2ccc(F)cc2C1=O

化学属性

Mol. FormulaC8H4FNO2
Mol. Weight165.12
Melting Point224-227°C
TSCANo

别名和识别编码

Chemical Name5-Fluoroisatin
CAS Number443-69-6
Alfabeta NameFLUOROISATIN 5-
MDL NumberMFCD00022795
Synonym 5-Fluoroisatin {LY} 5-Fluoroisatin {} {LY} 5-Fluoroisatin {} {} {LY} 5-Fluoroisatin {} {} {} {LY} 5-Fluoroisatin {} {} {} {} {LY} 5-Fluoroisatin {} {} {} {} {} {LY} 5-Fluoroisatin {} {} {} {} {} {} {LY} 5-Fluoroisatin {} {} {} {} {} {} {} {LY} 5-Fluoroisatin {} {} {} {} {} {} {} {} {LY} 5-Fluoroisatin {} {} {} {} {} {} {} {} {} {LY} 5-Fluoroisatin {} {} {} {} {} {} {} {} {} {} {LY} 5-Fluoroisatin {} {} {} {} {} {} {} {} {} {} {} {LY} 5-Fluoroisatin {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5-Fluoroisatin {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5-Fluoroisatin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5-Fluoroisatin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5-Fluoroisatin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5-Fluoroisatin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5-Flu
PubChem Substance ID87559306
EC Number000-000-0
Beilstein Registry Number21(3/4)5004
Chemical Name Translation5-氟靛红
Reaxys-RN131241
LabNetwork Molecule IDLN00007468
InChIInChI=1S/C8H4FNO2/c9-4-1-2-6-5(3-4)7(11)8(12)10-6/h1-3H,(H,10,11,12)
Canonical SMILESC1=C(F)C=CC2=C1C(C(=O)N2)=O
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分类

  • Building Blocks, C7 to C9, Chemical Synthesis, Fluorinated Building Blocks, Heterocyclic Building Blocks, Heterocyclic Fluorinated Building Blocks, Indoles, Indolines, Other Fluorinated Heterocycles
  • {SNA} Building Blocks, C7 to C9, Chemical Synthesis, Fluorinated Building Blocks, Heterocyclic Building Blocks, Heterocyclic Fluorinated Building Blocks, Indoles, Indolines, Other Fluorinated Heterocycles

产品应用

  • It showed antibacterial and antifungal activities.

相关文献及参考

  • He, X., et al.: Nature, 374, 617 (1995),
  • Summers, S., et al.: J. Biol. Chem., 274, 17934 (1999),
  • 1. Dandia, A.; et al., Versatile three component procedure for combinatorial synthesis of biologically relevant scaffold spiro[indole-thiazolidinones] under aqueous conditions Green Chem. 13 , 1852, (2011)
  • 2. Aboul-Fadl, T.; et al., Microwave-assisted solution-phase synthesis and DART-mass spectrometric monitoring of a combinatorial library of indolin-2,3-dione Schiff bases with potential antimycobacterial activity Molecules 16 , 5194, (2011) 摘要
  • 3. Liang, Z.; et al., Identification and synthesis of N'-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase Bioorg. Med. Chem. Lett. 21 , 3749, (2011)
  • 4. Lockman, J. W.; et al., Oxindole derivatives as inhibitors of TAK1 kinase Bioorg. Med. Chem. Lett. 21 , 1724, (2011) 摘要
  • 5. Kang, I.-J.; et al., Isatin-ß-thiosemicarbazones as potent herpes simplex virus inhibitors Bioorg. Med. Chem. Lett. 21 , 1948, (2011)
  • 6. Cushing, T. D.; et al., A novel series of IKKß inhibitors part I: Initial SAR studies of a HTS hit Bioorg. Med. Chem. Lett. 21 , 417, (2011)
  • 7. Abdel-Rahman, R. M.; et al., Synthesis of fluorine heterocyclic nitrogen systems derived from sulfa drugs as photochemical probe agents for inhibition of vitiligo disease - part II E-J. Chem. 7 , s93, (2010)
  • 8. Banerjee, D.; et al., Novel isatinyl thiosemicarbazones derivatives as potential molecule to combat HIV-TB co-infection Eur. J. Med. Chem. 46 , 106, (2010) 摘要
  • Beil. 21 ,IV,5004
  • FT-NMR 1 (2), 1439:C / RegBook 1 (2), 2059:B / Structure Index 1 , 327:C:4

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
Signal word
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S37 Wear suitable gloves 戴适当手套;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C {LY} 2-8°C Store at room temperature {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°

其他信息

  • 5-氟靛红价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 F0589 5-氟靛红 5-Fluoroisatin 5G 597元 2014/06/02 F0589 5-氟靛红 5-Fluoroisatin 25G 1810元 2010/06/21 367700050 5-氟靛红 5-Fluoroisatin 98% 5 GR 719元
  • Sigma Aldrich:443-69-6(sigmaaldrich)
  • MOL 文件:443-69-6.mol
  • 下游产品:氟马西尼
  • TCI Shanghai:5-氟靛红 5-Fluoroisatin,>;98.0%(GC)(T)(443-69-6)
  • Alfa Aesar:5-氟靛红,98% 5-Fluoroisatin, 98%(443-69-6)
  • Hazard Note:Irritant
  • 图谱信息:5-氟靛红(443-69-6)红外图谱(IR1) 5-氟靛红(443-69-6)质谱(MS)
  • Acros Organics:5-氟靛红 5-Fluoroisatin, 98%(443-69-6)
  • 用途一:用作心脑血管、抗炎杀菌药等中间体

系列性分类


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