Sodium 2-(5-(4-Chlorobenzoyl)-1,4-Dimethyl-1H-Pyrrol-2-Yl)Acetate 2-(5-(4-氯苯甲酰基)-1,4-二甲基-1H-吡咯-2-基)乙酸钠

CAS 64092-48-4 MFCD00057223

化学结构图

64092-48-4
SMILES: [Na+].CC1C=C(CC([O-])=O)N(C)C=1C(=O)C1C=CC(Cl)=CC=1

化学属性

Mol. FormulaC15H13ClNO3Na
Mol. Weight313.71

别名和识别编码

Chemical NameSodium 2-(5-(4-Chlorobenzoyl)-1,4-Dimethyl-1H-Pyrrol-2-Yl)Acetate
CAS Number64092-48-4
Synonym 5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetic Acid Sodium Salt 5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetic acid sodium salt 5-(p-Chlorobenzoyl)-1,4-dimethylpyrrole-2-acetic acid sodium-potassium salt McN 2783-21-98 Sodium Zomepirac Zomax Zomepirac Sodium Zomepirac Sodium Salt Zomepirac sodium salt
MDL NumberMFCD00057223
PubChem Substance ID24902176
EC Number264-669-2
Wiswesser Line NotationT5NJ A1 BVR DG& C1 E1VO &-NA- &QH 2
Chemical Name Translation2-(5-(4-氯苯甲酰基)-1,4-二甲基-1H-吡咯-2-基)乙酸钠
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分类

  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Drug Efflux Pumps, Drug Transport Compounds, Drug Transport Proteins & Reagents, Membrane Protein Biology Tools, Modulators for MRP Transporters, Mult
  • Heterocycles
  • {SNA} Bioactive Small Molecule Alphabetical Index, Drug Efflux Pumps, Drug Transport Compounds, Drug Transport Proteins & Reagents, Membrane Protein Biology Tools, Modulators for MRP Transporters, Multi-Drug Resistance, Multi-Drug Resistance and Drug Metabolism, Z, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学,

产品应用

  • Zomepirac is an analgesic, anti-inflammatory drug.

相关文献及参考

  • Sofia, R., et al.: Pharmacol. Res. Commun., 11, 179 (1979),
  • Grindel, J.M., et al.: Drug Metab. Dispos., 8, 343 (1980),
  • Steele, C.E., et al.: Curr. Med. Res. Opin., 8, 382 (1983),

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P301+P310
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
Signal word Danger
Hazard statements
  • H331 Toxic if inhaled 吸入中毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H300 Fatal if swallowed 吞食致命
RTECSUX9277000
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S22 Do not breathe dust 不要吸入粉尘；
Hazard Codes T
Risk Statements
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 27 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRUGAY Drugs. International Journal of Current Therapeutics and Applied
   Pharmacology Reviews.  (ADIS Press International Inc., Suite B-30, Oxford
   Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047)  V.1- 1971- 
   Volume(issue)/page/year: 23,250,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 70 mg/kg/10D-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Immunological Including Allergic - anaphylaxis
REFERENCE :
   AJMEAZ American Journal of Medi

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 16 mg/kg/2D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   AIMDAP Archives of Internal Medicine.  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-    1908-  Volume(issue)/page/year: 143,1171,1983

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 117 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Cardiac - pulse rate increase, without fall in BP
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   JATOD3 Journal of Analytical Toxicology.  (Preston Pub. Inc., POB 48312,
   Niles, IL 60648) V.1-    1977-  Volume(issue)/page/year: 7,223,1983

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. Z - Bioactive Small Molecules
  1. Functional Group 官能团索引
  2. carboxylic acid salt

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