5-Fluorouridine 5-氟尿嘧啶核苷

CAS 316-46-1 MFCD00036832

化学结构图

316-46-1
SMILES: O=c1[nH]c(=O)n([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1F

化学属性

Mol. FormulaC9H11FN2O6
Mol. Weight262.19
Melting Point182-184°C
Solubilitysoluble
Refractive index18 ° (C=1, H2O)

别名和识别编码

Chemical Name5-Fluorouridine
MDL NumberMFCD00036832
CAS Number316-46-1
Synonym 5-Fluorouridine {LY} 5-Fluorouridine {} {LY} 5-Fluorouridine {} {} {LY} 5-Fluorouridine {} {} {} {LY} 5-Fluorouridine {} {} {} {} {LY} 5-Fluorouridine {} {} {} {} {} {LY} 5-Fluorouridine {} {} {} {} {} {} {LY} 5-Fluorouridine {} {} {} {} {} {} {} {LY} 5-Fluorouridine {} {} {} {} {} {} {} {} {LY} 5-Fluorouridine {} {} {} {} {} {} {} {} {} {LY} 5-Fluorouridine {} {} {} {} {} {} {} {} {} {} {LY} 5-Fluorouridine {} {} {} {} {} {} {} {} {} {} {} {LY} 5-Fluorouridine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5-Fluorouridine {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5-Fluorouridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5-Fluorouridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5-Fluorouridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5-Fluorouridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5-Fluorouridine {} {} {} {} {} {} {} {} {} {
Beilstein Registry Number24(3/4)1231
EC Number206-260-3
PubChem Substance ID87559881
Reaxys-RN33662
Chemical Name Translation5-氟尿嘧啶核苷
Wiswesser Line NotationT6NVMVJ EF A- ET5OTJ B1Q CQ DQ
InChIInChI=1S/C9H11FN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1
LabNetwork Molecule IDLN00189898
Canonical SMILESOC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(C(F)=C2)=O)=O)O1
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分类

  • {SNA} Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides
  • {SNA} Nucleoside Analogs, 核苷,核苷酸和寡核苷酸, 生化试剂

安全信息

WGK Germany3
RTECSYU8050000
Personal Protective Equipment Eyeshields, Gloves
Hazard Codes Xn
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S22 Do not breathe dust 不要吸入粉尘;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
Risk Statements
Signal word
Hazard statements
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P308+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P405 Store locked up. 上锁保管。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
Storage condition 2-8°C, stored under nitrogen {LY} 2-8°C, stored under nitrogen {} {LY} 2-8°C, stored under nitrogen {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 384 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 97,470,1958

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 97,470,1958

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ADTEAS Advances in Teratology.  (New York, NY)  V.1-5, 1966-72.
   Discontinued.  Volume(issue)/page/year: 3,181,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 900 nmol/L
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 49,2551,1984

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 10 umol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   14,205,1965

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 ug/L
REFERENCE :
   HEREAY Hereditas (Lund, Sweden).  (Gjoerloffsgatan 121, S-261 34 Landskrona,
   Sweden)  V.1-    1947-  Volume(issue)/page/year: 88,127,1978

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 20 mg/L
REFERENCE :
   VIRLAX Virology.  (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
   V.1-    1955-  Volume(issue)/page/year: 74,154,1976

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 500 umol/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,2406,1979

其他信息

  • 比旋光度:17 ° (c=2, water 25 °C)
  • 图谱信息:5-氟尿嘧啶核苷(316-46-1)红外图谱(IR1) 5-氟尿嘧啶核苷(316-46-1)质谱(MS) 5-氟尿嘧啶核苷(316-46-1)红外图谱(IR2)
  • TCI Shanghai:5-氟尿嘧啶核苷 5-Fluorouridine,>;98.0%(T)(316-46-1)
  • Sigma Aldrich:316-46-1(sigmaaldrich)
  • Hazard Note:Harmful
  • MSDS 信息:5-Fluorouracil-1beta-D-ribofuranoside(316-46-1).msds
  • 用途一:用于抗肿瘤药物DFUR和FUDR生产的中间体、基因工程和生化试剂等
  • 5-氟尿嘧啶核苷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 F0636 5-氟尿嘧啶核苷 5-Fluorouridine 5G 2010元 2014/06/02 F0636 5-氟尿嘧啶核苷 5-Fluorouridine 1G 762元 2010/06/21 258332500 5-氟尿嘧啶核苷 5-Fluorouridine 99+% 250 MG 1317元
  • F:10
  • MOL 文件:316-46-1.mol
  • Acros Organics:5-Fluorouridine, 99+%(316-46-1)
  • 用途二:用于抗肿瘤药物DFUR和FUDR生产的中间体、基因工程和生化试剂等。
  • 外观性质:白色结晶粉末。熔点:180-183℃

系列性分类


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