4,4'-Methylenebis(2-Chloroaniline) 4,4-亚甲基双(2-氯苯胺)

CAS 101-14-4 MFCD00047829

化学结构图

101-14-4
SMILES: Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl

化学属性

Mol. FormulaC₁₃H₁₂Cl₂N₂
Mol. Weight267.15
Boiling Point
Melting Point102-105°C
Density1.44
Solubility<0.1 G/100 ML AT 25 ºC
Flash Point>;230 °F
Appearance 白色至淡黄色疏松针晶，加热变黑色。微有吸湿性。 溶于酮和芳香烃。

别名和识别编码

Chemical Name4,4'-Methylenebis(2-Chloroaniline)
CAS Number101-14-4
Alfabeta NameAMINOCHLOROBENZYLCHLOROPHENYLAMINE 4432[]()------
MDL NumberMFCD00047829
Synonym 2,2'-Dichlor-4,4'-methylendianilin 2,2-DICHLORO-4,4'-METHYLENEDIANILINE 2,2′-Dichloro-4,4′-methylenedianiline 3,3'-Dichlor-4,4'-diaminodiphenylmethan 3,3'-Dichloro-4,4'-diaminodiphenylmethane 3,3’-二氯-4,4’-二氨基二苯甲烷 4, 4,4'-Methylenebis (2-chloroaniline) 4,4'-Methylenebis(2-chloroaniline) 4,4'-Methylenebis(o-chloroaniline) 4,4'-DIAMINO-3,3'-DICHLORODIPHENYLMETHANE 4,4'-METHYLENE B 4,4'-Methylenebis(2-chloroaniline) (~90%) {Chemicalbook} METHYLENEBIS(2-CHLOROANILINE) RCRA wast {} {uni_hamburg} CPP 100 {} {} {uni_hamburg} CL-MDA {} {} {} {Chemicalbook} CHEMBRDG-BB 5180272 {} {} {} {} {} {} {} {} {uni_hamburg} Bisamine S {} {} {} {} {} {uni_hamburg} p,p'-Methylenebis[o-chloroaniline] {
PubChem Substance ID87572634
EC Number202-918-9
Beilstein Registry Number1882318
Reaxys-RN1882318
Merck Number6059
Chemical Name Translation4,4-亚甲基双(2-氯苯胺)
Wiswesser Line NotationZR CG D1R DZ CG
LabNetwork Molecule IDLN00160887
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分类

  • {SNA} All alphabetical sorted, Analytical Standards, Analytical/Chromatography, Chromatography, Colors
  • {SNA} Amine Monomers,
  • {SNA} 2002/61/EC, Alphabetical Index of Analytical Standards, Amines, Analytical Standards, Analytical/Chromatography, Aromatics, Aryl Amines MAK III, Category 2, Chemical Class,

产品应用

  • 用于测定商品中偶氮染料所释放的芳香胺的标准品

相关文献及参考

  • Merck:6059
  • Short: EINECS
  • Merck:6059 Beilstein: 13,I,74
  • Short: III/15a

安全信息

Warnings 危化品目录(2015) IRRITANT
GHS Symbol
WGK Germany3
Hazard statements
  • H350 May cause cancer 可能致癌
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H302 Harmful if swallowed 吞食有害
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312+P330
  • P305+P351+P338+P337+
  • P308+P313
  • P332+P313
  • P337+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard Codes 9 T,N
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R45 May cause cancer 可能致癌
  • R50/53
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
UN Number 2018 3077 UN 3077 9/PG 3
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSCY1050000
Packing GroupIII
Hazard Class9 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 34 gm/kg/80W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Liver - tumors
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   31,159,1975

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 27 gm/kg/79W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Liver - tumors
REFERENCE :
   NATWAY Naturwissenschaften.  (Springer-Verlag, Heidelberger Platz 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.1-    1913-  Volume(issue)/page/year:
   58,578,1971

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8100 mg/kg/77W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Endocrine - tumors
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 2(1),149,1978

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Skin and Appendages - tumors
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NATWAY Naturwissenschaften.  (Springer-Verlag, Heidelberger Platz 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.1-    1913-  Volume(issue)/page/year:
   58,578,1971

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - cyanosis
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   32,802,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 640 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 55(6),86,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1140 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodna

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 6400 ug/kg
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,686,1981

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 10 ug/L
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 67,1303,1981

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 2500 ug/L
REFERENCE :
   AETODY Advances in Modern Environmental Toxicology.  (Senate Press, Inc.,
   P.O. Box 252, Princeton Junction, NJ 08550)  V.1-    1980-
   Volume(issue)/page/year: 1,241,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 33 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 5(Suppl
   1),3,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,261,1981

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211,

Restrict 危险品
Storage condition 4

其他信息

  • 用途一:用作浇注型聚氨酯橡胶的硫化剂，也可用于固化环氧树脂
  • MOL 文件:101-14-4.mol
  • MSDS 信息:2,2'-Dichloro-4,4'-methylene dianiline(101-14-4).msds
  • 上游原料:甲醛 --> 2-氯苯胺
  • Sigma Aldrich:101-14-4(sigmaaldrich)
  • 图谱信息:4,4'-二氨基-3,3'-二氯二苯甲烷(101-14-4)红外图谱(IR1) 4,4'-二氨基-3,3'-二氯二苯甲烷(101-14-4)质谱(MS) 4,4'-二氨基-3,3'-二氯二苯甲烷(101-14-4)核磁图( 13 CNMR) 4,4'-二氨基-3,3'-二氯二苯甲烷(101-14-4)红外图谱(IR2)
  • 熔融物比重1.213(107/4℃).溶于稀酸、醚和醇，微溶于水，水溶性<0.1g/100ml at 25℃微有吸收性>
  • TCI Shanghai:4,4'-亚甲基双邻氯苯胺 4,4'-Methylenebis(2-chloroaniline),>;98.0%(T)(101-14-4)
  • 4,4'-二氨基-3,3'-二氯二苯甲烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0609 4,4'-亚甲基双(2-氯苯胺) 4,4'-Methylenebis(2-chloroaniline) 500G 574元 2014/06/02 M0609 4,4'-亚甲基双(2-氯苯胺) 4,4'-Methylenebis(2-chloroaniline) 25G 130元

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. M - Alphabetic
  5. META - METH - M
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Food &amp; Beverage Standards - Chromatography
  5. Food Residue Analysis - Food &amp; Beverage Standards
  6. Food Dyes - Food Residue Analysis
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Method Specific - Analytical Standards
  4. European Community: ISO, DIN and DL 152 - Method Specific
  5. 2002/61/EC - European Community: ISO, DIN and DL 152
  1. Materials Science 材料科学
  2. Products for Polymer Science Research
  3. Monomers - Polymer Science
  4. Amine Monomers - Monomers
  5. Primary Amines - Amine Monomers

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