ATROPINE METHYL NITRATE 甲硝阿托品

CAS 52-88-0 MFCD00050294

化学结构图

52-88-0
SMILES: C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2.O=[N+]([O-])[O-]

化学属性

Mol. FormulaC18H26NO3.NO3
Mol. Weight366.46
Appearance powder
SolubilityH2O: 50 mg/mL
Melting Point163°C

别名和识别编码

Chemical NameATROPINE METHYL NITRATE
Synonym AMN Methylatropine nitrate Harvatrate Atropine methonitrate Eumidrina ATROPINE METHYL NITRATE 甲硝阿托品 ekomine europen harvatrate metropine n-methylatropinenitrate Eumydrin eumydrine Atropine methyl nitrate 1-alpha-h,5-alpha-h-tropanium,3-alpha-hydroxy-8-methyl-,nitrate,(+-)-tropa ,endo-(+/-)-,nitrate(salt) 3-alpha-hydroxy-8-methyl-1-alpha-h,5-alpha-h-tropaniumbromide(+,-)-tropate Ekomine metanite Europen ATROPINE METHONITRATE methylatropinenitrate eumydrin 8-methylatropiniumnitrate dl-hyoscyaminemethylnitrate N-METHYLATROPINIUM NITRATE 甲基硝酸阿托品 dl-hyosyaminemethylnitrate eumidrina Eumydrine 3-alpha-Hydroxy-8-methyl-1-alpha-H,5-alpha-H-tropanium bromide 8-methyl-atropiniunitrate
MDL NumberMFCD00050294
EC Number200-156-1
Chemical Name Translation甲硝阿托品
CAS Number52-88-0
Merck Number875
Wiswesser Line NotationT56 A AKTJ A1 A1 GOVYR&1Q &N-O3
PubChem Substance ID657381
InChIInChI=1S/C18H26NO3.NO3/c1-19(2)14-8-9-15(19)11-16(10-14)22-18(21)17(12-20)13-6-4-3-5-7-13;2-1(3)4/h3-7,14-17,20H,8-12H2,1-2H3;/q+1;-1/t14-,15+,16?,17?;
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安全信息

RTECSCK2800000
WGK Germany3
Hazard Codes Xn
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
UN Number 1544 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1312,1935

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1902 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   1,42,1959

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human
DOSE/DURATION           : 2 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
REFERENCE :
   85IVAW "Possible Long-Term Health Effects of Short-Term Exposure to Chemical
   Agents," National Research Council, 3 vols., Washington, DC, National
   Academy Press, 1982-85  Volume(issue)/page/year: 1,L1,1982

TYPE OF TEST

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 95 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - parasympatholytic
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 137,375,1962

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 20 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 12,346,1961

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
REFERENCE :
   PSYPAG Psychopharmacologia (Berlin).  (Berlin, Ger.)  V.1-46, 1959-76.  For
   publisher information, see PSCHDL.  Volume(issue)/page/year: 10,44,1966

其他信息

  • color:white
  • Sigma Aldrich:52-88-0(sigmaaldrich)
  • MOL 文件:52-88-0.mol

系列性分类

  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Alkaloids

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