7,10-Dimethylbenz(c)acridine 7,10-二甲基苯并[c]吖啶

CAS 2381-40-0 MFCD00056821

化学结构图

2381-40-0
SMILES: Cc1ccc2c(C)c3ccc4ccccc4c3nc2c1

化学属性

Mol. FormulaC19H15N
Mol. Weight257.33
Melting Point147-149 °C(lit.)

别名和识别编码

Chemical Name7,10-Dimethylbenz(c)acridine
MDL NumberMFCD00056821
PubChem Substance ID16936
Synonym 7,10-Dimethylbenzo[c]acridine {LY} 7,10-Dimethylbenzo[c]acridine {} {LY} 7,10-Dimethylbenzo[c]acridine {} {} {LY} 7,10-Dimethylbenzo[c]acridine {} {} {} {LY} 7,10-Dimethylbenzo[c]acridine {} {} {} {} {LY} 7,10-Dimethylbenzo[c]acridine {} {} {} {} {} {LY} 7,10-Dimethylbenzo[c]acridine {} {} {} {} {} {} {LY} 7,10-Dimethylbenzo[c]acridine {} {} {} {} {} {} {} {LY} 7,10-Dimethylbenzo[c]acridine {} {} {} {} {} {} {} {} {LY} 7,10-Dimethylbenzo[c]acridine {} {} {} {} {} {} {} {} {} {LY} 7,10-Dimethylbenzo[c]acridine {} {} {} {} {} {} {} {} {} {} {LY} 7,10-Dimethylbenzo[c]acridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7,10-Dimethylbenzo[c]acridine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7,10-Dimethylbenzo[c]acridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7,10-Dimethylbenzo[c]acridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7,10-Dimethylbenzo[c]
Wiswesser Line NotationT D6 B666 CNJ F J
CAS Number2381-40-0
Beilstein Registry Number0192194
InChIKeyRCWNHXIFXQTICS-UHFFFAOYSA-N
InChIInChI=1S/C19H15N/c1-12-7-9-15-13(2)16-10-8-14-5-3-4-6-17(14)19(16)20-18(15)11-12/h3-11H,1-2H3
Chemical Name Translation 7,10-二甲基苯并[c]吖啶
Canonical SMILESCC1=CC2=NC3=C(C=CC4=CC=CC=C43)C(=C2C=C1)C
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分类

  • {SNA} Acridines, Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks

安全信息

RTECSCU3485000
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H315 Causes skin irritation 会刺激皮肤
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H351 Suspected of causing cancer 怀疑致癌
  • H319 Causes serious eye irritation 严重刺激眼睛
WGK Germany3
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S22 Do not breathe dust 不要吸入粉尘;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg/10D-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   BAFEAG Bulletin de l'Association Francaise pour l'Etude du Cancer.  (Paris,
   France)  V.1-52, 1908-65. For publisher information, see BUCABS.
   Volume(issue)/page/year: 34,22,1947

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 190 mg/kg/16W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Lungs, Thorax, or Respiration - bronchiolar constriction
REFERENCE :
   ACRSAJ Advances in Cancer Research.  (Academic Press, Inc., 465 S. Lincoln
   Dr., Troy, MO 63379) V.1-    1953-  Volume(issue)/page/year: 4,315,1956

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg/4W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   ACRSAJ Advances in Cancer Research.  (Academic Press, Inc., 465 S. Lincoln
   Dr., Troy, MO 63379) V.1-    1953-  Volume(issue)/page/year: 4,315,1956

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 2 mg/L
REFERENCE :
   EJCAAH European Journal of Cancer.  (Oxford, UK)  V.1-17(6), 1965-1981. For
   publisher information, see EJCODS.  Volume(issue)/page/year: 17,179,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 ug/plate
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 72,5135,1975

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Kidney
DOSE/DURATION           : 80 ug/L
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   37,873,1978

Storage condition

系列性分类


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