Chlorpyrifos 毒死蜱
CAS 2921-88-2 MFCD00041800
化学结构图
SMILES: CCOP(=S)(OCC)Oc1nc(Cl)c(Cl)cc1Cl
化学属性
| Mol. Formula | C9H11Cl3NO3PS |
|---|---|
| Mol. Weight | 350.59 |
| Melting Point | 42-44 ºC |
| Boiling Point | 200 ºC |
| Density | 1.0 |
| Solubility | 不溶. 0.00013 G/100 ML |
| Flash Point | 2 °C |
别名和识别编码
| Chemical Name | Chlorpyrifos |
|---|---|
| CAS Number | 2921-88-2 |
| Synonym | chlorpyrifos Lorsban 50SL dursban hf { O,O-Diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate 乐斯本 毒死蜱 溶液 Pyrinex {Chemica Eradex D 毒死蜱 {Chemi chlorpyrifos (ISO) {Chem 乐斯本,陶斯松 pyrinex Detmol U.A. Dowco 179 ENT-27311 CHLORPYRIPHOS Py 硫代磷酸-O,O-二乙基-O-(3,5,6-三氯-2-吡啶基)酯 O,O-二乙基-0-( Affront clorpyrifos 98%毒死蜱原药 Phosphorothioic Acid O,O-Diethyl O-(3,5,6-Trichloro-2-pyridinyl)ester Chlorpyrifos Chlorpyritos CHLOROPYRIPHOS Chlorpyriphos Dursban F LORSBAN lorsban Phosphorothioic acid O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester 蓝珠 O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl)phosphorothioate O,O-Diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate; Phosphorothioic acid O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester; Chlorpyrifos-ethyl; Chlorpyritos; Clorpyrifos; Dowco 179; Dursban HF; Eradex; Lorsban 4E-SG; Pyrinex; Super I.Q.A.P.T.; Trichlorpyrphos DURSBAN dursban O,O-DIETHYL O-(3,5,6-TRICHLORO-2-PYRIDYL)-THIOPHOSPHATE O,O-diethyl O-3,5,6-tr 泰乐凯 O,O-Diethyl-O-(3,5,6-trichlor 乐施苯 phosphorothioic acid |
| MDL Number | MFCD00041800 |
| PubChem Substance ID | 2730 |
| Beilstein Registry Number | 1545756 |
| EC Number | 220-864-4 |
| Chemical Name Translation | 毒死蜱 |
| Merck Number | 13,2208 |
| Wiswesser Line Notation | T6NJ BOPS&O2&O2 CG EG FG |
| LabNetwork Molecule ID | LN01273007 |
| InChI | InChI=1S/C9H11Cl3NO3PS/c1-3-14-17(18,15-4-2)16-9-7(11)5-6(10)8(12)13-9/h5H,3-4H2,1-2H3 |
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分类
- {SNA} Acaricides,
- {Chemicalbook} 农药: 杀虫（螨）剂: 有机磷杀虫剂
- {SNA} Analytical Standards, Analytical/Chromatography, C, Chromatography, Environmental Standards, Nematicides, Organophosphate, Pesticide Class, 农残和代谢标准品, 农残标准品,
- {SNA} Analytical Standards, Analytical/Chromatography, CRMs, Certified Reference Materials (CRMs), Chromatography, Environmental Standards, Fluka CRM for chromatography (neats), Organic CRMs Alphabetical, Organic CRMs TraceCERT, Organophosphate, Pesticide Class, Pesticides, Pesticides & Metabolites, Pesticides, suspected to harm bees
- {SNA} Acaricide
- {SNA} Analytical Standards,
- {SN
产品应用
- 非内吸性的广谱杀虫剂，具有接触，胃毒和熏蒸的作用。用于玉米，棉花，大豆，花生，天才，果树，蔬菜，防治多种那个土壤和叶面害虫。也用于防治蚊蝇，蟑螂，白蚁等家庭害虫。粮仓害虫和家畜体外寄生虫。毒性：大鼠经口LD50135-163mg/kg。
相关文献及参考
- Short: IV/8A
- Short: EINECS
- Smith, G.N., et al.: J. Agric. Food Chem., 15, 132 (1967),
- Merck: 14,2189
安全信息
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S1/2 None 上锁保管并避免儿童触及；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
- R11 Highly flammable 非常易燃
- R50/53
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R36 Irritating to eyes 刺激眼睛
- R25 Toxic if swallowed 吞咽有毒
- R38 Irritating to skin 刺激皮肤
GHS Symbol
- P273 Avoid release to the environment. 避免释放到环境中。
- P301+P310+P330
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P304+P340+P310
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P305+P351+P338
- P301+P310
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- H301 Toxic if swallowed 吞食有毒
- H319 Causes serious eye irritation 严重刺激眼睛
- H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
- H302+H312+H332
- H332 Harmful if inhaled 吸入有害
