Clemizole Hydrochloride 盐酸氯咪唑

CAS 1163-36-6 MFCD00051435

化学结构图

1163-36-6
SMILES: Cl.Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1

化学属性

Mol. FormulaC19 H20 Cl N3 . Cl H
Mol. Weight362.3

别名和识别编码

Chemical NameClemizole Hydrochloride
Synonym 1-(4-Chlorophenyl)methyl)-2-(1-pyrrolidinylmethyl)-(1H)-benzimidazoleHCl 1-(P-CHLOROBENZYL)-2-(1-PYRROLIDINYLMETHYL)-BENZIMIDAZOL 1-(p-Chlorobenzil)-2-pirrolidil-metil-benzimidazolo cloridato 1-(p-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)benzimidazole hydrochloride 1-(p-chlorobenzil)-2-pirrolidil-metil-benzimidazolocloridato 1-(p-chlorobenzyl)-2-(1-pyrrolidinylmethyl)-benzimidazolmonohydrochloride 1-P-CHLOROBENZYL-2-[1-PYRROLIDINYL]-METHYLBENZIMIDAZOLE HYDROCHLORIDE 1-[(4-Chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzoimidazole hydrochloride 1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐 1-p-Chlorobenzyl-pyrrolidyl-methylene-benzimidazole hydrochloride 1-p-chlorobenzyl-pyrrolidyl-methylene-benzimidazolehydrochloride 1-对氯苄基-2-(1-吡咯烷基)甲基苯并咪唑 盐酸盐 Allercur Allercure hydrochloride CLEMIZO
MDL NumberMFCD00051435
PubChem Substance ID5309446
EC Number214-605-4
CAS Number1163-36-6
Chemical Name Translation盐酸氯咪唑
Merck Number2346
Wiswesser Line NotationT56 BN DNJ B1R DG& C1- AT5NTJ &GH
Reaxys-RN3791565
InChIInChI=1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H
LabNetwork Molecule IDLN01326209
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分类

  • {SNA} Antagonists, Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience, Histaminergics, Neuroscience, Neurotransmission, Neurotransmitters

相关文献及参考

  • [2]. Richter JM, et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21
  • [3]. Nishimura T, et al. Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J Pharmacol Exp Ther. 2013 Feb;344(2):388-96.
  • [1]. Einav S, et al. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol. 2008 Sep;26(9):1019-27
  • [1]. Einav S, et al. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol. 2008 Sep;26(9):1019-27
  • [2]. Richter JM, et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21
  • [3]. Nishimura T, et al. Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug in

安全信息

WGK Germany3
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSDD6730000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1950 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 49,18,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 837 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 49,18,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 290 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
   spasmolytic)
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 14,194,1959

TYPE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 74 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 49,18,1960

Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P312
  • P301+P312+P330
  • P301+P317
  • P330 Rinse mouth. 漱口
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Storage condition -20°C 0-10°C

其他信息

  • MOL 文件:1163-36-6.mol
  • 用途一:用作氯咪唑青霉素等药物的中间体

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Histamine Receptor  (组胺受体)
  1. Medical Research Areas
  2. Metabolism
  3. HCV Protease  (HCV蛋白酶)

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