Sodium tert-butoxide 叔丁醇钠

CAS 865-48-5 MFCD00040575

化学结构图

865-48-5
SMILES: CC(C)(C)[O-].[Na+]

化学属性

Melting Point180°C
Solubility起反应
TSCAYes
Refractive indexn20/D 1.413
Flash Point12°C
Boiling Point180°C/1mmHg
Appearance white to off-white pwdr.
Stabilitymoisture sensitive
Density0.9294
Mol. FormulaC4H9NaO
Mol. Weight96.10
RedoxReduction

别名和识别编码

Chemical NameSodium tert-butoxide
PubChem Substance ID23676156
EC Number212-741-9
Beilstein Registry Number8402623
Reaxys-RN8402623
Synonym 2-Methyl-2-propanol sodium salt 2-Propanol, 2-methyl-, sodium salt Degassed and low oxygen sodium tert-butoxide solution NatB SODIUM TERT-BUTOXIDE SODIUM TERT-BUTYLATE SODIUM TERTIARY BUTOXIDE STB Sodium 2-methylpropan-2-olate; NatB Sodium t-butoxide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {Chemicalbook} sodiumt-butoxide,stb,intetrahydrofuran {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {Chemicalbook} sodiumt-butoxide,stb,in {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {Chemicalbook} sodiumt-butoxide,stb {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Chemical Name Translation叔丁醇钠
InChIKeyMFRIHAYPQRLWNB-UHFFFAOYSA-N
LabNetwork Molecule IDLN00163314
MDL NumberMFCD00040575
CAS Number865-48-5
Canonical SMILESCC(C)(O[Na])C
InChIInChI=1S/C4H9O.Na/c1-4(2,3)5;/h1-3H3;/q-1;+1
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分类

  • {SNA} 25mL Sure/Seal Reage
  • {SNA} Acids & Bases, Bases, Chemical Synthesis, Organic Bases,
  • {SNA} Acids & Bases, Bases, Chemical Synthesis, Materials Science, Micro/NanoElectronics, Organic Bases, Sodium,
  • Chemical Synthesis, Materials Science, Micro/NanoElectronics,

产品应用

  • 作为强碱广泛应用于化工、医药、农药等有机合成中的缩合、重排和开环等反应中。

相关文献及参考

  • Beilstein:1(4)1609
  • Preferred base, superior to KO-t-Bu or LiO-t-Bu, for promoting Buchwald's Pd catalyzed conversion of aryl bromides to arylamines: Angew. Chem. Int. Ed., 34, 1316, 1348 (1995); J. Org. Chem., 61, 7240 (1996); Tetrahedron Lett., 39, 2219 (1998).

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H228 Flammable solid 易燃固体
  • H251 Self-heating: may catch fire 自我放热：可能着火
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H351 Suspected of causing cancer 怀疑致癌
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes 4.2 F,C
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P235 Keep cool. 保持凉爽。
  • P235+P410
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331
  • P301+P330+P331+P310
  • P302+P361+P354
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P316
  • P317
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P407 Maintain air gap between stacks/pallets. 在堆叠/货板间保持气隙。
  • P410 Protect from sunlight. 防止阳光照射。
  • P413 Store bulk masses greater than … kg/…lbs at temperatures not exceeding … oC/…oF. 商店散装超过…kg/…lbs 时温度不应超过…oC/…oF.
  • P420 Store away from other materials. 远离其他材料。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
UN Number 3206
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 着火时使用（指明具体的消防器材种类，如果用水增加危险，注明“禁止用水”
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S7/8 Keep container tightly closed and dry 保存在严格密闭容器中，保持干燥；
Risk Statements
  • R11 Highly flammable 非常易燃
  • R14 Reacts violently with water 遇水会猛烈反应
  • R19 May form explosive peroxides 可能生成易爆的过氧化物质
  • R34 Causes burns 会导致灼伤
  • R35 Causes severe burns 会导致严重灼伤
  • R37 Irritating to respiratory system 刺激呼吸道
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
Storage condition 2-8°C, sealed storage, away from moisture Air & Moisture Sensitive Flammables area 充氩保存 对空气和湿度敏感，密封保存。
Packing GroupII
Hazard Class4.2/8

其他信息

  • Sigma Aldrich:865-48-5(sigmaaldrich)
  • 海关编码:29051900
  • Alfa Aesar:叔丁醇钠,97% Sodium tert-butoxide, 97%(865-48-5)
  • 和水反应。
  • MSDS 信息:Sodium 2-methylpropan-2-olate(865-48-5).msds
  • Acros Organics:叔丁醇钠 Sodium tert-butoxide, pure, 98%(865-48-5)
  • 下游产品:叔丁醇 --> 2-氨基-7-甲氧基四氢萘 --> 6,6'-二甲基-2,2'-联吡啶 --> 1-(4-吡啶基)哌嗪 --> N,N'-二苯基-N,N'-(1-萘基)-1,1'-联苯-4,4'-二胺 --> 3-吗啉基苯甲醛 --> 氟马西尼 --> 3-吗啉苯酚 --> 5 5'-二甲基-2,2-联吡啶 --> 4-苄氧基-2-氯嘧啶,95% --> 3-(2-氯-3,3,3-三氟-1-丙烯基)-2,2-二甲基环丙烷羧酸甲酯 --> 2,4,5-三氟苯乙酸
  • TCI Shanghai:叔丁醇钠 Sodium tert-Butoxide,>;98.0%(T)(865-48-5)
  • 敏感性:Air Sensitive & Hygroscopic
  • 存储注意事项:氮气保护
  • MOL 文件:865-48-5.mol
  • F:1-3-10
  • 叔丁醇钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 S0450 叔丁醇钠 Sodium tert-Butoxide 100G 221元 2014/06/02 S0450 叔丁醇钠 Sodium tert-Butoxide 25G 88元 2014/06/02 S0450 叔丁醇钠 Sodium tert-Butoxide 500G 698元
  • 用途二:作为强碱广泛应用于化工、医药、农药等有机合成中的缩合、重排和开环等反应中。
  • 用途一:用作有机合成中间体、医药中间体
  • TSCA:Yes

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Acids - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Bases - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Bases - Synthetic Reagents
  1. Materials Science 材料科学
  2. Micro/NanoElectronics - Materials Science
  3. Solution Deposition Precursors - Micro/NanoElectronics
  4. Sodium - Solution Deposition Precursors
  1. Alkoxide
  2. Sodium

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