Trichlorfon 敌百虫标准溶液
CAS 52-68-6 MFCD00055272
化学结构图
SMILES: COP(=O)(OC)C(O)C(Cl)(Cl)Cl
化学属性
| Mol. Formula | C4H8Cl3O4P |
|---|---|
| Mol. Weight | 257.44 |
| Refractive index | 1.3439 |
| Melting Point | 77-81 |
| Boiling Point | 100 |
| Density | 1.73 |
| Solubility | 略溶于水. 1-5 G/100 ML AT 21 ºC |
别名和识别编码
| Chemical Name | Trichlorfon |
|---|---|
| MDL Number | MFCD00055272 |
| CAS Number | 52-68-6 |
| Synonym | (2,2,2-Trichloro-1-hydr (2,2,2-Trichloro-1-hydroxyethyl)phosphonic acid dimethyl ester 2-三氯-1-羟基乙基）膦酸酯 Agroforotox BAY 15922 BAY-L BAYER L 13/57 Britten Chlorophthalm DEP DIMETHYL (2,2,2-TRICHLORO-1-HYDROXYETHYL)-PHOSPHONATE Dipterex 50 Diptevur Ditrifon Fliegenteller Foschlor R Foschlor R-50 Metrifonate Metriphonate O,O-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate Vermicide bayer 2349 dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate o,o-dimethyl-2,2,2-trichloro-1-hydroxy-eth {} {} { {} {} {uni_hambu {} {} {uni_hamburg} 三氯松 敌百虫可溶性粉剂 甲基一六○五乳剂 |
| PubChem Substance ID | 5853 |
| Beilstein Registry Number | 1709434 |
| EC Number | 200-149-3 |
| Chemical Name Translation | 敌百虫标准溶液 |
| Merck Number | 13,9696 |
| Wiswesser Line Notation | GXGGYQPO&O1&O1 |
| InChI | InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3 |
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分类
- {SA} Acaricides, Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antiparasitic / Antiprotozoal / Anthelminthic, Chromatography, Environmental Standards, Insecticides, Organophorous, Pesticides, Pesticides & Metabolites, Q-Z, Spectrum of Activity, T, TP - TZ
- {SNA} Acaricides, All alphabetically sorted, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Antibiotics,
- {SNA} Acaricides,
- {Chemicalbook} 农药: 杀虫（螨）剂: 有机磷杀虫剂
产品应用
- 兼有胃毒和触杀作用的广谱性杀虫剂。农药残留量分析标准。
- 校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。
相关文献及参考
- Short: III/20a
- Short: EINECS
- Merck: 14,9623
- Short: III/10a
- Short: IV/8A
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P302+P352+P312
- P304+P340
- P342+P311
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H302 Harmful if swallowed 吞食有害
- S24 Avoid contact with skin 避免皮肤接触；
- S37 Wear suitable gloves 戴适当手套；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- R22 Harmful if swallowed 吞咽有害
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
- R50/53
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 183 mg/kg/6W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - tumors REFERENCE : ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949- Volume(issue)/page/year: 41,311,1973
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 186 mg/kg/6W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - tumors REFERENCE : ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949- Volume(issue)/page/year: 41,311,1973
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1950 mg/kg/22W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors REFERENCE : ERNFA7 Ernaehrungsforschung. (Akademie-Verlag GmbH, Leipziger St. 3-4, 108 Berlin, Ger. Dem. Rep.) V.1- 1956- Volume(issue)/page/year: 16,515,1972
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 420 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase REFERE
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Cardiac - other changes Liver - other changes Blood - hemorrhage REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 41,3,1978
