Hypotaurine 2-氨乙基亚磺酸

CAS 300-84-5 MFCD00038197

化学结构图

300-84-5
SMILES: NCCS(=O)O

化学属性

Mol. FormulaC2H7NO2S
Mol. Weight109.15
SolubilityH2O: 100 mg/mL
Melting Point175-177 °C
Boiling Point354.9±44.0 °C at 760 mmHg

别名和识别编码

Chemical Nameethanesulfinic acid, 2-amino-
Synonym Hypotaurine {LY} Hypotaurine hypotaurine {} {LY} Hypotaurine {} {} {LY} Hypotaurine {} {} {} {LY} Hypotaurine {} {} {} {} {LY} Hypotaurine {} {} {} {} {} {LY} Hypotaurine {} {} {} {} {} {} {LY} Hypotaurine {} {} {} {} {} {} {} {LY} Hypotaurine {} {} {} {} {} {} {} {} {LY} Hypotaurine {} {} {} {} {} {} {} {} {} {LY} Hypotaurine {} {} {} {} {} {} {} {} {} {} {LY} Hypotaurine {} {} {} {} {} {} {} {} {} {} {} {LY} Hypotaurine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hypotaurine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hypotaurine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hypotaurine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hypotaurine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hypotaurine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hypotaurine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hypotaurine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00038197
PubChem Substance ID107812
CAS Number300-84-5
Chemical Name Translation2-氨乙基亚磺酸
Canonical SMILESNCCS(O)=O
InChIInChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)
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分类

  • {SNA} Amino Acid, Amino Acid Library, Bioactive Small Molecules, Building Blocks,
  • {SNA} Amino Acid, Amino Acid Library, Building Blocks, Chemical Synthesis, GABA and Glycine Receptor Modulators, Glycinergics, Ion Channels, Ligand-Gated Ion Channels, Metabolic Libraries, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Neuroscience, Neurotransmission, Neurotransmitters, Organic Building Blocks, Sulfonic/Sulfinic Acids, Sulfur Compounds, 代谢组学, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Amino Acid, Amino Acid Library Collection,

相关文献及参考

  • [2]. Gao P, et al. Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling. Oncotarget. 2016 Mar 22;7(12):15200-14.
  • [3]. Hara K, et al. Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain. Amino Acids. 2012 Jul;43(1):397-404. Hara K, et al. Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain. Amino Acids. 2012 Jul;43(1):397-404.
  • Brand, A., et al., Metabolism of cysteine in astroglial cells: synthesis of hypotaurine and taurine. J. Neurochem. 71 , 827-832, (1998) 摘要
  • Green, T.R., et al., Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils. Biochim. Biophys. Acta 1073 , 91-97, (1991) 摘要
  • Okamoto, K., and Sakai, Y., Inhibitory actions of taurocyamine, hypotaurine, homotaurine, taurine and GABA on spike discharges of Purkinje cells. Brain Res. 206

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
WGK Germany3
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

其他信息

  • color:white
  • Sigma Aldrich:300-84-5(sigmaaldrich)
  • MOL 文件:300-84-5.mol

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Ligand-Gated Ion Channels - Ion Channels
  6. GABA and Glycine Receptor Modulators - Ligand-Gated Ion Channels
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Sulfonic/Sulfinic Acids 磺酸/亚磺酸
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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