Molinate 禾草敌

CAS 2212-67-1 MFCD00055352

化学结构图

2212-67-1
SMILES: CCSC(=O)N1CCCCCC1

化学属性

Mol. FormulaC9H17NOS
Mol. Weight187.30
Boiling Point202°C
Density1.0
Solubility0.08 G/100 ML
Flash Point100 °C
Appearance D Pa,蒸气压7.466×10 20 1.5124。能溶于丙酮、甲醇、异丙醇、苯、二甲苯,水中溶解度0.8g/L (20℃)。水田中半衰期为21~25d,受土壤微生物作用,分解出氨及二氧化碳。对热稳定,无腐蚀性,但用药时不宜使用聚氯乙烯管道或容器。℃ Pa (25℃),相对密度1.065,折射率n 本水为黄褐色透明油状液体。b.p.202℃/1.33×10 -1 3
Refractive index1.5124

别名和识别编码

Chemical NameMolinate
MDL NumberMFCD00055352
CAS Number2212-67-1
Beilstein Registry Number1239196
EC Number218-661-0
Synonym 1H-Azepine-1 carbothioic acid hexahydro-S-ethyl ester; Ethyl 1-hexamethyleneiminecarbothioate 1h-azepine-1 carbothioic acid hexahydro-s-ethyl ester ETHYL-1-HEXAMETHYLENE IMINE CARBOTHIOLATE Ethyl 1-hexamethyleneiminecarbothioate Ethyl 1-hexamethyleneiminecarbothiolate Felan HYDRAM Hydram Ialan Jalan MOLINAT MOLINATE Molinate Molinate estrella Molinate granules Molmate Morinate granules N,N-六亚甲基硫代氨基甲酸-S-乙酯 N,N-六亚甲基硫羟氨基甲酸酯 N,N-六亚甲基硫赶氨基甲酸乙酯 N,N-六亚甲基赶氨基甲酸乙酯 N-大亚甲基硫代氨基甲酸酯 ORDRAM ORDRAM(R) Ordram Ordram granules R-4572 S-Aethyl-N-hexahydro-1H-azepinthiolcarbamat S-ETH
Chemical Name Translation禾草敌
Wiswesser Line NotationT7NTJ AVS2
PubChem Substance ID16653
InChIInChI=1S/C9H17NOS/c1-2-12-9(11)10-7-5-3-4-6-8-10/h2-8H2,1H3
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分类

  • {SNA} 2005/48/EU, Alphabetical Index of Analytical Standards, Method and Regulation Specific, All alphabetically sorted, Analytical Standards, Analytical/Chromatography, Chromatography, Environmental Standards, European Community: ISO, DIN and DL 152, H-M,
  • {SA} 2005/48/EU, Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, Environmental Standards, European Community: ISO, DIN and DL 152, H-M, Herbicides, M, METI - MZ, Method Specific, Pesticides & Metabolites, Thiocarbamates
  • {SNA} 2005/48/EU,

产品应用

  • 草达灭是直播稻的主要除草剂,其除草作用是由于阴止蛋白质的转化,使增殖的细胞得不到原生质,而只有细胞壁的空细胞使新叶不能生长,生长点呈扭曲状,终致爆裂死亡。用于水稻田防除稗草,对大稗有特效。

安全信息

RTECSCM2625000
GHS Symbol
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P203
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P301+P317
  • P302+P352
  • P304+P312
  • P304+P340
  • P304+P340+P312
  • P305+P351+P338
  • P307+P311
  • P308+P313
  • P308+P316
  • P309+P311
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P317
  • P318
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P333+P313
  • P337+P313
  • P337+P317
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H302+H332
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H332 Harmful if inhaled 吸入有害
  • H351 Suspected of causing cancer 怀疑致癌
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
WGK Germany3
Signal word Warning
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes T,N,Xn Xn,N
Risk Statements
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
  • R48/22
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R50/53
Safety Statements
  • S46 If swallowed, seek medical advice immediately and show this container or label 食入时,立即求医并出示容器/标签;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
Packing GroupIII
Hazard Class6.1(b)
Storage condition 0-6°C
UN Number 2902
Warnings 危化品目录(2015) 危险化学品
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 657 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 40(10),104,1975

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : >200 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 35(8),35,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 369 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PEMNDP Pesticide Manual.  (The British Crop Protection Council, 20 Bridport
   Rd., Thornton Heath CR4 7QG, UK)  V.1-    1968-  Volume(issue)/page/year:
   9,594,1991

TYPE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 3536 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMCHA2 Farm Chemicals Handbook.  (Meister Pub., 37841 Euclid Ave.,
   Willoughy, OH 44094)  Volume(issue)/page/year: -,C208,1991

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 350 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 242,279,1990

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 20 ug/L
REFERENCE :
   CYGEDX Cytology and Genetics (English Translation).  Translation of TGANAK.
   (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011)  V.8-    1974-
   Volume(issue)/page/year: 11(4),62,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1620 mg/kg
SEX/DURATION            : male 90 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 38,90,1975

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 640 ug/m3/6H
SEX/DURATION            : male 20 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 324 mg/kg
SEX/DURATION            : male 90 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 38,90,1975

