Testosterone Enanthate 庚酸睾酮

CAS 315-37-7 MFCD00055890

化学结构图

315-37-7
SMILES: CCCCCCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

化学属性

Mol. FormulaC26H40O3
Mol. Weight400.66
Melting Point34-39 ºC
Appearance 白色结晶性粉末。熔点为34-36℃。
Density
Boiling Point

别名和识别编码

Chemical NameTestosterone Enanthate
Synonym 17-Hydroxyandrost-4-en-3-one, 17-heptanoate 17-[(1-Oxoheptyl)oxy]androst-4-en-3-one 17BETA-HYDROXY-4-ANDROSTEN-3-ONE 17-ENANTHATE 17b-hydroxyandrost-4-en-3-one-17-ethanate 3-Oxoandrost-4-en-17-yl heptanoate 4-ANDROSTEN-17-BETA-OL-3-ONE ENANTHATE 4-ANDROSTEN-17BETA-OL-3-ONE 17-ENANTHATE Andro L.A. 200 Androst-4-en-3-one, 17-((1-oxoheptyl)oxy)-, (17-beta)- Androst-4-en-3-one, 17-[(1-oxoheptyl)oxy]-, (17beta)- Androst-4-en-3-one, 17beta-hydroxy-, heptanoate Androtardyl Atlatest Delatestryl Heptanoic acid, ester with testosterone Malogen L.A.200 NSC-17591 Reposo TMD TESTOSTERONE ENANTATE TESTOSTERONE ENANTHATE TESTOSTERONE HEPTANOATE TESTOSTERONE HEPTYLATE Testenate Testosterone 17-enanthate Testosterone enanthate Testosterone heptanoate; 17b-Hydroxyandrost-4-en-3-one-17-ethanate Testosterone heptylate Testosterone oenanthate component of Androgyn l.a. component of Deladumone component of Ditate component of Mal-O-Fem L.A 庚酸睾丸素 庚酸睾酮 睾丸激素庚酸酯 睾酮庚酸酯
MDL NumberMFCD00055890
PubChem Substance ID9416
EC Number206-253-5
CAS Number315-37-7
Chemical Name Translation庚酸睾酮
Wiswesser Line NotationL E5 B666 OV MUTJ A E FOV6
Beilstein Registry Number3170544
InChIInChI=1S/C26H40O3/c1-4-5-6-7-8-24(28)29-23-12-11-21-20-10-9-18-17-19(27)13-15-25(18,2)22(20)14-16-26(21,23)3/h17,20-23H,4-16H2,1-3H3/t20-,21-,22-,23-,25-,26-/m0/s1
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分类

  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, Neat Compounds, Steroid, T, TA - TE

安全信息

RTECSXA3080000
GHS Symbol
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P308 IF exposed or concerned: 如果接触或涉及
Hazard statements
  • H350 May cause cancer 可能致癌
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
Signal word Danger
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Hazard Codes T
Risk Statements
  • R45 May cause cancer 可能致癌
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
Storage condition 2-8°C 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 409 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - other reproductive system tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   26,474,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1770 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,805,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 755 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Ja

{hazard_c

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,805,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,805,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,805,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - man
DOSE                    : 20 mg/kg
SEX/DURATION            :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 630 mg/kg
SEX/DURATION            : male 21 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   67,131,1993

{hazard_c

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 35455 ug/kg
SEX/DURATION            : female 4-14 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   THGNBO Theriogenology.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1974-  Volume(issue)/page/year: 6,21,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 36 mg/kg
SEX/DURATION            : male 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   ANENAG Annales d'Endocrinologie.  (Masson Editeur, 120 Blvd. Saint-Germain,
   F-25280 Paris Cedex 06, France)  V.1-    1939-  Volume(issue)/page/year:
   17,118,1956

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Ma

UN Number
Packing Group

其他信息

  • 雄性激素类药物:庚酸睾酮 为雄性激素类药物，是睾酮丙酸酯与睾酮庚酸酯的复合制剂。作用与丙酮睾酮相同，能促进男性性器官及副性征的发育，对抗雌激素。还有蛋白同化作用，可使肌肉增长、体重增加等。作用快，且持续时间较长，注射250mg可维持药效2～4周。临床上适用于治疗男性性腺机能不全、性器官发育不良、不育症、无睾症和稳睾症等;也可用于女性功能性子宫出血、更年期综合征、乳腺癌和性器官癌;肝硬化、再生障碍性贫血、骨质疏松症等;消耗性疾病。 【不良反应】大剂量或长期使用，可引起水钠潴留和水肿现象。青年女性可出现男性化现象，如嗓音变粗、多毛、痤疮、阴蒂肥大等。前列腺癌、孕妇禁用。前列腺肥大及肝、肾功能障碍者慎用庚酸睾酮。治疗乳腺癌时，如发现血钙过高应立即停药。
  • 男性避孕药:庚酸睾酮即是一种激素酯，它能抑制脑垂体，促进性腺素释放，从而使睾丸间质细胞分泌的内源睾酮下降，最终达到阻断精子发生的目的。中科院动物所在对猴子进行试验时发现，每周注射１次庚酸睾酮，一周后猴子的精细胞开始凋亡，到第五周精细胞凋亡达到高峰。对308位志愿者的临床试验还表明，庚酸睾酮避孕药对亚洲男性的作用明显高于白种人。在这项研究中，虽然精子的减少率并未呈现种族间的差异，但亚洲人比白种人对激素导致的精子发生抑制更为敏感，９５％以上的亚洲人可达到无精子，而只有40%至70%的白种人成为无精子。 庚酸睾酮是一种长效男性避孕药，可通过多种途径给药(每周2次至每3周1次，每次200～500mg，肌内注射) ，通过对100余例志愿者试用，结果表明，每周肌内注射250mg，10周后可使大多数男子产生无精子症或严重少精子症，停药一定时间后精子数均可恢复，不良反应同前。如将注射间隔延长至10～12d以上，用加倍剂量效果也不理想。药代动力学研究表明，本品注射后当即产生一个超生理水平的血高峰，此后血浓度迅速下降，说明每周给药的必要; 此项血高峰有可能直接刺激生精，故部分志愿者未能达到明显少精子症，少数志愿者精子密度下降后可再次上升。庚酸睾酮只需每周注射1次，似比丙酸睾酮优越; 但即使如此，也甚难为多数人所接受。其他两种睾酮制剂，即环戊丙酸睾酮及环己烷羧酸睾酮，亦需每周注射1次。
  • Sigma Aldrich:315-37-7(sigmaaldrich)
  • 比旋光度:77 °
  • 用途一:临床用于治疗男性性机能减退，再生障碍性贫血等病症
  • 用途二:临床用于男性机能减退，再生障碍性贫血等。
  • MOL 文件:315-37-7.mol

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs & Metabolites - Forensic and Veterinary Standards
  6. Neat Compounds - Drugs & Metabolites
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. T - Alphabetic
  5. TA - TE - T

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