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分类

• {SNA} Alcohols, Amines, Building Blocks, C9, C9 to C10, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks, Oxygen Compounds
• {SNA} Analytical Standards, EP Standards, EP Standards P - R, Pharmacopeia Metrological Institutes Standards, 分析/色谱
• {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards P - R, Pharmaceutical Standards, Pharmacopeia Standards
• {SNA} Analytical Standards, EP Standards, EP Standards P - R, Pharmacopeia & Metrological Institutes Standards, 分析/色谱

相关文献及参考

• [2]. Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36.
• [3]. Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1;21:502-13.
• [4]. Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 ( Pt 2):459-65.
• [5]. Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28(1):1-6.
• [1]. Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoce
• [1]. Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35.

安全信息

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Ocular
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 188 ug/kg
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
REFERENCE :
   ANESAV Anesthesiology.  (Lippincott/Harper, Journal Fulfillment Dept., 2350
   Virginia Ave., Hagerstown, MD 21740)  V.1-    1940- Volume(issue)/page/year:
   36,

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraduodenal
SPECIES OBSE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 38 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Cardiac - pulse rate increase, without fall in BP
   Skin and Appendages - hair
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   38,474,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Ocular
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 5500 ug/kg
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
REFERENCE :
   ANESAV Anesthesiology.  (Lippincott/Harper, Journal Fulfillment Dept., 2350
   Virginia Ave., Hagerstown, MD 21740)  V.1-    1940- Volume(issue)/page/year:
   36,187,1972

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 20 ug/kg
SEX/DURATION            : female 16 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 143,170,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 40 ug/kg
SEX/DURATION            : female 16 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - blood and lymphatic
   systems (including spleen and marrow)
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 143,170,1982

其他信息

• 用途一:拟肾上腺素药物，用于外科手术延长局部麻醉时间、鼻粘膜充血、急性低血压、感染中毒性及过敏性休克等症
• MOL 文件:59-42-7.mol
• TCI Shanghai:L-苯肾上腺素 L-Phenylephrine,>;98.0%(T)(59-42-7)
• Sigma Aldrich:59-42-7(sigmaaldrich)
• 去氧肾上腺素碱价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 P0395 L-苯肾上腺素 L-Phenylephrine 5G 1100元 2014/06/02 P0395 L-苯肾上腺素 L-Phenylephrine 25G 3320元
• 图谱信息:去氧肾上腺素碱(59-42-7)质谱(MS) 去氧肾上腺素碱(59-42-7)核磁图( 1 HNMR) 去氧肾上腺素碱(59-42-7)红外图谱(IR2) 去氧肾上腺素碱(59-42-7)红外图谱(IR1) 去氧肾上腺素碱(59-42-7)Raman光谱