Hydroxylamine 羟胺

CAS 7803-49-8 MFCD00044522

化学结构图

7803-49-8
SMILES: NO

化学属性

Mol. FormulaH3 N O
Mol. Weight33.03
Density1.078 g/mL at 25 °C
Boiling Point
Vapor Pressure9 mmHg ( 40 °C)
Refractive index1.3940
Flash PointNone
TSCAYes
Melting PointNo Data Available
Appearance 不稳定的白色大片状或针状结晶。极易吸潮，极易溶于水。当浓度为100%、10%、20%、30%、40%、50%时水溶液的相对密度分别为：1.2040、1.0192、1.0410、1.0637、1.0875、1.1122。该品在热水中分解，微溶于乙醚、苯、二硫化碳、氯仿。熔点32.05℃，沸点70℃（1.33kPa）。

别名和识别编码

Chemical NameHydroxylamine
Synonym FH-50 FH-50TM H2NOH HDA HYDROXYLAMINE HYDROXYLAMINE SOLUTION, ~50% IN WATER HYDROXYLAMINE, 50 WT. % SOLUTION IN WATE R HYDROXYLAMINE, 99.999%, 50 WT. SOLUTION IN WATER HYDROXYLAMINE,FREEBASE,50%AQUEOUSSOLUTION HYDROXYLAMINE: 50% AQUEOUS SOLUTION Hydroxyamine Hydroxylamine Solution (50 wt. % in H2O) {} {} {} {} {} {} {LY} Hydroxylamine Solution(50 wt. % in H2O) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL NumberMFCD00044522
CAS Number7803-49-8
PubChem Substance ID787
EC Number232-259-2
Merck Number14,4828
Beilstein Registry Number1098214
Chemical Name Translation羟胺
Reaxys-RN3587190
Wiswesser Line NotationZQ
LabNetwork Molecule IDLN01309816
InChIInChI=1S/H3NO/c1-2/h2H,1H2
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分类

  • {SNA} C-X Bond Formation (Non-Halogen), Chemical Synthesis, Others, Synthetic Reagents
  • {SNA} C-X Bond Formation (Non-Halogen), Chemical Synthesis, Other Non-Halogen Reagents for C-X Bond Formation, Synthetic Reagents
  • {uni_hamburg} no charge; 1fragment

相关文献及参考

  • Short: II/25A Title: Structure Data Of Free Polyatomic Molecules: Inorganic Molecules Author: Graner, G.; Hirota, E.; Iijima, T.; Kuchitsu, K.; Ramsay, D.A.; Vogt, J.; Vogt, N. Editor: Kuchitsu, K. Source: Landolt-Börnstein, New Series Volume: II/25A Year: 1998 Keyword: Free Polyatomic Molecules; Inorganic Molecules; Molecules ISBN: 3-540-61713-2 ISBN: 978-3-540-61713-6 Internet Resource: DOI:10.1007/b59072 RefComment: VII, 359 pages. Hardcover Abstract: Volume II/25 is a supplemented and revised edition of the preceding volumes II/7, II/15, II/21 and II/23 containing up to date information on inorganic and organic polyatomic molecules. All experimental methods for the determination of quantitative structural data of free molecules have been considered: microwave, infrared, Raman, electronic and photoelectron spectroscopy as well as electron diffraction. The data obtained by these methods have been critically evaluated and compiled. They are presented separately for each molecule, together with a schematic figure of the structure and the original literature.
  • Short: III/35E Title: Nuclear Magnetic Resonance (NMR) Data: Chemical Shifts for Oxygen-17 Author: Duddeck, H.; Toth, G.; Simon, A. Editor: Gupta, R.R.; Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/35E Year: 2002 Keyword: Alipathic and Aromatic hydrocarbons; Coupling constant j; Nuclear Magnetic Resonance; chemical shifts δ ISBN: 3-540-42501-2 ISBN: 978-3-540-42501-4 Internet Resource: DOI:10.1007/b92953 RefComment: VII, 230 pages. With CD-ROM., Hardcover Abstract: This volume provides a comprehensive and evaluated compilation of nuclear magnetic resonance data. Chemical shifts and coupling constants of boron-11 and phosphorus-31 (subvol. A), fluorine-19 and nitrogen-15 (subvol. B), hydrogen-1 (subvol. C), carbon-13 (subvol. D), and oxygen-17 (subvol. E) compounds are tabulated together with the gross- and structure formulas and the most readily available solvent

