Hydroflumethiazide 氢氟噻嗪
CAS 135-09-1 MFCD00057316
化学结构图
SMILES: NS(=O)(=O)c1cc2c(cc1C(F)(F)F)NCNS2(=O)=O
化学属性
| Mol. Formula | C8H8F3N3O4S2 |
|---|---|
| Mol. Weight | 331.31 |
别名和识别编码
| Chemical Name | Hydroflumethiazide |
|---|---|
| CAS Number | 135-09-1 |
| Synonym | 3,4-Dihydro-7-sulfamyl-6-trifluoromethyl-2H-1,2,4-benzothiadiazine 3,4-Dihydro-6-(trifluoromethyl)- Dihydroflumethiazide Bristab Bristurin 氢氟噻嗪 Di-ademil |
| MDL Number | MFCD00057316 |
| PubChem Substance ID | 3647 |
| EC Number | 205-173-8 |
| Chemical Name Translation | 氢氟噻嗪 |
| Wiswesser Line Notation | T66 BSWM EM DHJ HXFFF ISZW |
| Beilstein Registry Number | 0342692 |
| LabNetwork Molecule ID | LN00198008 |
| InChI | InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16) |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- Sulfur & Selenium Compounds
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, H, HU - HZ, 分析/色谱
- {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, H, HU - HZ
- Amines
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, H, HU - HZ
产品应用
- Antihypertensive; diuretic.
相关文献及参考
- Piala, J.J., et al.: J. Pharmacol. Exp. Ther., 134, 273 (1961),
- Orzech, C.E., et al.: Anal. Profiles Drug Subs., 7, 297 (1978),
安全信息
GHS Symbol
- P342+P311
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R42/43
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,629,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1182 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #80M
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6280 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 134,273,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
京ICP备2020036287号