2-(6-Methoxynaphthalen-2-yl)acetic acid 2-(6-甲氧基萘-2-基)乙酸

CAS 23981-47-7 MFCD00033105

化学结构图

23981-47-7
SMILES: COC1C=C2C=CC(CC(O)=O)=CC2=CC=1

化学属性

Mol. FormulaC13H12O3
Mol. Weight216
Melting Point176-177 ºC
Density1.235

别名和识别编码

Chemical Name2-(6-Methoxynaphthalen-2-yl)acetic acid
CAS Number23981-47-7
Synonym 2-(6-Methoxy-2-naphthyl)acetic Acid 2-(6-Methoxy-2-naphthyl)acetic acid; 6-Methoxy-2-naphthylacetic acid; BRL 10720 6-MNA 6-Methoxy-2-naphthaleneacetic acid 6-Methoxy-2-naphthylacetic Acid 6-Metossi-2-naphtil acetico 6-methoxy-2-naphthylacetic acid BRL 10720 Desmethyl Naproxen
EC Number245-967-1
MDL NumberMFCD00033105
Chemical Name Translation2-(6-甲氧基萘-2-基)乙酸
Wiswesser Line NotationL66J CO1 H1VQ
Beilstein Registry Number2371586
PubChem Substance ID329789056
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分类

  • Metabolites & Impurities,
  • {SNA} Building Blocks, C13, Chemical Synthesis, Ethers, Organic Building Blocks, Oxygen Compounds
  • Aromatics
  • Inhibitors

产品应用

  • A metabolite of Nabumetone. A competitive, non-selective COX inhibitor.

相关文献及参考

  • Turpeinen et. al.: Drug Metabolism and Dispositoin, 37: 1017 (2009); Daniels, F., et al.: J. Invest. Dermatol., 44, 259

安全信息

RTECSQJ1045000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 120 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   119,600,1980

GHS Symbol
WGK Germany3
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Signal word Danger
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置；
Hazard Codes Xn,Xi,N
Risk Statements
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R50 Very toxic to aquatic organisms 对水生生物极毒
  • R22 Harmful if swallowed 吞咽有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Ethers - Oxygen Compounds
  6. C15 to C19 - Ethers

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