安全信息

WGK Germany3
Precautionary statements
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P337+P313
  • P234 Keep only in original container. 只保留在原来的容器中。
  • P403+P233
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P303+P361+P353
  • P304+P340
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P308+P311
  • P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
  • P301+P330+P331
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P405 Store locked up. 上锁保管。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P333+P313
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
Signal word Danger
Hazard statements
  • H290 May be corrosive to metals 可能腐蚀金属。
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H302 Harmful if swallowed 吞食有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H351 Suspected of causing cancer 怀疑致癌
  • H318 Causes serious eye damage 严重伤害眼睛
  • H315 Causes skin irritation 会刺激皮肤
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H302+H312
  • H371 May cause damage to organs 可能导致器官损伤
RTECSNC2975000
GHS Symbol
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Packing GroupIII
UN Number 3082 UN3266 UN 3082 9/PG 3 3266
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R48/20/21/22
  • R50 Very toxic to aquatic organisms 对水生生物极毒
  • R5 Heating may cause an explosion 加热会引起爆炸
  • R48/22
  • R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
Safety Statements
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
  • S47 Keep at temperature not exceeding ... °C (to be specified by the manufacturer) 保持温度不超过……°C（由生产厂家指定）；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S46 If swallowed, seek medical advice immediately and show this container or label 食入时，立即求医并出示容器/标签；
  • S57 Use appropriate containment to avoid environmental contamination 使用适当容器避免环境污染；
  • S22 Do not breathe dust 不要吸入粉尘；
Hazard Codes Xn;N Xn,N
Hazard Class8
Storage condition +4°C 0-10°C 4 4℃ 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   6,160,1952

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 29 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 119,444,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 165,30,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 59 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   26,1448,1966

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 20 mmol/L
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   148,507,1965

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 pph
REFERENCE :
   AGACBH Agents and Actions, A Swiss Journal of Pharmacology.  (Birkhaeuser
   Verlag, POB 133, CH-4010 Basel, Switzerland)  V.1-    1969/70-
   Volume(issue)/page/year: 4,286,1974

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 400 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 22,223,1974

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 93,447,1982

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 23 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 16,165,1972

TYPE OF TEST            : Mutation in microorgan

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 pph
REFERENCE :
   AGACBH Agents and Actions, A Swiss Journal of Pharmacolo

TYPE OF TEST

{hazard_c

其他信息

  • 可燃性危险特性:受热分解有毒氮氧化物烟雾
  • Alfa Aesar:羟胺,50%水溶液 Hydroxylamine, 50% aq. soln.(7803-49-8)
  • 上游原料:乙醇钠 --> 1-氨基乙醇 --> 磷酸羟胺
  • 毒性分级:高毒
  • 类别:腐蚀物品
  • F:4.8
  • 灭火剂:水、二氧化碳、砂土
  • 羟胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/05/25 B22202 羟胺, 50% 水溶液 Hydroxylamine, 50% aq. soln. 500ml 1305元 2010/05/25 B22202 羟胺, 50% 水溶液 Hydroxylamine, 50% aq. soln. 100ml 413元
  • 急性毒性:腹腔-大鼠 LD50： 59 毫克/公斤； 腹腔- 小鼠 LD50: 60 毫克/ 公斤
  • 蒸气压:9 mm Hg ( 40 °C)
  • MOL 文件:7803-49-8.mol
  • Sigma Aldrich:7803-49-8(sigmaaldrich)
  • 用途一:在有机合成中用作还原剂。
  • 方法一:用盐酸羟胺乙醇溶液加乙醇钠，将析出的氢氧化钠迅速滤出，滤液冷至-18℃结晶，过滤，得羟胺。将磷酸羟胺加热蒸馏（1.73kPa下操作），收集135-137℃馏分，亦可得羟胺粗品。
  • 储运特性:库房通风低温干燥; 与可燃物分开存放
  • 爆炸物危险特性:高温爆炸

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. C-X Bond Formation (Non-Halogen) - Synthetic Reagents
  4. Others - C-X Bond Formation (Non-Halogen)
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. C-X Bond Formation (Non-Halogen) - Synthetic Reagents
  4. Others - C-X Bond Formation (Non-Halogen)

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