Tetracaine Hydrochloride 丁卡因盐酸盐

CAS 136-47-0 MFCD00038912

化学结构图

136-47-0
SMILES: Cl.CCCCNC1C=CC(=CC=1)C(=O)OCCN(C)C

化学属性

Mol. FormulaC15H24N2O2.HCl
Mol. Weight300.83 g/mol
TSCANo
Appearance 盐酸丁卡因(136-47-0)为白色结晶或结晶性粉末、无臭、味微苦，有麻舌感。盐酸丁卡因(136-47-0)在水中易溶，在乙醇中溶解，在乙醚或苯中不溶。盐酸丁卡因(136-47-0)熔点147-150℃。
Melting Point147-150
Solubility水中易溶，在乙醇中溶解，在乙醚或苯中不溶。

别名和识别编码

Chemical NameTetracaine Hydrochloride
CAS Number136-47-0
Synonym ######## 2-(DIMETHYLAMINO)ETHYL 4-(N-BUTYLAMINO)BENZOATE HYDROCHLORIDE 2-(Dimethylamino)ethyl 4-(n-butylamino)benzoate hydrochloride 2-(Dimethylamino)ethyl p-(butylamino)benzoate hydrochloride 2-(dimethylamino)ethylp-(butylamino)benzoatehydrochloride 2-DIMETHYLAMINOETHYL ESTER OFP-BUTYLAMINOBENZOIC ACID HYDROCHLORIDE 2-Dimethylaminoethanol 4-N-butylaminobenzoate hydrochlori 2-Dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride; 4-(Butylamino)benzoic acid 2-(dimethylamino)et 2-dimethylaminoethanol4-n-butylaminobenzoatehydrochloride 4-(BUTYLAMINO)BENZOIC ACID 2-(DIMETHYLAMINO)ETHYL ESTER 4-(丁氨基) 4-(丁氨基)-苯甲酸-2-(二甲氨基)乙酯 4-(丁氨基)-苯甲酸-2-(二甲氨基)乙酯盐酸盐 4-BUTYLAMINOBENZOIC ACID DIMETHYLAMINOETHYL ESTER HCL 4-[BUTYLAMINO]BENZOIC ACID-2-[DIMETHYLAMINO]ETHYL ESTER HYDROCHLORIDE Amethocaine
MDL NumberMFCD00038912
PubChem Substance ID87577427
EC Number205-248-5
Merck Number9188
Chemical Name Translation丁卡因盐酸盐
Beilstein Registry Number3918400
Reaxys-RN3918400
Wiswesser Line Notation4MR DVO2N1&1 &GH
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分类

  • {SNA} Calcium Channel Modulators, Inhibitors and Activators, Ion Channels, Voltage-gated Ion Channels, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Core Bioreagents, Enzyme Inhibitors, Pharmacopoeia, Pharmacopoeia A-Z, Pharmacopoeial Antibiotics, Research Essentials, 分析/色谱
  • {SNA} Analytical Standards,
  • {SNA} Bioactive Small Molecule Alphabetical Index, Ion Channels, Monovalent Ion Channels, Potassium Channel Modulators, T, Voltage-gated Ion Channels, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Analytical Standards, Pharmacopeia Metrological Institutes Standards, USP

产品应用

  • A local anesthetic used topically in opthalmology.

相关文献及参考

  • Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),
  • Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),
  • Short: III/31a
  • Short: EINECS
  • Merck: 14,9188

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310+P330
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P405 Store locked up. 上锁保管。
  • P301+P310
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P337+P313
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H301 Toxic if swallowed 吞食有毒
Signal word
Hazard Codes T
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S24 Avoid contact with skin 避免皮肤接触；
  • S20 When using do not eat or drink 使用时，不得进食，饮水；
  • S22 Do not breathe dust 不要吸入粉尘；
  • S37 Wear suitable gloves 戴适当手套；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R36 Irritating to eyes 刺激眼睛
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R42/43
UN Number
RTECSDG4900000
Packing GroupIII
Storage condition 密封保存
Hazard Class6.1 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 19500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   20,380,1947

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6400 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,815,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 7,739,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARPMAS Archiv der Pharmazie (Weinheim, Germany)  (VCH Pub., Inc., 303 NW
   12th Ave., Deerfield Beach, FL 33441)  V.51-261, 1835-1923; V.305-    1972-
   Volume(issue)/page/year: 321,115,1988

TYPE OF TEST

其他信息

  • 用途一:局部麻醉药。
  • 用途二:盐酸丁卡因【136-47-0】局麻作用比普鲁卡因强，毒性亦较大，能透过粘膜，主要用于粘膜麻醉。
  • MSDS 信息:Tetracaine hydrochloride(136-47-0).msds
  • 盐酸丁卡因价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 T1688 盐酸丁卡因 Tetracaine Hydrochloride 5G 310元 2014/06/02 T1688 盐酸丁卡因 Tetracaine Hydrochloride 25G 849元
  • MOL 文件:136-47-0.mol
  • Sigma Aldrich:136-47-0(sigmaaldrich)
  • TCI Shanghai:盐酸丁卡因 Tetracaine Hydrochloride,>;98.0%(LC)(T)(136-47-0)
  • 图谱信息:盐酸丁卡因(136-47-0)核磁图( 13 CNMR) 盐酸丁卡因(136-47-0)质谱(MS) 盐酸丁卡因(136-47-0)红外图谱(IR2) 盐酸丁卡因(136-47-0)红外图谱(IR1) 盐酸丁卡因(136-47-0)核磁图( 1 HNMR)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. T - Bioactive Small Molecules
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Voltage-gated Ion Channels - Ion Channels
  6. Monovalent Ion Channels - Voltage-gated Ion Channels
  7. Potassium Channel Modulators - Monovalent Ion Channels

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