9-Aminoacridine 9-氨基吖啶

CAS 90-45-9 MFCD00037839

化学结构图

90-45-9
SMILES: Nc1c2ccccc2nc2ccccc12

化学属性

Mol. FormulaC13H10N2
Mol. Weight194.23
Melting Point240-241°C
Appearance 硫黄色针状结晶。熔点241℃,易溶于醇,能溶于丙酮,微溶于氯仿、甲苯和吡啶。
Solubilityethanol: hazy
Boiling Point320.68 °C at 760 mmHg

别名和识别编码

Chemical Name9-Aminoacridine
Synonym 9-Aminoacridine {LY} 9-Aminoacridine {} {LY} 9-Aminoacridine {} {} {LY} 9-Aminoacridine {} {} {} {LY} 9-Aminoacridine {} {} {} {} {LY} 9-Aminoacridine {} {} {} {} {} {LY} 9-Aminoacridine {} {} {} {} {} {} {LY} 9-Aminoacridine {} {} {} {} {} {} {} {LY} 9-Aminoacridine {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} 9-Aminoacridine {} {} {} {} {} {} {} {} {} {LY} 9-Aminoacridine {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} 9-Aminoacridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 9-Aminoacridine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 9-Aminoacridine {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 9-Aminoacridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 9-Aminoacridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 9-Aminoacridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {}
CAS Number90-45-9
EC Number201-995-6
MDL NumberMFCD00037839
Alfabeta NameACRIDINAMINE 9--
Chemical Name Translation9-氨基吖啶
InChIKeyXJGFWWJLMVZSIG-UHFFFAOYSA-N
Wiswesser Line NotationT C666 BNJ IZ
Beilstein Registry Number0141171
LabNetwork Molecule IDLN00178594
Merck Number407
PubChem Substance ID253661219
InChIInChI=1S/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15)
Canonical SMILESNC1=C(C=CC=C2)C2=NC3=CC=CC=C31
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分类

  • {SNA} Mass Spectrometry (MS), Matrix Substances for MALDI-MS, Spectroscopy, 分析/色谱, 分析试剂
  • Analytical Reagents, Analytical/Chromatography, Mass Spectrometry (MS), Matrix Substances for MALDI-MS, Spectroscopy

相关文献及参考

  • 1. Vermillion-Salsbury, R. L. and Hercules, D. M. , 9-Aminoacridine as a matrix for negative mode matrix-assisted laser desorption/ionization Rapid Commun. Mass Spectrom. 16 , 1575-1581, (2002)
  • James L. Edwards, Robert T. Kennedy, Metabolomic Analysis of Eukaryotic Tissue and Prokaryotes Using Negative Mode MALDI Time-of-Flight Mass Spectrometry Anal. Chem. 77 , 2201-2209, (2005) 摘要
  • Gang Sun, Kui Yang, Zhongdan Zhao, Shaoping Guan, Xianlin Han, Richard W. Gross, Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometric Analysis of Cellular Glycerophospholipids Enabled by Multiplexed Solvent Dependent Analyte-Matrix Interactions Anal. Chem. 80 , 7576-7585, (2008) 摘要
  • Gang Sun, Kui Yang, Zhongdan Zhao, Shaoping Guan, Xianlin Han, Richard W. Gross, Shotgun Metabolomics Approach for the Analysis of Negatively Charged Water-Soluble Cellular Metabolites from Mouse Heart Tissue Anal. Chem. 79 , 6629-6640, (2007) 摘要
  • Andrea Amantonico, Joo Yeon Oh, Jens Sobek, Matthias Heinemann, Renato Zenobi, Mass Spectrometric Method for Analyzing Metabolites in Yeast with Single Cell Sensitivity Angew. Chem. Int. Ed. Engl. 47 , 5382-5385, (2008)
  • Merck 14 ,407

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSAR7300000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Warnings IRRITANT
Packing GroupIII
Hazard Codes Xi
Hazard Class6.1(b)
UN Number 2811
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJEPA5 British Journal of Experimental Pathology.  (Blackwell Scientific
   Pub. Ltd., POB 88, Oxford, UK)  V.1-    1920-  Volume(issue)/page/year:
   28,1,1947

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 68 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   IJSBDB Indian Journal of Chemistry, Section B: Organic Chemistry, Including
   Medicinal Chemistry. (Publications & Information Directorate, Council of
   Scientific and Industrial Research (CSIR), Hillside Rd., New Delhi 110 012,
   India)  V.14B-    1976-  Volume(issue)/page/year: 26,318,1987

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 24 umol/L
REFERENCE :
   MGGEAE Molecular and General Genetics.  (Springer-Verlag, Heidelberger Pl.
   3, D-1000 Berlin 33, Fed. Rep. Ger.)  V.99-    1967-
   Volume(issue)/page/year: 138,333,1975

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 8 ug/well
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,429,1981

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 9 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 192,239,1987

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 60 umol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 15,2303,1994

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 118,103,1983

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 200 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Nethe

Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • 下游产品:胰激肽释放酶
  • 储运特性:库房通风低温干燥
  • 急性毒性:腹腔-小鼠LD50: 68毫克/公斤;皮下-小鼠LD50: 80 毫克/公斤
  • 毒性分级:高毒
  • 用途一:防腐剂。9-氨基吖啶的盐酸盐也是防腐剂,显蓝紫色荧光,是荧光最强的物质之一。
  • 方法一:由9-氯吖啶得到。N-苯氨茴酸和五氯化磷一起加热可得到9-氯吖啶。
  • Sigma Aldrich:90-45-9(sigmaaldrich)
  • MOL 文件:90-45-9.mol
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • 可燃性危险特性:可燃;燃烧产生有毒氮氧化物烟雾
  • 上游原料:五氯化磷 --> 邻氨基苯甲酸 --> 9-氯吖啶
  • 类别:有毒物品

系列性分类


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