5-Iodotubercidin 5-碘代杀结核菌素
CAS 24386-93-4 MFCD00055131
化学结构图
SMILES: Nc1ncnc2c1c(I)cn2[C@@H]1O[C@H](CO)[C@H](O)[C@H]1O
化学属性
| Mol. Formula | C11H13IN4O4 |
|---|---|
| Mol. Weight | 392.15 |
| Melting Point | 216-217 |
别名和识别编码
| Chemical Name | 5-Iodotubercidin |
|---|---|
| CAS Number | 24386-93-4 |
| Synonym | 4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine 4-Amino-5-iodo-7-(?-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine 4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine 5-Iodotubericidin 7-Iodo-7-deazaadenosine 4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine 5-Iodotubericidin 7-Iodo-7-deazaadenosine 5'-iodotubericidin 5-Iodotubericidin 5-iodotubercidin 7-Deaza-7-iodoadenosine 7-Iodo-7-deazaadenosine NSC 113939 |
| MDL Number | MFCD00055131 |
| Chemical Name Translation | 5-碘代杀结核菌素 |
| PubChem Substance ID | 97297 |
| LabNetwork Molecule ID | LN01327440 |
| InChI | InChI=1S/C11H13IN4O4/c12-4-1-16(10-6(4)9(13)14-3-15-10)11-8(19)7(18)5(2-17)20-11/h1,3,5,7-8,11,17-19H,2H2,(H2,13,14,15)/t5-,7-,8-,11-/m1/s1 |
| InChIKey | WHSIXKUPQCKWBY-IOSLPCCCSA-N |
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分类
- {SNA} Adenosines/P2 Nucleotide Receptors (Purinergics), Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, I, Neuroscience, Neurotransmission, Neurotransmitters, Others
- {SNA} Adenosines/P2 Nucleotide Receptors (Purinergics), Neuroscience, Neurotransmission, Neurotransmitters, Other Adenosines/P2 Nucleotide Receptors (Purinergics), 细胞信号转导和神经科学, 细胞生物学
- Adenosines/P2 Nucleotide Receptors (Purinergics), Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, I, Neuroscience, Neurotransmission, Neurotransmitters,
产品应用
- An analogue of the antibiotic tubercidin, a pyrrolo[2,3-d]pyrimidine nucleoside antibiotic. A potent inhibitor of adenosine kinase from rat or guinea pig brain. Inhibits uptake of 3H-adenosine into b
相关文献及参考
- [2]. Ugarkar BG, et al. Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues. J Med Chem. 2000 Jul 27;43(15):2883-93.
- [3]. García-Villafranca J, et al. Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase. Biochem Pharmacol. 2002 Jun 1;63(11):1997-2000.
- [4]. De Antoni A, et al. A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B. J Cell Biol. 2012 Oct 15;199(2):269-84.
- [5]. Acharya MM, et al. Adenosine Kinase Inhibition Protects against Cranial Radiation-Induced Cognitive Dysfunction. Front Mol Neurosci. 2016 Jun 3;9:42.
- 1. García-Villafranca, J., and Castro, J., Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase Biochem. Pharmacol. 63 , 1997-2000, (2002) 摘要
- Bonilla-Santiago, R., et al.: Mol. Biochem. Parasitol., 162,
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