Tetracaine 丁卡因

CAS 94-24-6 MFCD00053787

化学结构图

94-24-6
SMILES: CCCCNc1ccc(C(=O)OCCN(C)C)cc1

化学属性

Mol. FormulaC15H24N2O2
Mol. Weight264
Melting Point41-45

别名和识别编码

Chemical NameTetracaine
CAS Number94-24-6
MDL NumberMFCD00053787
Synonym 2-(Dimethylamino)ethyl 4-(butylamino)benzoate Pontocaine p-(Butylamino)benzoic acid, 2-(dimethylamino)ethyl ester Medicaine TETRACAINE TETRACAINE BASE Rexocaine beta-Dimethylaminoethyl p-butyla Contralgin 2-dimethylaminoethylp-butylaminobenzoate Anetain Amethocaine Intercain Tetracaine Tetrakain 4-(BUTYLAMINO)BENZOIC ACID 2-(DIMETHYLAMINO)ETHYL ESTER Niphanoid Dimethylaminoethyl p-butyl-aminobenzoate p-Butylaminobenzoyl-2-dimethylaminoethanol 2-Dimethylaminoethyl p-butylaminobenzoate Dicaine Dikain LABOTEST-BB LT00772366 {haz Mee 2-(DIMETHYLAMIN
PubChem Substance ID5411
EC Number202-316-6
Reaxys-RN2216051
Chemical Name Translation丁卡因
Beilstein Registry Number2216051
Wiswesser Line Notation4MR DVO2N1&1
LabNetwork Molecule IDLN00241867
InChIInChI=1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
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分类

  • {SNA} Ion Channels, Monovalent Ion Channels, Potassium Channel Modulators, Voltage-gated Ion Channels, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels,
  • {SNA} Core Bioreagents, Enzyme Inhibitors, Pharmacopoeia, Pharmacopoeia A-Z, Pharmacopoeial Antibiotics, Research Essentials, 分析/色谱
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; ester; 1fragment
  • {SNA} Bioactive Small Molecules, Cell Signaling and Neuroscience, Ion Channels, Monovalent Ion Channels, Potassium Channel Modulators, T, Voltage-gated Ion Channels, 细胞生物学

相关文献及参考

  • Short: III/31a Title: Nuclear Quadrupole Resonance Spectroscopy Data: Nuclei D ... Cu Author: Chihara, H.; Nakamura, N. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/31a Year: 1993 Keyword: NQR ISBN: 3-540-55146-8 ISBN: 978-3-540-55146-1 Internet Resource: DOI:10.1007/b43999 RefComment: VIII, 437 pages. Hardcover Abstract: Volume III/31 continues the compilation of nuclear quadrupole resonance spectroscopy data of solid substances which started in with volume III/20 in 1987 covering the literature from the beginning of nuclear quadrupole resonance spectroscopy in 1951 to 1982 and containing the data for 8000 substances in the solid state, distributed among three subvolumes III/20 a, b, and c. Volume III/31 covers the literature published in the period from the end of 1982 through the end of 1989. Included are the data for substances studied for the first time, as well as data for substances already present in the previous volume III/20 if the data published there could be completed or improved by new studies. In total there are 2500 substances in volume III/31, showing the scope and significance of nuclear quadrupole resonance spectroscopy up to recent times.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P301+P310+P330
  • P301+P310
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H351 Suspected of causing cancer 怀疑致癌
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
Signal word
Hazard Codes Xn Xn,Xi
Safety Statements
Risk Statements
  • R42/43
  • R22 Harmful if swallowed 吞咽有害
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
UN Number UN 2811
RTECSDG4725000
Storage condition 0-10 2-8°C 0-10°C
Packing GroupIII
Hazard Class6.1
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intratracheal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KLWOAZ Klinische Wochenscrift.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.1-    1922-  Volume(issue)/page/year:
   31,97,1953

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 6 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 160,53,1931

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 33500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 26,78,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 41500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 7,215,1957

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 1 umol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   14,205,1965

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 30 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

其他信息

  • 类别:有毒物质
  • 毒性分级:高毒
  • 用途一:麻醉用药。
  • 储运特性:库房通风低温干燥; 与食品原料类分开存放
  • MOL 文件:94-24-6.mol
  • 急性毒性:静脉-大鼠 LD50: 6 毫克/公斤; 腹腔-小鼠 LD50: 20 毫克/公斤
  • 可燃性危险特性:热分解排出有毒氮氧化物烟雾
  • 灭火剂:水,干粉、干砂、二氧化碳、泡沫
  • Sigma Aldrich:94-24-6(sigmaaldrich)

系列性分类


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