3-Amino-2,3-dihydrobenzoic acid hydrochloride 3-氨基-2,3-二氢苯甲酸 盐酸盐
CAS 59556-17-1 MFCD00036983
化学结构图
SMILES: Cl.NC1CC(=CC=C1)C(O)=O
化学属性
| Mol. Formula | C7H9NO2· HCl |
|---|---|
| Mol. Weight | 175.61 |
| Melting Point | 203 °C (dec.)(lit.) |
别名和识别编码
| Chemical Name | 3-Amino-2,3-dihydrobenzoic acid hydrochloride |
|---|---|
| CAS Number | 59556-17-1 |
| Synonym | 5-氨基-1,3-环己二烯-1-羧酸 盐酸盐 格巴库林 盐酸盐 3-氨基-2,3-二氢苯甲酸 盐酸盐 d,l-Gabaculine hydrochloride 5-Amino- (+-)-5-Amino-1,3-cyclohexadiene-1-carboxylic acid hydrochloride 格巴库林 盐酸盐 5-氨基-1,3-环己二烯-1-羧酸 盐酸盐 |
| MDL Number | MFCD00036983 |
| PubChem Substance ID | 24278213 |
| Beilstein Registry Number | 4552667 |
| EC Number | 261-802-6 |
| Chemical Name Translation | 3-氨基-2,3-二氢苯甲酸 盐酸盐 |
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分类
- Inhibitors
- Pharmaceuticals
- {SA} A-AM, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, GABA-Transaminase, Neuroscience, Neurotransmission, Neurotransmitter Metabolism
- {SNA} A-AM, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, GABA-Transaminase, Neuroscience, Neurotransmission, Neurotransmitter Metabolism
- Intermediates & Fine Chemicals
- {SNA} Enzyme Inhibitors, GABA-Transaminase, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, 细胞信号转导和神经科学, 细胞生物学
- Amines
产品应用
- An irreversible inhibitor of mouse brain ?-aminobutyric acid (GABA)-?-ketoglutarate transaminase.
相关文献及参考
- Loescher, W., et al.: J. Neurochem., 36, 1521 (1981),
- Pierard, C., et al., Effects of GABA-transaminase inhibition on brain metabolism and amino-acid compartmentation: an in vivo study by 2D 1H-NMR spectroscopy coupled with microdialysis. Exp. Brain Res. 127 , 321, (1999) 摘要
- Fu, M. and Silverman, R.B., Isolation and characterization of the product of inactivation of γ-aminobutyric acid aminotransferase by gabaculine. Bioorg. Med. Chem. 7 , 1581, (1999) 摘要
- FT-NMR 1 (1), 885:A / RegBook 1 (1), 663:F / Structure Index 1 , 98:C:9
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 87 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Skin and Appendages - hair REFERENCE : NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 21,803,1982
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