5H-Cyclopropa(3,4)benz(1,2-e)azulen-5-one,1,1a-alpha,16-beta,4,4a,7a-alpha,7b,8,9,9a-decahydro-4a-beta,7b-alpha,9-beta,9a-alpha-tetrahydroxy-3-(hydroxymethyl)- 1,1,6,8-alpha- tetramethyl-,9,9a-diacetate, (+)

CAS 24928-15-2 MFCD00036735

化学结构图

24928-15-2
SMILES: CC1(C)[C@H]2[C@@H]3C=C(C[C@@]4(O)[C@@H](C=C(C)C4=O)[C@@]3(O)[C@H](C)[C@@H](OC(C)=O)[C@@]12OC(C)=O)CO

化学属性

Mol. FormulaC24H32O8
Mol. Weight448.51

别名和识别编码

Chemical NamePhorbol 12,13-diacetate
Synonym PDA Phorbol 12,13-diacetate Phorbol-12,13-diacetate
MDL NumberMFCD00036735
Beilstein Registry Number2317312
PubChem Substance ID24899011
Wiswesser Line NotationL E3 B675 MV IU NUTJ BQ C1 DOV1 EOV1 F1 F1 J1Q LQ N1
CAS Number24928-15-2
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品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, P, Protein Kinase Activators, Protein Kinase C (PKC), Serine/Threonine Kinase Activators, Serine/Threonine Kinase Biology
  • {SNA} Kinase/Phosphatase Biology, Protein Kinase Activators, Protein Kinase C (PKC), Serine/Threonine Kinase Activators, Serine/Threonine Kinase Biology, 细胞信号转导和神经科学, 细胞生物学

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P302+P350
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H330 Fatal if inhaled 吸入致命
  • H310 Fatal in contact with skin 皮肤接触致命
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H300 Fatal if swallowed 吞食致命
  • H319 Causes serious eye irritation 严重刺激眼睛
RTECSGZ0651000
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Hazard Codes T+
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有剧毒
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 19 mg/kg/32W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   31,1074,1971

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 200 ug/tube
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   33,3103,1973

系列性分类


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