Oxolinic acid 噁喹酸

CAS 14698-29-4 MFCD00056775

化学结构图

14698-29-4
SMILES: CCN1C=C(C(=O)C2=CC3OCOC=3C=C12)C(O)=O

化学属性

Mol. FormulaC13H11NO5
Mol. Weight261
Boiling Point473
Melting Point314-316

别名和识别编码

Chemical NameOxolinic acid
CAS Number14698-29-4
Synonym W 4565 Gramurin Urotrate Uro-alvar NSC-110364 5,8-Dihydro-5-ethyl-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid Ossian Starner Uroxol Oxoboi Pietil Emyrenil 1-Ethyl-1,4-dihydro-6,7-methylenedioxy-4-oxo-3-quinolinecarboxylic acid Ultibid Prodoxol Oxolinic acid
MDL NumberMFCD00056775
PubChem Substance ID24278604
Beilstein Registry Number620635
EC Number238-750-8
Chemical Name Translation噁喹酸
Wiswesser Line NotationT C566 DO FO JN MV EHJ J2 LVQ
LabNetwork Molecule IDLN00198127
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分类

  • 1694 Pharmaceuticals & Personal Care Products, Analytical Standards, Analytical/Chromatography, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Bactericides, Chemical Structure Class, Chromatography, EPA, Environmental Standards, Inhibits an Enzyme, Interferes with DNA Synthesis, L - Z, Mechanism of Action, Method Specific, Neats, Pesticides, Pesticides & Metabolites, Quinolones and Fluoroquinolones, Spectrum of Activity
  • {SNA} 1694 Pharmaceuticals & Personal Care Products, Analytical Standards, Analytical/Chromatography,
  • {SNA} Antibacterial,

产品应用

  • Quinolone antibacterial.

相关文献及参考

  • DiCarlo, et al.: Arch. Biochem. Biophys., 127, 503 (1968),
  • Crew, et al.: Xenobiotica, 1, 193 (1971),
  • Wright, H.T., et al.: Science, 213, 455 (1981),
  • 1. J S Thompson, Colistin-oxolinic acid blood agar: a selective medium for the isolation of Gardnerella vaginalis . J. Clin. Microbiol. 21 , 843, (1985) 摘要
  • Garcia de Mateos-Verchere J, et al., Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor Eur. Neuropsychopharmacol. 8 , 255-259, (1998) 摘要
  • Merck 14 ,6945

安全信息

RTECSJI5075000
WGK Germany3
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Hazard Codes Xn
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 43800 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   32,397,1994

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 525 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1890 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 177 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4292317

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPIFAN Japan Pesticide Information.  (Japan Plant Protection Assoc.,
   1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan)  No.1-61, 1969-92.  For
   publisher information, see AGJAEP.  Volume(issue)/page/year: (55),21,1989

{ha

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 248,135,1991

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 243,213,1990

{haz

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 600 ug/L
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 37,213,1993

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 248,135,1991

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 130 ug/L
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiolo

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 mg/L
REFERENCE :
   EJBCAI European Journal of Biochemistry.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1967-
   Volume(issue)/page/year: 62,491,1976

TYPE

系列性分类


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