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Vascular - other changes Lungs, Thorax, or Respiration - other changes Blood - hemorrhage REFERENCE : MDWTAG Medycyna Weterynaryjna. Veterinary Medicine. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1945- Volume(issue)/page/year: 35,479,1979
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >1500 mg/kg TOXIC EFFECTS : Skin and Appendages - dermatitis, irritative (after systemic exposure) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 8(10),54,1964
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 20 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 300,135,1993
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 5000 ppm REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB80-133226
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 20 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 88,307,1981
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 20 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 300,135,1993
TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Human Cells - not otherwise specified DOSE/DURATION : 4 mol/L REFERENCE : PSSCBG Pesticide Science. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1970- Volume(issue)/page/year: 15,439,1984
TYPE OF TEST : Dominant lethal test ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 405 mg/kg REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/pag
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - guinea pig DOSE : 375 mg/kg SEX/DURATION : female 42-44 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System REFERENCE : NEREDZ Neurochemical Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1976- Volume(issue)/page/year: 19,569,1994
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 78400 ug/kg SEX/DURATION : female 16-22 day(s) after c
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE : 2 gm/kg SEX/DURATION : female 7-11 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) REFERENCE : EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 30,105,1979
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE : 600 mg/kg SEX/DURATION : female 36-53 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 59,30,1986
其他信息
- RTECS号:TA0700000
- MOL 文件:52-68-6.mol
- 生产方法:首先使甲醇与三氯乙醛混合生成半缩醛（并含少量缩醛）。 然后在较低温度下，三氯化磷与甲醇反应生成亚磷酸二甲酯（游离甲醇或半缩醛及缩醛中的甲醇都极易与三氯化磷反应），及时排除HCl和CH3Cl。 最后，在较高的温度下，三氯乙醛与亚磷酸二甲酯发生缩合反应，生成敌百虫。 在连续操作中控制甲醇和三氯乙醛略大于理论量，质量比为三氯化磷；甲醇；三氯乙醛=1:(0.73～0.78):(1.12～1.18)；酯化温度为40～50℃，停留时间10min；脱酸液的液相温度80℃，缩合温度90～95℃，停留时间40～50min；脱回流液温度先95～105℃，后<;120℃。 敌百虫生产也可采用一步合成分段进行的办法。即一次投料，在低温下生成亚磷酸二甲酯，不经分离，在高温下直接生成敌百虫。酯化阶段三氯乙醛和甲醇混合，温度不超过50℃，冷却至5℃以下，加入三氯化磷，排出氯化氢和氯甲烷回收处理。缩合阶段酯化液经甩敌国进一步脱出氯化氢后，进行反应罐，温度80～120℃，即生成敌百虫。
- 毒害物质数据:52-68-6(Hazardous Substances Data)
- 毒性:雄性大鼠急性经口LD 50 为630mg/kg，雌性为560mg/kg；大鼠急性经皮LD 50 >2000mg/kg。含500mg/kg饲料喂养大鼠2年，未发现异常现象。
- EPA化学物质信息:Phosphonic acid, (2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester(52-68-6)
- 在中性和弱溶液中比较稳定，但其溶液长期放置会变质，在碱性溶液转化成敌敌畏，转化过程随着碱性增强和温度升高而加速，加热至180℃分解。20℃时水中溶解度15.4g/100ml。溶于苯、乙醇和多数氯化烃，微溶于乙醚、四氯化碳，不溶于甘油。低毒，半数致死量（雄大鼠，经口）630mg/kg。对金属有腐蚀性。
- HazardClass:6.1(b)
- 有令人愉快的气味。在中性和弱溶液中比较稳定，但其溶液长期放置会变质，在碱性溶液转化成敌敌畏，转化过程随着碱性增强和温度升高而加速，加热至180℃分解。20℃时水中溶解度15.4g/100ml。溶于苯、乙醇和多数氯化烃，微溶于乙醚、四氯化碳，不溶于甘油。低毒，半数致死量（雄大鼠，经口）630mg/kg。对金属有腐蚀性。
- PackingGroup:III
- 外观性质:纯品为白色结晶，有醛类气味。
- 用途:主要用于防治蔬菜、果树、茶、桑、棉花和粮食作物上的各种害虫，亦可作卫生用药和防治牲畜寄生虫
- NIST化学物质信息:Metrifonate(52-68-6)
- 图谱信息:O,O-二甲基-(2,2,2-三氯-1-羟基乙基)磷酸酯(52-68-6)质谱(MS) O,O-二甲基-(2,2,2-三氯-1-羟基乙基)磷酸酯(52-68-6)核磁图( 1 HNMR) O,O-二甲基-(2,2,2-三氯-1-羟基乙基)磷酸酯(52-68-6)核磁图( 13 CNMR)
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