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其他信息

  • 中毒症状:对眼睛、皮肤和呼吸道有刺激,摄入量大时对胆碱酯酶有轻度刺激。
  • 可燃性危险特性:燃烧产生有毒氮氧化物和硫氧化物气体
  • 用途三:草达灭是直播稻的主要除草剂,其除草作用是由于阴止蛋白质的转化,使增殖的细胞得不到原生质,而只有细胞壁的空细胞使新叶不能生长,生长点呈扭曲状,终致爆裂死亡。用于水稻田防除稗草,对大稗有特效。
  • Sigma Aldrich:2212-67-1(sigmaaldrich)
  • 类别:农药
  • 毒性分级:高毒
  • 上游原料:二氧化碳 --> 硅藻土 --> 甲酸钠 --> 1,6-己内酰胺 --> 乙硫醇 --> 硫酸二乙酯 --> 羰基硫 --> 硫醇 --> 环戊烷 --> 氯甲酸薄荷酯 --> 加氢催化剂 --> 六亚甲基亚胺 --> 硫代氯甲酸乙酯
  • 用途一:可防治萌发的阔叶及禾本科杂草
  • 用途二:防除水稻稗草的选择性除草剂。药剂通过杂草芽鞘和初生根被吸收,抑制α-淀粉酶活性,阻止蛋白质转化,从而使增殖细胞得不到原生质,新叶不能生长,致使杂草死亡。环草丹专除水稻田1~4叶期的各种生态型稗草,用药15~35g有效成分/100m 2 ,持效期30~40d。如在苗期使用,当秧田或直播田的苗长到3叶以上,田间稗草2~3叶期时,用禾大壮乳油15~22.5mL对水喷雾或制成毒土撒施,田间水层3cm左右,并保持5~7d,也可在播前或移栽本田使用。
  • 方法一:氯甲酸友谊赶乙酯的制备 在冷却条件下,于20~30℃将光气通入到乙硫醇和催化剂混合液中,然后反应混合物在没有外部冷却的情况下(保持干冰冷凝器)继续搅拌几小时,反应结束后用空气于20~30℃将过量光气驱除,反应混合物用4.5%盐酸和水洗涤,硫酸镁干燥,过滤,滤液真空回流除去挥发性杂质,回流冷凝中冷却水维持在氯甲酸硫赶乙酯能冷凝而硫醇不冷凝的温度,被蒸馏物温度保持恒定10min,停止回流。 六次甲基亚胺的制备 在氢气和己内酰胺混合物露点以上温度形成蒸气混合物,并将该蒸气混合物通过240~270℃的加氢催化剂(预先需用脂肪族或脂环族烃C5~C6处理),配比为氢:己内酰胺=(10~100):1 (mol),压力5×10 5 ~10×10 5 Pa,己内酰胺转化率为80%~100%,以转化的己内酰胺计,产率为97%~98%。 实例:将11.0标准m 3 /h氢和0.8kg/h己内酰胺加入到蒸发器中,蒸气混合物温度维持在240℃,即比生成的蒸气混合物露点高40℃,该混合物通入含3.5L Cu-Zn催化剂 (Cu 40%、Zn 8%/硅藻土)的反应器(通入上述蒸气混合物前,将1.3kg环戊烷蒸气先通过反应器)。加氢过程于240℃、10×10 5 Pa下进行,己内酰胺转化率100%,六次甲基亚胺产率为98%。 禾草敌的合成 将含14g (0.35mol)氢氧化钠的200mL水溶液与31.7g (0.32mol)六次甲基亚胺的100mL正戊烷混合后,在冷却下,将37.4g (0.30mol)氯甲酸硫赶乙酯加入到剧烈
  • 用途四:是直播稻的主要除草剂,其除草作用是由于阴止蛋白质的转化,使增殖的细胞得不到原生质,而只有细胞壁的空细胞使新叶不能生长,生长点呈扭曲状,终致爆裂死亡。用于水稻田防除稗草,对大稗有特效。校准仪器和装置;评价方法;工作标准;质量保证/质量控制;其他。
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 注意事项:[1]禾草特挥发性很强,因此拌药要均匀并与土、砂、肥应随拌随施,施药后 应用塑料布严密覆盖。一定要按要求保持水层,漏水田或整地不平的田块,均会降低效果。 [2]剩余的药剂应密封保存在阴凉干燥,远离食品、饲料 、种子、火源及儿童接触不到的地方,施药时应注意安全防护措施,避免污染皮肤和眼腈
  • 方法二:有光气法和氧硫化碳法。1.光气法 将气与六甲撑亚胺反应生成六甲撑甲酰氯,进而在过量碱存在下与乙硫醇进行巯基化反应而得。亦可将光气先与乙硫醇反应生成S-乙基硫代氯甲酸酯,再与六甲撑亚胺反应而得。2.氧硫化碳法 氧硫化碳在碱作用下与六甲撑亚胺反应,生成N,N-六甲撑硫化氨基甲酸钠,再与硫酸二乙酯或其他乙基化剂反应而得。
  • 毒性:雄性大鼠急性经口LD 50 为501~720mg/kg (原药为468~705mg/k

系列性分类


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