Flumethasone 氟米松

CAS 2135-17-3 MFCD00056464

化学结构图

2135-17-3
SMILES: C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

化学属性

Mol. FormulaC22H28F2O5
Mol. Weight410
SolubilityDMSO 82 mg/mL Water <1 mg/mL Ethanol 6 mg/mL

别名和识别编码

Chemical NameFlumethasone
CAS Number2135-17-3
Synonym ######## 1,4-PREGNADIEN-6-ALPHA, 9-ALPHA-DIFLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 6A-FLUORO-DEXAMETHASONE 6ALPHA,9ALPHA-DIFLUORO-16ALPHA-METHYLPREDNISOLONE 6a,9a-difluoro-16a-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione 6a,9a-difluoro-16a-methylprednisolone 6Α-氟地塞米松 6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 6α,9α-Difluoro-16α-methylprednisolone 6α-Fluorodexamethasone ANIPRIME Anaprime Aniprime FLUCORT FLUMETHASONE Flumethasone Fluorodexamethasone RS-2177 U-10974 flucorticin flumethason fluvet ha-methyl- methagon rs-2177 氟米松; 双氟美松 福如迈塔松
MDL NumberMFCD00056464
PubChem Substance ID16490
EC Number218-370-9
Chemical Name Translation氟米松
Wiswesser Line NotationL E5 B666 OV AHTTT&J A1 BF CQ E1 FV1 FQ G1 LF
Beilstein Registry Number5645455
LabNetwork Molecule IDLN01307226
InChIInChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Steroids,
  • {SNA} Antibiotics, Antibiotics A to Z, Antibiotics A-F

产品应用

  • A glucocorticoid. An anti-inflammatory.

相关文献及参考

  • Matuszewski, B, et al.: Anal. Chem., 75, 3019 (2003),
  • Fekete, S., et al.: J. Pharm. Biomed. Anal., 49, 64 (2009),

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P203
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P308+P313
  • P318
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
RTECSTU3832000
Signal word
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes Xn
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
Storage condition 储存温度 2-8℃ 储存温度-20°C 2-8°C 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - cattle
DOSE                    : 30 ug/kg
SEX/DURATION            : female 31 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   JAVMA4 Journal of the American Veterinary Medical Association.  (American
   Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196)  V.48-
   1915-  Volume(issue)/page/year: 160,867,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - cattle
DOSE                    : 20 ug/kg
SEX/DURATION            : female 38 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 28,407,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - cattle
DOSE                    : 20 ug/kg
SEX/DURATION            : female 40 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
REFERENCE :
   THGNBO Theriogenology.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1974-  Volume(issue)/page/year: 20,267,1983

其他信息

  • Flumethasone是一种糖皮质激素受体激动剂，该复合物结合到核中，造成各种基因激活和抑制。
  • Flumethasone
  • MOL 文件:2135-17-3.mol
  • Sigma Aldrich:2135-17-3(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics A-F - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics A-F - Antibiotics A to Z

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