2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic acid 2-(4-(1-氧代异吲哚啉-2-基)苯基)丙酸
CAS 31842-01-0 MFCD00057144
化学结构图
SMILES: CC(C(O)=O)C1C=CC(=CC=1)N1CC2C=CC=CC=2C1=O
化学属性
| Mol. Formula | C17H15NO3 |
|---|---|
| Mol. Weight | 281 |
别名和识别编码
| Chemical Name | 2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic acid |
|---|---|
| CAS Number | 31842-01-0 |
| Synonym | Indoprofen Propionic acid, alpha-(4-(1-oxo-2-isoindolinyl)phenyl)- Flosin Reumofene 2-(4-(1-Carboxyethyl)phenyl)-1-isoindolinone K 4277 Propionic acid, 2-(p-(1-oxo-2-isoindolinyl)phenyl)- 4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-alpha-methylbenzeneacetic acid 吲哚洛芬 Isindone alpha-(4-(1-Oxo-2-iso-indolinyl)-phenyl)-propionic acid ######## Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-alpha-methyl- 1-Oxo-2-(p-((alpha-methyl)carboxymethyl)phenyl)isoindoline Flosint α-Methyl-p-(1-oxo-2-isoindolinyl)benzeneacetic acid p-(1-Oxo-2-isoindolinyl)-hydratropic acid |
| MDL Number | MFCD00057144 |
| PubChem Substance ID | 24896022 |
| EC Number | 250-833-0 |
| Chemical Name Translation | 2-(4-(1-氧代异吲哚啉-2-基)苯基)丙酸 |
| Wiswesser Line Notation | T56 BVN DHJ CR DY1&VQ |
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分类
- {SNA} Additional Drugs, Additional Standards, Analytical Standards, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds, Pharmaceuticals, Illicit Drugs & Alcohol, 分析/色谱
- Heterocycles
- {SNA} Alphabetic, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, Cell Biology, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, I, Neat Compounds
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Aromatics
产品应用
- A non-steroidal anti-inflammatory agent
相关文献及参考
- Richardson, S., et al.: Anal. Chem., 75, 2831 (2003
安全信息
GHS Symbol
- P301+P310
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- H351 Suspected of causing cancer 怀疑致癌
- H301 Toxic if swallowed 吞食有毒
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S22 Do not breathe dust 不要吸入粉尘；
- R25 Toxic if swallowed 吞咽有毒
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,1100,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 84 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,1100,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 84 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 112,291,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 375 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - ataxia REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 36,1037,1981
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