Harringtonin

CAS 26833-85-2 MFCD00056888

化学结构图

26833-85-2
SMILES: CC(C)(O)CCC(O)(CC(=O)OC)C(=O)O[C@@H]1C2C3=CC4OCOC=4C=C3CCN3CCC[C@]32C=C1OC

化学属性

Mol. FormulaC28H37NO9
Mol. Weight532
Melting Point73-75

别名和识别编码

Chemical NameCephalotaxine, 4-methyl-,2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate(ester), (3(R))-
CAS Number26833-85-2
Synonym 3-[4-Methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate]cephalotaxine Alkaloid C from cephalotaxus Harringtonin NSC 124147
Wiswesser Line NotationT5 H5 F675 1A T AX IO KO QN BU JHT&&TTJ CO1DOVXQ1VQ2XQ1&1 T1
Chemical Name Translation
MDL Number
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • A natural product with significant antitumor activities.

相关文献及参考

  • Sah, N., et al.: J. Biol. Chem., 278, 20593 (2003),
  • Lu, D., et al.: J. Int. Med. Res., 32, 488 (2004),
  • Yunmbam, M., et al.: Oncol. Rep., 11, 833 (2004),

安全信息

RTECSFK0250000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOETD7 Journal of Ethnopharmacology.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1979-  Volume(issue)/page/year:
   24,1,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4170 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CMJODS Chinese Medical Journal (Beijing, English Edition).  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 
     1975-    Adopted vol. no. 92 in 1979.  Volume(issue)/page/year:
   92,175,1979

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 200 ug/L
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   7,173,1986

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 10 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 301,223,1993

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1250 ug/kg
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   7,173,1986

GHS Symbol
UN Number 2811
Hazard Codes 6.1
Signal word Danger
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Packing GroupII

系列性分类

  1. Functional Group 官能团索引
  2. enol ether

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