MYXOTHIAZOL

CAS 76706-55-3 MFCD00043397

化学结构图

76706-55-3
SMILES: CC(C)/C=C/C=C/[C@H](C)C1=NC(=CS1)C1=NC(=CS1)/C=C/[C@H](OC)[C@@H](C)/C(=C/C(N)=O)/OC

化学属性

Mol. FormulaC25H33N3O3S2
Mol. Weight487.73

别名和识别编码

Chemical Name2,6-Heptadienamide,7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy- 4-methyl-
MDL NumberMFCD00043397
PubChem Substance ID24897044
Synonym Myxothiazol
CAS Number76706-55-3
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分类

  • {SNA} Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antifungal, Bioactive Small Molecules, Cell Biology, Chemical Structure Class, Inhibits an Enzyme, M, Mechanism of Action, Peptides, Spectrum of Activity

相关文献及参考

  • [2]. von Jagow G,et al. An inhibitor of mitochondrial respiration which binds to cytochrome b and displaces quinone from the iron-sulfur protein of the cytochrome bc1 complex. J Biol Chem. 1984;259(10):6318-6326.
  • [3]. Davoudi M, et al. A mouse model of mitochondrial complex III dysfunction induced by myxothiazol. Biochem Biophys Res Commun. 2014;446(4):1079-1084.
  • [1]. Thierbach G, et al. Myxothiazol, a new antibiotic interfering with respiration. Antimicrob Agents Chemother. 1981;19(4):504-507.
  • [1]. Thierbach G, et al. Myxothiazol, a new antibiotic interfering with respiration. Antimicrob Agents Chemother. 1981;19(4):504-507.
  • [2]. von Jagow G,et al. An inhibitor of mitochondrial respiration which binds to cytochrome b and displaces quinone from the iron-sulfur protein of the cytochrome bc1 complex. J Biol Chem. 1984;259(10):6318-6326.
  • [3]. Davoudi M, et al. A mouse model of mitochondrial complex III dysfunction induced by myxothiazol.

安全信息

WGK Germany3
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P301+P310
Hazard statements
  • H300 Fatal if swallowed 吞食致命
RTECSQH7580000
Signal word Danger
GHS Symbol
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 33,1474,1980

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics G-M - Antibiotics A to Z
  1. Medical Research Areas
  2. Metabolism
  3. Mitochondrial Metabolism  (线粒体代谢)

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