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - duck DOSE/DURATION : 76 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 20,57,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - pigeon DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911- Volume(issue)/page/year: (680),157,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - chicken DOSE/DURATION : 25400 ug/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold REFERENCE : TXAPA9 Toxicology and App
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 78-1,45,1978
TYPE OF TEST
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 500 ug/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 279,165,1992
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 1 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 279,165,1992
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 2 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 102,89,1982
TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 50 ppb REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5,835,1983
TYPE OF TEST : Specific locus test ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 50 ppb REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 279,15,1992
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 210 ug/kg SEX/DURATION : female 1-7 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System REFERENCE : VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 34,498,1992
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 4500 ug/kg SEX/DURATION : female 7-21 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System REFERENCE : VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 34,498,1992
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 200 mL/kg SEX/DURATION : female 12 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - Central Nervous System REFERENCE : JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 44,189,1995
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 50 mg/kg SEX/D
其他信息
- 毒性:雄性大鼠急性经口LD 50 为163mg/kg，雌性为135mg/kg，豚鼠为500mg/kg；兔急性经口LD 50 为2000mg/kg。对动物眼睛有轻度刺激，对皮肤有明显刺激，多次接触产生灼伤。对大鼠慢性经口无作用剂量为每天0.1mg/kg。虹鳟鱼LC 50 为15mg/L (96h)。对蜜蜂有毒。
- 下游产品:乳油 --> 甲基毒死蜱
- 乙溶于大多数有机溶剂。在通常储存条件下稳定，水解速率随温度和ph值增高而加快。在25℃和ph8的条件下，水解50%需1.5d，在15℃和ph7的条件下，水解50%需100d，对酮有腐蚀性。
- 外观性质:白色颗粒状结晶，有硫醇臭味。
- 类别:农药
- 图谱信息:毒死蜱(2921-88-2)红外图谱(IR2) 毒死蜱(2921-88-2)质谱(MS) 毒死蜱(2921-88-2)核磁图( 13 CNMR) 毒死蜱(2921-88-2)红外图谱(IR1) 毒死蜱(2921-88-2)核磁图( 1 HNMR)
- 灭火剂:砂土、干粉、泡沫
- 急性毒性:口服-大鼠 LD50: 82 毫克/公斤; 口服-小鼠 LD50: 60 毫克/公斤
- Sigma Aldrich:2921-88-2(sigmaaldrich)
- 储运特性:库房通风低温干燥; 与食品原料分开储运
- 中毒症状:急性中毒多因误食引起，约半小时到数小时可发病。 轻度中毒：全身不适，头痛、头昏、无力、视力模糊、呕吐、出汗、流涎、嗜睡等，有时有肌肉 震颤，偶有腹泻 中度中毒：除上述症状外剧烈呕吐、腹痛、烦燥不安、抽搐、呼吸困难等 重度中毒：癫痫样抽搐。急性中
- 用途四:非内吸性的广谱杀虫剂，具有接触、胃毒和熏蒸作用。用于玉米、棉花、大豆、花生、甜菜、果树、蔬菜、防治多种土壤和叶面害虫。也用于防治蚊蝇、蝉螂、白蚁等家庭害虫、粮仓害虫和家畜体外寄生虫。毒性：大鼠经口LD50135-163mg/kg。
- 急救治疗:[1]用阿托品1～5mg皮下或静脉注射(按中毒轻重而定) [2]用解磷定0.4－1.2g 静脉注射( 按中毒轻重而定) [3]禁用吗啡、茶硷、吩噻嗪、利血平。
- 用途二:用于棉花、水稻、玉米、小麦及茶树等多种作物杀虫和杀螨
- 用途五:非内吸性的广谱杀虫剂，具有接触，胃毒和熏蒸的作用。用于玉米，棉花，大豆，花生，天才，果树，蔬菜，防治多种那个土壤和叶面害虫。也用于防治蚊蝇，蟑螂，白蚁等家庭害虫。粮仓害虫和家畜
- 上游原料:二氯甲烷 --> 氯化钠 --> 氯 --> 苄基三乙基氯化铵 --> 二乙基硫代磷酰氯 --> 三氯乙酸 --> N-甲基咪唑 --> 喹硫磷 --> 三氯乙酰氯 --> 3,5,6-三氯吡啶-2-醇钠盐 --> 4-羟基-3-甲基苯乙酮 --> 2,3,5,6-四氯吡啶 --> 五氯吡啶 --> 3,5,6-三氯吡啶-2-醇 --> 2,3,6-三氯吡啶
- 用途五:非内吸性的广谱杀虫剂，具有接触，胃毒和熏蒸的作用。用于玉米
- 用途一:是硫代磷酸酯类杀虫剂，具有触杀、胃毒和熏蒸作用。在叶片上的残留期不长，但在土壤中的残留期则较长，因此对地下害虫的防治效果较好。在推荐剂量下，对多数作物没有药害，但对烟草敏感
- 方法一:O，O-二乙基硫代磷酰氯的制备 见喹硫磷的合成。 2-羟钠-3，5，6-三氯吡啶的制备 在催化剂在存在下，吡啶于330℃与氯气发生氯化反应，生成五氯吡啶。然后以乙腈为溶剂，于78℃滴加锌粉/氯化铵水溶液，反应3h得2，3，5，6-四氯吡啶，在碱性条件下，四氯吡啶于95～100℃发生水解，硫酸酸化至pH值3.5，得2-羟基-3，5，6-三氯吡啶。 也可用于下述工艺过程制备相应的羟基氯代吡啶。 毒死蜱合成 将2-羟基-3，5，6-三氯吡啶在NaOH水溶液中溶解，降温，加入少量氯化钠、氢氧化钠、硼酸、苄基三乙基氯化铵（相转移催化剂）、1-甲基咪唑及溶剂二氯甲烷，加热至42℃，于搅拌下加入O，O-二乙基硫代磷酰氯，加毕回流1.5h，
- 方法二:由二乙基硫代磷酰氯与3,5,6-三氯-2-吡啶醇反应制得。
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